Vitamin E succinates and prostate cancer

Vitamin E is an important antioxidant that fights destructive free radicals that promote aging and a breakdown of the immune system. Many people take vitamin E supplements to prevent heart disease, prostate and breast cancer and to boost the immune system. Science has not always been consistent in supporting the health benefits of vitamin E. One problem is that scientists have not always controlled the form of vitamin E, which could provide insight into its effectiveness. Vitamin E belongs to a group of naturally occurring chemicals, including alpha-, beta-, gamma- and delta-tocopherols and vitamin E derivatives, including vitamin E acetate, succinates and nicotinates. Alpha-tocopherol is the form of vitamin E that has been used in most studies and is found in most supplements. Some studies suggest that supplements containing gamma and alpha tocopherols reduce the risk of prostate and colon cancer, while gamma plus delta tocopherols reduce the risk of breast cancer. Scientists at Texas Women's University reviewed the existing literature and suggested that vitamin E succinate is probably the most effective for prostate cancer prevention. It works by breaking down cancer cell membranes and is particularly effective when given in conjunction with anti-cancer drugs and anti-androgens. (Nutrition Rev, 63:247-255, 2005)