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Anti Stress · 90 capsules

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GN Laboratories

Reduce the harmful effects of stress on your well-being, performance and health while supporting your recovery after intense physical training Can...
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Original price €34,90

Original price €34,90 - Original price €34,90

Original price €34,90

Current price €31,06

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Current price €31,06

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Save 11% Save %

Siberian ginseng is a plant whose root is used to make medicine. Siberian ginseng is often referred to as an adaptogen. This is a non-medical term used to describe substances that can strengthen the body and increase overall resilience to everyday stress. In addition to its use as an adaptogen, Siberian ginseng is used for cardiovascular conditions such as high blood pressure, low blood pressure, arteriosclerosis and rheumatic heart disease.

Siberian ginseng is also used for kidney diseases, Alzheimer's disease, attention deficit hyperactivity disorder (ADHD), chronic fatigue syndrome, diabetes, fibromyalgia, rheumatoid arthritis, influenza, colds, chronic bronchitis and tuberculosis. Siberian ginseng is also used to treat the side effects of chemotherapy for cancer. Some people use Siberian ginseng to improve athletic performance and the ability to work. In addition to this, Siberian ginseng is used by some people to treat sleep problems and the symptoms of a type 2 herpes simplex infection. Siberian ginseng is also used to strengthen the immune system, prevent colds and increase appetite. In industrial production, Siberian ginseng is added to skin care products. Siberian ginseng should not be confused with other types of ginseng. Siberian ginseng is not the same as American ginseng or Panax ginseng. You should be careful which product you choose. American ginseng and Panax ginseng can be much more expensive than Siberian ginseng. It is said that the Soviet Union wanted their athletes to benefit from the advantages that ginseng has to offer, but wanted a cheaper version. This is why Siberian ginseng became popular and why most studies on Siberian ginseng were conducted in Russia. The quality of Siberian ginseng products can vary greatly. Siberian ginseng is often not properly identified or contains "impurities" with other ingredients that do not contribute to the effect of the product but take up space. Before taking Siberian ginseng, you should contact your doctor if you are taking any medications, as Siberian ginseng interacts with many prescription medications.

How does Siberian ginseng work?

Siberian ginseng contains chemicals that affect the brain, immune system and certain hormones. It may also contain chemicals that have activity against some bacteria and viruses.

Potential health benefits of Siberian ginseng

Siberian ginseng may boost the function of the immune system

Siberian ginseng may improve the function of the immune system and help the body fight infection. In animal studies, supplementation with a root extract of Siberian ginseng increased the production of immunoglobulin G and M (IgG and IgM), which bind pathogens such as viruses and bacteria and mark them as targets for destruction. This process protects the body against infections and diseases (1). Siberian ginseng may also increase the levels of some types of white blood cells including T-cells and natural killer cells of the immune system (2).

Siberian ginseng appears to have antiviral properties

Practitioners often use Siberian ginseng to treat viral infections including the common cold and flu. In limited clinical trials, an extract of Siberian ginseng was found to reduce symptoms of the common cold when taken within 72 hours of the first onset of symptoms (3, 4). In one study, scientists infected human lung cells with flu viruses and then treated them with Siberian ginseng. These cells produced significantly fewer new viruses (5). Another study suggests that Siberian ginseng can kill RNA viruses such as cold and flu viruses, but not DNA viruses such as herpes viruses (6). However, in another study, 400 mg of Siberian ginseng extract per day for 6 months reduced the rate of herpes simplex infections. Subjects who took this extract also experienced a reduced frequency and severity of symptoms (7).

Siberian ginseng could be helpful for diabetes

An extract of Siberian ginseng may improve blood sugar levels, insulin sensitivity and fatty acid levels, all of which may help prevent diabetes. In one study, subjects who took 480 mg of Siberian ginseng extract per day showed reduced fasting blood glucose levels and reduced blood glucose levels after meals. The HbA1c value and the triglyceride and cholesterol levels were also lower (8). In diabetic mice, Siberian ginseng promoted the function of pancreatic cells that produce insulin and reduced both blood glucose levels and insulin resistance. Siberian ginseng also normalized blood glucose and insulin levels, as well as other diabetes markers, in diabetic rats (9, 10). In combination with carnithine, Siberian ginseng also prevented an increase in cholesterol levels and weight gain in rats fed a high-cholesterol diet (11).

Siberian ginseng can reduce fatigue

Many people who supplement with Siberian ginseng do so because of its energy-boosting effects. Siberian ginseng activates AMPK, which increases the metabolic rate and breaks down fat for energy production. Siberian ginseng can also activate BDNF, which increases the brain's ability to grow and adapt to new challenges (12, 13). Studies have also shown that supplements containing Siberian ginseng can improve stamina and mental focus and reduce fatigue (14, 15).

Siberian ginseng can increase athletic performance

In the short term, exercise suppresses the immune system and increases serotonin production in the midbrain. Increased serotonin levels in the midbrain reduce the frequency with which dopamine neurons fire, which makes training more demanding and can extend the required recovery time. In studies, Siberian ginseng has been shown to stimulate immune system function and reduce midbrain serotonin production during exercise. As a result, Siberian ginseng could accelerate recovery and improve the ability to regenerate (16, 17). In athletes, Siberian ginseng has been shown to improve several markers of performance. It increased the amount of time an athlete can sustain a given performance, reduced maximum heart rate - a measure of exercise intensity - reduced the amount of glucose in the blood, and increased the amount of free fatty acids in the blood during exercise. As a result, Siberian ginseng may have a glycogen-sparing effect, causing a shift from carbohydrates to fats for energy (18, 19). Supplementation with Siberian ginseng may also improve blood flow, which may contribute to faster recovery. In addition, Siberian ginseng protected muscles from damage during exercise (20, 21).

Siberian ginseng can reduce oxidative stress

Siberian ginseng acts as an antioxidant, which means that it neutralizes free radicals and thereby supports cellular health. Several compounds in Siberian ginseng bind and neutralize free radicals, preventing oxidative stress and cellular damage (35).

Siberian ginseng can alleviate physical and mental stress

In animal studies, Siberian ginseng has been shown to improve mental function and reduce recovery time after stressful events such as forced swimming, sleep deprivation or a new environment (22, 23) Siberian ginseng may activate BDNF, which helps the brain adapt to change. It also increases AMPK levels, which boosts energy and helps us keep going when we are stressed and tired. Finally, Siberian ginseng activates HSP70 and increases the body's resistance to tissue damage (24, 25, 26). In combination, these effects may explain the anti-stress effects of Siberian ginseng. These benefits are somewhat controversial. Some studies suggest that Siberian ginseng sometimes increases and sometimes decreases the stress response. This controversy could be explained by the hormetic effects of Siberian ginseng. Hormesis is an innate enhancement mechanism of the body - it is the phenomenon that a mild, temporary stressor causes a shift to higher performance. Adaptogens such as Siberian ginseng could act as mild hormetic stressors (27).

Siberian ginseng could improve memory performance

In a study of 30 elderly people treated for high blood pressure, Siberian ginseng improved brain function (28). In animals with Alzheimer's disease, high doses of Siberian ginseng improved memory and learning ability. Eleutheroside B and E increased acetolincholine levels in the hippocampus region of the brain, which improved communication between neurons (29). High levels of stress damage the brain's ability to learn, form new memories and draw on existing memories. The stress-reducing properties of Siberian ginseng may help to eliminate memory deficits when they are caused by stress (30). Finally, oxidative stress can impair both short-term and long-term memory. The antioxidant properties of Siberian ginseng may therefore help to improve memory performance (31).

Siberian ginseng could improve the function of the lymphatic system

Within four hours of taking Siberian ginseng, healthy women showed reduced swelling in their lower legs. Eleutheroside E appears to activate a receptor called Tie2, which stabilizes the lymphatic vessels and improves the function of the lymphatic system (32).

Siberian ginseng has anti-inflammatory properties

Cyclooxygenase 2 - or COX-2 - is an enzyme that exacerbates inflammation and pain. Widely used non-steroidal anti-inflammatory drugs work by blocking this enzyme. Siberian ginseng activates an enzyme called heme oxygenase 1, which blocks COX-2 and thereby reduces inflammation (33).

Siberian ginseng could alleviate allergy symptoms

Siberian ginseng could also reduce allergy symptoms. Mast cells - a type of white blood cell, are responsible for most allergic reactions and Siberian ginseng reduced the activity of these mast cells in rats (34).

Siberian ginseng could alleviate a hangover

A hangover after excessive alcohol consumption is very stressful for the body and causes symptoms such as exhaustion, dizziness and nausea. Siberian ginseng may help the body return to normal function and reduce symptoms of a hangover, according to a human study (36).

Siberian ginseng could counteract osteoporosis

In a study of Korean women, supplements containing Siberian ginseng increased levels of osteocalcin - a hormone that increases bone-building activity. However, this study did not observe a direct significant increase in bone mineral density (37). In a study conducted with rats, an extract of Siberian ginseng prevented a reduction in bone mineral density (38).

Siberian ginseng could alleviate Parkinson's symptoms

Parkinson's disease causes damage and degeneration in the basal ganglia region of the brain. This degeneration leads to the movement problems typical of Parkinson's. Siberian ginseng could help to prevent these symptoms. In animal studies, extracts and isolated compounds from Siberian ginseng, such as sesamin, have been shown to protect nerves and brain cells from damage and death. This protective effect is likely due to Siberian ginseng's ability to increase dopamine levels in the brain (39).

Siberian ginseng could protect against mosquito bites

The essential oil from the leaves of Siberian ginseng keeps mosquitoes away. The oil is about 75% as effective as pharmaceuticals at protecting against mosquito bites and an isolated compound from this oil called alpha-bisabolol is just as effective (40).

Siberian ginseng may have anti-cancer effects

Siberian ginseng appears to improve immune function in healthy people and cancer patients, and some scientists believe it may reduce the long-term risk of infection and help the body fight malignant tumors (41). When scientists exposed healthy bacteria to carcinogenic toxins, Siberian ginseng was able to halve their mutation rate. An extract of Siberian ginseng could also protect cells from mutations caused by radiation, although this effect is small (42). In addition, the effects of Siberian ginseng on human gastric cancer, lung cancer and esophageal cancer cells have been investigated. In addition, Siberian ginseng has been shown to block estrogen receptors in cell studies, which may help treat estrogen-related cancer (43).

Siberian ginseng could be helpful for bipolar disorder

In a promising clinical trial of 76 teenagers with bipolar disorder, 1.5 grams of Siberian ginseng and lithium produced improvements comparable to 20 mg of fluoxetine and lithium, a standard treatment (44). Both response rate and remission rate were equivalent for both treatments, with the group receiving Siberian ginseng reporting fewer side effects.

Siberian ginseng could help with cadmium poisoning

Cadmium is a toxic metal that suppresses the immune system. When the body is exposed to cadmium, cadmium accumulates in the spleen and reduces the number of white blood cells in this organ. The more cadmium accumulates, the fewer white blood cells are found in the spleen and the weaker the immune system becomes. In mice, Siberian ginseng was able to reverse the effects of cadmium poisoning and remove cadmium from the spleen (45).

Safety and side effects

Siberian ginseng is probably safe and harmless for most adults for short-term use. Although side effects are rare, some people may experience drowsiness, changes in heart rate, sadness, anxiety, muscle cramps and other side effects. High doses may cause an increase in blood pressure.

Precautions and warnings:

Pregnancy and lactation: not enough is known about the use of Siberian ginseng during pregnancy and lactation. For this reason, pregnant and breastfeeding women should avoid Siberian ginseng.

Heart disease: Siberian ginseng can cause palpitations, irregular heartbeat and high blood pressure. People who suffer from cardiovascular diseases such as arteriosclerosis and rheumatic heart disease, or who have suffered a heart attack in the past, should only use Siberian ginseng under medical supervision.

High blood pressure: Siberian ginseng should not be used by people whose blood pressure is above 180/90. Siberian ginseng could aggravate an existing high blood pressure. Hormone-sensitive diseases such as breast cancer, uterine cancer, ovarian cancer and endometriosis: Siberian ginseng may act like estrogen. If you suffer from a disease that could be aggravated by estrogen, you should not use Siberian ginseng. Diabetes: Siberian ginseng can affect blood sugar levels. If you have diabetes and use Siberian ginseng, you should carefully monitor your blood pressure. Mental illnesses such as mania and schizophrenia: Siberian ginseng may aggravate these conditions and should be used with caution.

Interactions

Care should be taken when combining Siberian ginseng with the following medications:

Alcohol

Alcohol can cause drowsiness and dizziness. Siberian ginseng may also cause drowsiness and dizziness. Taking large amounts of Siberian ginseng in combination with alcohol could cause excessive drowsiness

Digoxin

Digoxin helps the heart to beat more strongly. One person had too much digoxin in their body while taking a natural product that may have contained Siberian ginseng. However, it is unclear whether Siberian ginseng or other plant components in this supplement were the cause.

Lithium

Siberian ginseng may have a dehydrating (diuretic) effect. Taking Siberian ginseng may interfere with the body's excretion of lithium, which could result in increased lithium levels and serious side effects. For this reason, it is important to consult your doctor before using Siberian ginseng if you are taking lithium. The lithium dosage may need to be adjusted.

Drugs that are broken down by the liver (cytochrome P450 1A2 (CYP1A2) substrates, cytochrome P450 2C9 (CYP2C9 substrates)

Some drugs are broken down by the liver. Siberian ginseng can reduce the rate at which the liver breaks down certain drugs. Taking Siberian ginseng in conjunction with medications that are broken down by the liver may increase the side effects of some medications. For this reason, you should consult your doctor before taking Siberian ginseng if you are taking medication that is broken down by the liver.

Diabetes medication

Siberian ginseng could affect blood sugar and either lower or raise it. Diabetes medications are used to lower blood sugar levels. Taking Siberian ginseng in combination with diabetes medication could result in an excessive drop in blood sugar levels or reduce the effectiveness of diabetes medication. For this reason, blood glucose levels should be carefully monitored. It is possible that the dosage of diabetes medication may need to be adjusted.

Drugs that slow down blood clotting

Siberian ginseng could slow down blood clotting. Taking Siberian ginseng in conjunction with medications that also slow blood clotting could increase the risk of bleeding and the tendency to bruise. Some medications that can slow blood clotting include aspirin, diclofenac (Voltaren), ibuprofen, naproxen, heparin, warfarin and others.

Sedatives (agents that suppress the CNS)

Siberian ginseng may cause drowsiness and dizziness. Drugs that cause drowsiness are called sedatives. Taking Siberian ginseng in combination with sedatives could increase drowsiness too much. Care should be taken when combining Siberian ginseng with the following medications:

Drugs that are broken down by the liver (cytochrome P450 2D6 (CYP2D6) substrates, cytochrome P450 3A4 (CYP3A4 substrates).

Dosage

The following dosages have been investigated in scientific studies: Oral:

For herpes simplex type 2 infections: An extract of Siberian ginseng standardized to 0.3% eleutherosides at a dosage of 400 mg per day.
For colds: 400 mg of a combination of Siberian ginseng and a specific andrographis extract standardized to 4 to 5.6 mg andrographolide (Kan Jang, Swedish Herbal Institute) three times daily.

References

Further sources

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Siberian ginseng

Anti Stress · 90 capsules