GN Laboratories

N-Acetyl L-Cysteine - 120 capsules

120 capsules
  • ✓ 500 mg N-Acetyl-L-Cystein pro Kapsel
  • ✓ 120 Kapseln pro Dose
  • ✓ Stabilisierte, bioverfügbare Aminosäure-Form
€22,90
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NAC capsules with 500 mg N-acetyl-L-cysteine per capsule: the stabilized form of the sulphur-containing amino acid that your body can actually absorb. The pure variant oxidizes quickly and loses a large part of its bioavailability. GN Laboratories provides you with the acetylated variant in a vegan capsule, without any detours.

The most important facts at a glance:

  • 500 mg N-acetyl-L-cysteine per capsule, highly dosed
  • 120 capsules per can, supply for up to 4 months
  • Stabilized, bioavailable amino acid form
  • Vegan capsule shell (HPMC), without unnecessary additives
  • Manufactured in Germany
  • Laboratory-tested for purity and content
Compositionper capsule
N-acetyl-L-cysteine500 mg
Zutaten:
N-acetyl-L-cysteine, bulking agent: microcrystalline cellulose, capsule shell: hydroxypropylmethylcellulose.
Take 1 to 2 capsules daily with sufficient water between meals.

**Manufacturer / Distributor** GN Laboratories Europe, London / United Kingdom | Nero Labs BV, Postbus 278, 5900AG Venlo, The Netherlands | Food supplement with N-acetyl-L-cysteine. Do not exceed the recommended daily intake. Food supplements are not a substitute for a balanced, varied diet and a healthy lifestyle. Keep out of the reach of small children.

¹ *Zhang et al. (2018): N-acetylcysteine alleviates H2O2-induced damage via regulating the redox status of intracellular antioxidants in H9c2 cells. PMC.* [https://pmc.ncbi.nlm.nih.gov/articles/PMC6257848/](https://pmc.ncbi.nlm.nih.gov/articles/PMC6257848/), (0) Chad Kerksick, Darryn WilloughbyThe antioxidant role of glutathione and N-acetyl-cysteine supplements and exercise-induced oxidative stressJ Int Soc Sports Nutr.(2005 Dec 9)

(2) Gerry K SchwalfenbergN-Acetylcysteine: A Review of Clinical Usefulness (an Old Drug with New Tricks)J Nutr Metab.(2021 Jun 9)

(3) Calzetta L, Matera MG, Rogliani P, Cazzola M. Multifaceted activity of N-acetyl-l-cysteine in chronic obstructive pulmonary disease. Expert Rev Respir Med. 2018 Aug;12(8):693-708. doi: 10.1080/17476348.2018.1495562. Epub 2018 Jul 17. PMID: 29972340.

(4) Liu H, Wang W, Gao X. Comparison of the efficacy of ambroxol hydrochloride and N -acetylcysteine in the treatment of children with bronchopneumonia and their influence on prognosis. Exp Ther Med. 2020 Dec;20(6):130. doi: 10.3892/etm.2020.9260. Epub 2020 Oct 1. PMID: 33082862; PMCID: PMC7557708.

(5) Ahmad KA, Yuan Yuan D, Nawaz W, Ze H, Zhuo CX, Talal B, Taleb A, Mais E, Qilong D. Antioxidant therapy for management of oxidative stress induced hypertension. Free Radic Res. 2017 Apr;51(4):428-438. doi: 10.1080/10715762.2017.1322205. Epub 2017 May 9. PMID: 28427291.

(6) Liguori I, Russo G, Curcio F, Bulli G, Aran L, Della-Morte D, Gargiulo G, Testa G, Cacciatore F, Bonaduce D, Abete P. Oxidative stress, aging, and diseases. Clin Interv Aging. 2018 Apr 26;13:757-772. doi: 10.2147/CIA.S158513. PMID: 29731617; PMCID: PMC5927356.

(7) Mason SA, Trewin AJ, Parker L, Wadley GD. Antioxidant supplements and endurance exercise: Current evidence and mechanistic insights. Redox Biol. 2020 Aug;35:101471. doi: 10.1016/j.redox.2020.101471. Epub 2020 Feb 20. PMID: 32127289; PMCID: PMC7284926.

(8) Andrews NP, Prasad A, Quyyumi AA. N-acetylcysteine improves coronary and peripheral vascular function. J Am Coll Cardiol. 2001 Jan;37(1):117-23. doi: 10.1016/s0735-1097(00)01093-7. PMID: 11153725.

(9) Najafi A, Mojtahedzadeh M, Ahmadi KH, Abdollahi M, Mousavi M, Chelkeba L, Najmeddin F, Ahmadi A. The immunological benefit of higher dose N-acetyl cysteine following mechanical ventilation in critically ill patients. Daru. 2014 Jul 15;22(1):57. doi: 10.1186/2008-2231-22-57. PMID: 25027749; PMCID: PMC4223415.

(10)Kasperczyk S, Dobrakowski M, Kasperczyk A, Ostałowska A, Birkner E. The administration of N-acetylcysteine reduces oxidative stress and regulates glutathione metabolism in the blood cells of workers exposed to lead. Clin Toxicol (Phila). 2013 Jul;51(6):480-6. doi: 10.3109/15563650.2013.802797. Epub 2013 Jun 4. PMID: 23731375.

(11)Zhang H, Spapen H, Nguyen DN, Rogiers P, Bakker J, Vincent JL. Effects of N-acetyl-L-cysteine on regional blood flow during endotoxic shock. Eur Surg Res. 1995;27(5):292-300. doi: 10.1159/000129412. PMID: 7589000.

(12)Tenório MCDS, Graciliano NG, Moura FA, Oliveira ACM, Goulart MOF. N-Acetylcysteine (NAC): Impacts on Human Health. Antioxidants (Basel). 2021 Jun 16;10(6):967. doi: 10.3390/antiox10060967. PMID: 34208683; PMCID: PMC8234027.

(13)Rank N, Michel C, Haertel C, Lenhart A, Welte M, Meier-Hellmann A, Spies C. N-acetylcysteine increases liver blood flow and improves liver function in septic shock patients: results of a prospective, randomized, double-blind study. Crit Care Med. 2000 Dec;28(12):3799-807. doi: 10.1097/00003246-200012000-00006. PMID: 11153617.

Artikelnr.: 7892

What is NAC (N-acetyl-L-cysteine) and why is it supplemented?

You've heard of NAC, but what's really behind it? N-acetyl-cysteine is the stabilized form of L-cysteine. Stabilized means that an acetyl group protects the amino acid from oxidizing in the stomach. Without this protection, a large proportion is lost before your body can use it.

Once ingested, the ingredient is converted to L-cysteine. L-cysteine, in turn, is one of the three building blocks for glutathione, the most abundant tripeptide in your cells. This is why the acetylated form has become the preferred variant in supplementation.

N-acetyl cysteine or L-cysteine - what's the difference?

Both provide L-cysteine in the end. However, the way they get there differs significantly.

PropertyNACL-cysteine
StabilityHigh (acetylated, oxidation-resistant)Low (reacts quickly with oxygen)
BioavailabilityHighLimited
Supplement formStandard in capsules and tabletsRarely as a single supplement
Glutathione precursorYes (via L-cysteine)Yes (directly)

The pure form forms disulphide bridges on contact with oxygen. This sounds like a chemistry textbook, but it simply means that part of the ingredient is lost before it reaches the intestine.

The acetylated variant avoids this problem. The protective group keeps the molecule stable until it is absorbed. Only then is it converted and is available for glutathione synthesis.

Who is NAC suitable for as a supplement?

You train 4-5 times a week and notice that recovery takes longer than before. Intensive training uses up sulphur-containing amino acids faster than most nutrition plans provide. L-cysteine is one of the three building blocks for glutathione, and it is this pool that depletes first during high-intensity exercise. These high-dose capsules provide 500 mg of the stabilized precursor per capsule. Two on training days, one on rest days. You control it yourself.

You build up a stack and don't want to leave the glutathione base to chance. In biohacker circles, the GlyNAC stack (N-acetyl cysteine + glycine) is one of the most recommended combinations. Long-term users value the compound as an integral part of their daily routine. With 120 capsules per can, you have four months' supply without having to reorder.

The first thing you do with every supplement is read the list of ingredients. Then you won't have to search for long: N-acetyl-L-cysteine, capsule shell made from HPMC. That's it. No magnesium stearate, no fillers, no small print. Vegan, laboratory-tested, made in Germany.

How are the capsules taken?

One capsule contains 500 mg N-acetyl-L-cysteine. The recommended daily intake is 1 to 2 capsules.

Many products on the market only provide 250 or 300 mg per capsule. With 500 mg of high-dose N-acetyl cysteine per capsule, you need fewer capsules per day and retain full control over your dosage. One capsule or two, you decide. Depending on what the rest of your stack looks like.

Best taken between meals with plenty of water. The capsule size is compact. No gagging, no dissolving necessary.

Quality and production

GN Laboratories produces in Germany. Specifically, this means: production according to German food standards, independent laboratory tests for purity and content, documented batch traceability.

The capsule shell consists of hydroxypropyl methylcellulose (HPMC), is completely vegan and free from gelatine. When it comes to the ingredients, what's on the label is what's inside. No fillers, no hidden additives.

Each can contains 120 capsules, individually sealed to maintain product quality. One capsule a day lasts four months. With two capsules you have a two-month supply, at a unit price of less than 20 cents. Short delivery time within Germany, reviews can be found further down the page.

FAQ

Häufig gestellte Fragen

What is NAC used for?
N-acetyl cysteine is used to supply the body with the stabilized form of L-cysteine. The amino acid is a precursor of glutathione and is a sulphur-containing compound. In sports nutrition, the compound is an integral part of many supplement stacks.
How much NAC can I take per day?
The usual recommended daily intake is 500 to 1,000 mg. One capsule provides 500 mg, so you can take 1 or 2 capsules per day as required.
What is the difference between NAC and L-cysteine?
The acetylated form is the stabilized variant. The pure form oxidizes quickly and loses its bioavailability. For this reason, the N-acetyl form is used almost exclusively in supplementation.
Are the capsules vegan?
Yes, the capsule shell consists of HPMC (vegetable). The product contains no animal ingredients and no unnecessary additives.
What should I look out for when buying NAC?
Firstly, the dosage per capsule: 500 mg offers more flexibility than higher-dose products. Secondly, the purity: laboratory-tested and without fillers. Thirdly, the production: Made in Germany with documented quality assurance.
Can NAC be combined with other supplements?
Yes, in practice the amino acid is often taken together with vitamin C, zinc or glycine. Many stack users also combine it with glutathione or alpha-lipoic acid.

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