Linseed oil
Linseed is the seed of the plant Linum Usitatissimum. The oil from these seeds is used to make medicine. Linseed oil is used for many different conditions including rheumatoid arthritis and high cholesterol levels. Other uses include trying to treat osteoarthritis, anxiety, benign prostate enlargement, vaginal infections, dry eyes, arteriosclerosis, high blood pressure, heart disease, diabetes and attention deficit hyperactivity disorder (ADHD). Some people use linseed oil as a laxative for constipation, to aid weight loss and to prevent breast cancer and prostate cancer. Linseed oil is also applied to the skin to soothe skin irritations or soften rough skin. In food, linseed oil is used in margarine and as an oil for cooking. In industrial production, linseed oil is used as an ingredient in paints, varnishes, linoleum and soap, as well as a waterproofing ingredient. Linseed oil easily breaks down into its chemical components when exposed to light, heat or air. For this reason, linseed oil should be stored in an opaque or dark bottle protected from heat. Linseed oil can also be stored in the refrigerator.
How does linseed oil work?
Linseed oil is a source of polyunsaturated fatty acids such as alpha-linolenic acid. The alpha-linolenic acid and related chemicals found in linseed oil appear to reduce inflammation. For this reason, it is believed that linseed oil may be beneficial for rheumatoid arthritis and other inflammatory conditions.
How effective is linseed oil?
Linseed oil may not be effective for the following conditions:
- High blood lipid levels. Some research shows that taking linseed oil does not significantly lower cholesterol and triglyceride levels in people with high cholesterol and triglyceride levels.
- Rheumatoid arthritis. Daily intake of linseed oil over a 3-month period does not appear to improve symptoms such as pain and stiffness, nor does it have any effect on laboratory tests that measure the severity of rheumatoid arthritis.
There is insufficient scientific data to draw any conclusions about the effectiveness of linseed oil for the following conditions and applications:
- Attention Deficit Hyperactivity Disorder (ADHD). There is some evidence that taking linseed oil may improve attention, impulsivity, restlessness and self-control in children suffering from ADHD.
- Arteriosclerosis. There is evidence that increasing the amount of linolenic acid in the diet may help prevent hardening of the arteries. Linseed oil contains alpha-linolenic acid, which is why some people assume that linseed oil should protect against arteriosclerosis. Even if this assumption is plausible, there have not yet been any scientific studies that have proven the correctness of this assumption.
- Breast cancer. Scientific studies have shown that women who have higher levels of alpha-linolenic acid in their breast tissue are less likely to develop breast cancer. Scientists think that a high intake of linolenic acid in the diet could protect against breast cancer. Linseed oil is a source of linolenic acid, but it is not known whether increased consumption of linseed oil actually helps prevent breast cancer.
- Heart disease. There is evidence that people with existing heart disease who get more alpha-linolenic acid in their diet have a lower risk of dying from heart disease. Linseed oil is a source of alpha-linolenic acid, but no scientific studies have yet directly investigated the effects of linseed oil consumption on heart disease. It is also not known whether linseed oil supplements have the same effect as linseed oil from food.
- Diabetes. Scientific research suggests that flaxseed oil does not lower blood sugar in people suffering from type 2 diabetes.
- Dry eyes. Some preliminary research suggests that taking linseed oil may reduce irritation and symptoms of dry eyes. A specific product containing fish oil and linseed oil may reduce dry eye symptoms and increase tear production.
- High blood pressure: Early study results suggest that linseed oil supplements may help lower blood pressure in men with normal blood pressure but high cholesterol levels. However, further research is needed to see if linseed oil can also lower blood pressure in people who suffer from high blood pressure.
- Prostate cancer. The results of studies on the role of the linseed oil ingredient alpha-linolenic acid in prostate cancer are contradictory. Some epidemiological studies suggest that a high dietary intake of alpha-linolenic acid is associated with an increased risk of prostate cancer. Other studies suggest that a high intake of alpha-linolenic acid or high alpha-linolenic acid blood levels are not associated with an increased risk of prostate cancer, although additional alpha-linolenic acid may exacerbate existing prostate cancer. The source of alpha-linolenic acid appears to be important in this context. Alpha-linolenic acid from dairy products and meat has been positively associated with prostate cancer, whereas alpha-linolenic acid from plant sources such as flaxseed or linseed oil does not affect prostate cancer risk.
There is also insufficient scientific data on the effectiveness of linseed oil for anxiety, constipation, cancer and vaginal problems, as well as its use to support weight loss.
Further scientific research is needed to evaluate the effectiveness of linseed oil in these applications.
Safety and side effects
Linseed oil is probably safe and harmless for most adults when used in reasonable amounts over a short period of time. High doses of 30 grams per day and above may cause loose stools and diarrhea. Allergic reactions have also occurred in some people while using linseed oil. Some men worry that taking linseed oil could increase their risk of prostate cancer due to the alpha-linolenic acid contained in linseed oil. Science is still deciphering the role that alpha-linolenic acid plays in prostate cancer. Some studies suggest that alpha-linolenic acid may exacerbate existing prostate cancer, but other studies have failed to find such a link. Regardless, the alpha-linolenic acid found in linseed oil does not appear to be a problem. Alpha-linolenic acid from plant sources such as linseed oil does not appear to affect prostate cancer risk, although alpha-linolenic acid from dairy products and meat has been linked to prostate cancer in some studies. Not enough is known about the safety of linseed oil applied to the skin.
Precautions and warnings
Pregnancy: Linseed oil may not be safe to use during pregnancy. Some research suggests that linseed oil may increase the risk of premature birth if taken during the second or third trimester of pregnancy. For this reason, pregnant women should avoid linseed oil.
Breastfeeding: There is not enough reliable information on the safety and safety of linseed oil during breastfeeding, so breastfeeding women should err on the side of caution and avoid linseed oil until more is known.
Bleeding disorders: Linseed oil could increase the risk of severe bleeding in patients with bleeding disorders. For this reason, you should consult your doctor before using linseed oil if you suffer from a bleeding disorder.
Surgeries: Linseed oil appears to increase the risk of bleeding during and after surgery. For this reason, you should stop using linseed oil two weeks before an operation.
Interactions
Care should be taken when combining linseed oil with the following medications:
Medications that slow down blood clotting Linseed oil could slow down blood clotting. Taking linseed oil in combination with medications that also slow down blood clotting could increase the risk of bleeding and the tendency to bruise. Some medications that can slow blood clotting include aspirin, diclofenac (Voltaren), ibuprofen, naproxen and others.
Dosage
An appropriate dosage of linseed oil depends on various factors such as age, state of health and others. At the present time, there is insufficient scientific data to be able to make a statement about appropriate dosage ranges for linseed oil. For this reason, you should follow the dosage instructions on the label and/or consult a doctor or pharmacist before use.
References
- Allman MA, Pena MM, Pang D. Supplementation with flaxseed oil versus sunflower seed oil in healthy young men consuming a low fat diet: effects on platelet composition and function. Eur J Clin Nutr 1995;49:169-78.
- Alonso L, Marcos ML, Blanco JG, et al. Anaphylaxis caused by linseed (flaxseed) intake. J Allergy Clin Immunol 1996;98:469-70.
- Ascherio A, Rimm EB, Giovannucci EL, et al. Dietary fat and risk of coronary heart disease in men: cohort follow up study in the United States. BMJ 1996;313:84-90.
- Barceló-Coblijn G, Murphy EJ, Othman R, et al. Flaxseed oil and fish-oil capsule consumption alters human red blood cell n-3 fatty acid composition: a multiple-dosing trial comparing 2 sources of n-3 fatty acid. Am J Clin Nutr 2008;88:801-9.
- Barre DE, Mizier-Barre KA, Griscti O, Hafez K. High dose flaxseed oil supplementation may affect fasting blood serum glucose management in human type 2 diabetics. J Oleo Sci 2008;57:269-73.
- Bloedon LT, Szapary PO. Flaxseed and cardiovascular risk. Nutr Rev 2004;62:18-27.
- Brouwer IA, Katan MB, Zock PL. Dietary alpha-linolenic acid is associated with reduced risk of fatal coronary heart disease, but increased prostate cancer risk: a meta-analysis. J Nutr 2004;134:919-22.
- Chavarro JE, Stampfer MJ, Li H, et al. A prospective study of polyunsaturated fatty acid levels in blood and prostate cancer risk. Cancer Epidemiol Biomarkers Prev 2007;16:1364-70.
- Christensen JH, Christensen MS, Toft E, et al. Alpha-linolenic acid and heart rate variability. Nutr Metab Cardiovasc Dis 2000;10:57-61.
- Crawford M, Galli C, Visioli F, et al. Role of Plant-Derived Omega-3 Fatty Acids in Human Nutrition. Ann Nutr Metab 2000;44:263-5.
- Cunnane SC, Ganguli S, Menard C, et al. High alpha-linolenic acid flaxseed (Linum usitatissimum): some nutritional properties in humans. Br J Nutr 1993;69:443-53.
- Cunnane SC, Hamadeh MJ, Liede AC, et al. Nutritional attributes of traditional flaxseed in healthy young adults. Am J Clin Nutr 1995;61:62-8.
- de Deckere EAM, Korver O, Verschuren PM, Katan MB. Health aspects of fish and n-3 polyunsaturated fatty acids from plant and marine origin. Eur J Clin Nutr 1998;52:749-53.
- de Lorgeril M, Renaud S, Mamelle N, et al. Mediterranean alpha-linolenic acid-rich diet in secondary prevention of coronary heart disease. Lancet 1994;343:1454-9.
- De Stefani E, Deneo-Pellegrini H, Boffetta P, et al. Alpha-linolenic acid and risk of prostate cancer: a case-control study in Uruguay. Cancer Epidemiol Biomarkers Prev 2000;9:335-8.
- Din JN, Newby DE, Flapan AD. Omega 3 fatty acids and cardiovascular disease--fishing for a natural treatment. BMJ 2004;328:30-5.
- Djousse L, Arnett DK, Carr JJ, et al. Dietary linolenic acid is inversely associated with calcified atherosclerotic plaque in the coronary arteries: the National Heart, Lung, and Blood Institute Family Heart Study. Circulation 2005;111:2921-6.
- Djousse L, Arnett DK, Pankow JS, et al. Dietary linolenic acid is associated with a lower prevalence of hypertension in the NHLBI Family Heart Study. Hypertension 2005;45:368-73.
- Djousse L, Rautaharju PM, Hopkins PN, et al. Dietary linolenic acid and adjusted QT and JT intervals in the National Heart, Lung, and Blood Institute Family Heart study. J Am Coll Cardiol 2005;45:1716-22.
- Finnegan YE, Howarth D, Minihane AM, et al. Plant and marine derived (n-3) polyunsaturated fatty acids do not affect blood coagulation and fibrinolytic factors in moderately hyperlipidemic humans. J Nutr 2003;133:2210-3.
- Finnegan YE, Minihane AM, Leigh-Firbank EC, et al. Plant- and marine-derived n-3 polyunsaturated fatty acids have differential effects on fasting and postprandial blood lipid concentrations and on the susceptibility of LDL to oxidative modification in moderately hyperlipidemic subjects. Am J Clin Nutr 2003;77:783-95.
- Fischer S, Honigmann G, Hora C, et al [Results of linseed oil and olive oil therapy in hyperlipoproteinemia patients]. Dtsch Z Verdau Stoffwechselkr 1984;44:245-51.
- Francois CA, Connor SL, Bolewicz LC, Connor WE. Supplementing lactating women with flaxseed oil does not increase docosahexaenoic acid in their milk. Am J Clin Nutr 2003;77:226-33.
- Freese R, Mutanen M. Alpha-linolenic acid and marine long-chain n-3 fatty acids differ only slightly in their effects on hemostatic factors in healthy subjects. Am J Clin Nutr 1997;66:591-8.
- Giovannucci E, Rimm EB, Colditz GA, et al. A prospective study of dietary fat and risk of prostate cancer. J Natl Cancer Inst 1993;85:1571-9.
- Harper CR, Edwards MC, Jacobson TA. Flaxseed oil supplementation does not affect plasma lipoprotein concentration or particle size in human subjects. J Nutr 2006;136:2844-8.
- Hooper L, Thompson RL, Harrison RA, et al. Omega 3 fatty acids for prevention and treatment of cardiovascular disease. Cochrane Database Syst Rev 2004;(4):CD003177.
- Hu FB, Stampfer MJ, Manson JE, et al. Dietary intake of alpha-linolenic acid and risk of fatal ischemic heart disease among women. Am J Clin Nutr 1999;69:890-7.
- Iso H, Sato S, Umemura U, et al. Linoleic acid, other fatty acids, and the risk of stroke. Stroke 2002;33:2086-93.
- Joshi K, Lad S, Kale M, et al. Supplementation with flax oil and vitamin C improves the outcome of Attention Deficit Hyperactivity Disorder (ADHD). Prostaglandins Leukot Essent Fatty Acids 2006;74:17-21.
- Kaul N, Kreml R, Austria JA, et al. A comparison of fish oil, flaxseed oil and hempseed oil supplementation on selected parameters of cardiovascular health in healthy volunteers. J Am Coll Nutr 2008;27:51-8.
- Klein V, Chajes V, Germain E, et al. Low alpha-linolenic acid content of adipose breast tissue is associated with an increased risk of breast cancer. Eur J Cancer 2000;36:335-40.
- Kolonel LN, Nomura AM, Cooney RV. Dietary fat and prostate cancer: current status. J Natl Cancer Inst 1999;91:414-28.
- Kris-Ehterton PM, Harris WS, Appel LJ, et al. Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Circulation 2002;106:2747-57.
- Laaksonen DE, Laukkanen JA, Niskanen L, et al. Serum linoleic and total polyunsaturated fatty acids in relation to prostate and other cancers: a population-based cohort study. Int J Cancer 2004;111:444-50.
- Leitzmann MF, Stampfer MJ, Michaud DS, et al. Dietary intake of n-3 and n-6 fatty acids and the risk of prostate cancer. Am J Clin Nutr 2004;80:204-16.
- Mann J, Truswell AS, eds. Essentials of Human Nutrition. Oxford: Oxford Univ Press 1998.
- Merchant AT, Curhan GC, Rimm EB, et al. Intake of n-6 and n-3 fatty acids and fish and risk of community-acquired pnemonia in US men. Am J Clin Nutr 2005;82:668-74.
- Mozaffarian D, Ascherio A, Hu FB, et al. Interplay between different polyunsaturated fatty acids and risk of coronary heart disease in men. Circulation 2005;111:157-64.
- Nestel PJ, Pomeroy SE, Sasahara T, et al. Arterial compliance in obese subjects is improved with dietary plant n-3 fatty acid from flaxseed oil despite increased LDL oxidizability. Arterioscler Thromb Vasc Biol 1997;17:1163-70.
- Nordstrom DC, Honkanen VE, Nasu Y, et al. Alpha-linolenic acid in the treatment of rheumatoid arthritis. A double-blind, placebo-controlled and randomized study: flaxseed vs. safflower seed. Rheumatol Int 1995;14:231-4.
- Pang D, Allman-Farinelli MA, Wong T, et al. Replacement of linoleic acid with alpha-linolenic acid does not alter blood lipids in normolipidaemic men. Br J Nutr 1998;80:163-7.
- Paschos GK, Magkos F, Panagiotakos DB, et al. Dietary supplementation with flaxseed oil lowers blood pressure in dyslipidaemic patients. Eur J Clin Nutr 2007;61:1201-6.
- Pinheiro MN Jr, dos Santos PM, dos Santos RC, et al [Oral flaxseed oil (Linum usitatissimum) in the treatment for dry-eye Sjögren's syndrome patients]. Arq Bras Oftalmol 2007;70:649-55.
- Prasad K. Dietary flax seed in prevention of hypercholesterolemic atherosclerosis. Atherosclerosis 1997;132:69-76.
- Ramon JM, Bou R, Romea S, et al. Dietary fat intake and prostate cancer risk: a case-control study in Spain. Cancer Causes Control 2000;11:679-85.
- Thompson LU, Rickard SE, Orcheson LJ, Seidl MM. Flaxseed and its lignan and oil components reduce mammary tumor growth at a late stage of carcinogenesis. Carcinogenesis 1996;17:1373-6.
- University of Montreal. Pregnant Women Consuming Flaxseed Oil Have High Risk Of Premature Birth.ScienceDaily, October 29, 2008. Available at: www.sciencedaily.com/releases/2008/10/081027140817.htm (Accessed May 14, 2009).
- Wojtowicz JC, Butovich I, Uchiyama E, et al. Pilot, prospective, randomized, double-masked, placebo-controlled clinical trial of an omega-3 supplement for dry eye. Cornea 2010 Oct 28 [Epub ahead of print].