Gamma-oryzanol
Gamma oryzanol is a substance that is extracted from rice bran oil. It is also found in wheat bran and some types of fruit and vegetables. Gamma Oryzanol is used by some people as a medicine. Gamma Oryzanol is used for high cholesterol levels, as well as symptoms of menopause and aging. Some people use Gamma Oryzanol to increase testosterone levels and growth hormone levels, as well as to improve strength during resistance training.
How does Gamma Oryzanol work?
GammaOryzanol may lower cholesterol levels by reducing the absorption of cholesterol from food.
GammaOryzanol is also often promoted for the treatment of menopause, but it is unclear whether it works in this type of application. Some scientists suggest that gamma oryzanol may be helpful due to its effects on luteinizing hormone (LH). However, this effect has not yet been proven in humans. Some people use gamma oryzanol to increase testosterone and growth hormone levels. However, gamma oryzanol does not appear to have any effect on the levels of these hormones. In fact, animal studies suggest that gamma oryzanol may reduce testosterone production.
How effective is Gamma Oryzanol?
GammaOryzanol may be effective when used to reduce cholesterol levels. Gamma Oryzanol appears to significantly reduce total cholesterol levels, bad LDL cholesterol levels and triglyceride levels. The effects of gamma oryzanol on levels of good HDL cholesterol are less clear. Different studies have produced different results.
There is insufficient scientific data to draw a conclusion about the effectiveness of gamma oryzanol when used to increase testosterone and growth hormone levels, to improve strength during resistance training, and to treat symptoms of menopause and aging. Further scientific research is needed to evaluate the effectiveness of Gamma Oryzanol in these applications.
Safety and side effects
Gamma Oryzanol is potentially safe and harmless for most adults. However, the potential side effects of Gamma Oryzanol are not known.
Precautions and warnings
Pregnancy and lactation: Not enough is known about the use of Gamma Oryzanol during pregnancy and lactation. For this reason, pregnant and breastfeeding women should avoid benzoin.
Interactions
At the present time there is no information on interactions of Gamma Oryzanol with medications or supplements.
Dosage
The following dosages have been investigated in scientific studies:
Oral:
- To lower cholesterol levels: The usual dose of Gamma Oryzanol is 300 mg per day. One study used 100 mg three times a day.
References
- Accinni, R., Rosina, M., Bamonti, F., Della, Noce C., Tonini, A., Bernacchi, F., Campolo, J., Caruso, R., Novembrino, C., Ghersi, L., Lonati, S., Grossi, S., Ippolito, S., Lorenzano, E., Ciani, A., and Gorini, M. Effects of combined dietary supplementation on oxidative and inflammatory status in dyslipidemic subjects. Nutr Metab Cardiovasc.Dis. 2006;16(2):121-127. view abstract.
- Akiyama, Y., Hori, K., Hata, K., Kawane, M., Kawamura, Y., Yoshiki, Y., and Okubo, K. Screening of chemiluminescence constituents of cereals and DPPH radical scavenging activity of gamma-oryzanol. Luminescence. 2001;16(3):237-241. view abstract.
- Andoh, H., Sakamoto, Y., Asano, S., and Matsushita, H. Electroencephalographic studies in triterpene alcohol, a cerebral activator with a steroid compound, in rabbits and cats. Current Therapeutic Research, Clinical & Experimental 1994;55(11):1402-1413.
- Arai, T. [Effect of gamma-oryzanol on indefinite complaints in the gastrointestinal symptoms in patients with chronic gastritis--studies on the endocrinological environment (author's transl)]. Horumon To Rinsho 1982;30(3):271-279. view abstract.
- Berger, A., Rein, D., Schafer, A., Monnard, I., Gremaud, G., Lambelet, P., and Bertoli, C. Similar cholesterol-lowering properties of rice bran oil, with varied gamma-oryzanol, in mildly hypercholesterolemic men*. Eur J Nutr 2005;44(3):163-173. view abstract.
- Chen, C. W. and Cheng, H. H. A rice bran oil diet increases LDL-receptor and HMG-CoA reductase mRNA expressions and insulin sensitivity in rats with streptozotocin/nicotinamide-induced type 2 diabetes. J Nutr 2006;136(6):1472-1476. view abstract.
- Chen, P. H., Luo, M. L., Wong, C. K., and Chen, C. J. Polychlorinated biphenyls, dibenzofurans, and quaterphenyls in the toxic rice-bran oil and PCBs in the blood of patients with PCB poisoning in Taiwan. Am J Ind Med 1984;5(1-2):133-145. view abstract.
- Cicero, A. F. and Gaddi, A. Rice bran oil and gamma-oryzanol in the treatment of hyperlipoproteinaemias and other conditions. Phytother Res 2001;15(4):277-289. view abstract.
- Fujiwaki, T. and Furusho, K. An open study of gamm-oryzanol as a bath product for children with atopic dermatitis. Acta Paediatrica Hungarica 1993;33(3-4):287-298.
- Hayakawa, R. Clinical evaluation of FC-9201 cream containing 1.0% gamma-oryzanol. Skin Research 1993;35(1):131-154.
- Hayakawa, R., Suzuki, M., and Ogino, Y. Clinical evaluation of gamma-oryzanol on skin diseases with dry skin. Acata Dermatologica 1994;89(1):115-119.
- Hiraga, Y., Nakata, N., Jin, H., Ito, S., Sato, R., Yoshida, A., Mori, T., Ozeki, M., and Ikeda, Y. Effect of the rice bran-derived phytosterol cycloartenol ferulic acid ester on the central nervous system. Arzneimittelforschung 1993;43(7):715-721. view abstract.
- Hiramatsu, K., Tani, T., Kimura, Y., Izumi, S., and Nakane, P. K. Effect of gamma-oryzanol on atheroma formation in hypercholesterolemic rabbits. Tokai J Exp Clin Med 1990;15(4):299-305. view abstract.
- Hiramitsu, T. and Armstrong, D. Preventive effect of antioxidants on lipid peroxidation in the retina. Ophthalmic Res 1991;23(4):196-203. view abstract.
- Fukushima, S., Imaida, K., Ito, N., and Shirai, T. Modifying effects of phytic acid and gamma-oryzanol on the promotion stage of rat carcinogenesis. Anticancer Res 1999;19(5A):3665-3670. view abstract.
- Hirose, M., Hoshiya, T., Akagi, K., Futakuchi, M., and Ito, N. Inhibition of mammary gland carcinogenesis by green tea catechins and other naturally occurring antioxidants in female Sprague-Dawley rats pretreated with 7,12-dimethylbenz[alpha]anthracene. Cancer Lett. 8-15-1994;83(1-2):149-156. view abstract.
- Hirose, M., Ozaki, K., Takaba, K., Fukushima, S., Shirai, T., and Ito, N. Modifying effects of the naturally occurring antioxidants gamma-oryzanol, phytic acid, tannic acid and n-tritriacontane-16, 18-dione in a rat wide-spectrum organ carcinogenesis model. Carcinogenesis 1991;12(10):1917-1921. view abstract.
- Huang, D., Ou, B., Hampsch-Woodill, M., Flanagan, J. A., and Deemer, E. K. Development and validation of oxygen radical absorbance capacity assay for lipophilic antioxidants using randomly methylated beta-cyclodextrin as the solubility enhancer. J Agric.Food Chem 3-27-2002;50(7):1815-1821. view abstract.
- Ichimaru, Y., Moriyama, M., Ichimaru, M., and Gomita, Y. [Effects of gamma-oryzanol on gastric lesions and small intestinal propulsive activity in mice]. Nippon Yakurigaku Zasshi 1984;84(6):537-542. View abstract.
- Ieiri, T., Kase, N., Hashigami, Y., Kobori, H., Nakamura, T., and Shimoda, S. [Effects of gamma-oryzanol on the hypothalamo-pituitary axis in the rat]. Nippon Naibunpi Gakkai Zasshi 10-20-1982;58(10):1350-1356. View abstract.
- Itaya, K. and Kiyonaga, J. [Studies of gamma-oryzanol (1). Effects on stress-induced ulcer]. Nippon Yakurigaku Zasshi 1976;72(4):475-481. view abstract.
- Itaya, K., Kitonaga, J., and Ishikawa, M. [Studies of gamma-oryzanol. (2) The antiulcerogenic action]. Nippon Yakurigaku Zasshi 1976;72(8):1001-1011. View abstract.
- Itaya, K., Kiyonaga, J., Ishikawa, M., and Mizuta, K. [Studies on gamma-oryzanol. III. Influence of gamma-oryzanol on circadian rhythms of serum gastrin, 11-OHCS and gastric secretion in rats (author's transl)]. Nippon Yakurigaku Zasshi 1977;73(4):457-463. view abstract.
- Juliano, C., Cossu, M., Alamanni, M. C., and Piu, L. Antioxidant activity of gamma-oryzanol: mechanism of action and its effect on oxidative stability of pharmaceutical oils. Int J Pharm 8-11-2005;299(1-2):146-154. view abstract.
- Kaneta, H., Kujira, K., Shigenaga, T., and Itaya, K. [Effects of gamma-oryzanol on norepinephrine contents in the brain and stomach of rats (author's transl)]. Nippon Yakurigaku Zasshi 1979;75(4):399-403. view abstract.
- S. J., Han, D., Moon, K. D., and Rhee, J. S. Measurement of superoxide dismutase-like activity of natural antioxidants. Biosci.Biotechnol.Biochem 1995;59(5):822-826. view abstract.
- Kiribuchi, M., Miura, K., Tokuda, S., and Kaneda, T. Hypocholesterolemic effect of triterpene alcohols with soysterol on plasma cholesterol in rats. J Nutr Sci Vitaminol.(Tokyo) 1983;29(1):35-43. view abstract.
- Kitazume, H., Ageishi, Y., Iwama, T., Kubo, I., and Suzuki, A. [Ticlopidine may prevent subtotal or total occlusion of dilated lesions after percutaneous coronary angioplasty]. J Cardiol 1993;23(2):149-155. view abstract.
- Lichtenstein, A. H., Ausman, L. M., Carrasco, W., Gualtieri, L. J., Jenner, J. L., Ordovas, J. M., Nicolosi, R. J., Goldin, B. R., and Schaefer, E. J. Rice bran oil consumption and plasma lipid levels in moderately hypercholesterolemic humans. Arterioscler.Thromb. 1994;14(4):549-556. view abstract.
- Miller, A. and Engel, K. H. Content of gamma-oryzanol and composition of steryl ferulates in brown rice (Oryza sativa L.) of European origin. J Agric.Food Chem 10-18-2006;54(21):8127-8133. view abstract.
- Mizonishi, T. and Semba, T. [Effects of gamma-oryzanol on the movements of stomach and ileum in the dog (author's transl)]. Nippon Heikatsukin.Gakkai Zasshi 1980;16(1):47-55. View abstract.
- Mizuta, K. and Itaya, K. [Effects of gamma-oryzanol and atropine on gastric secretion stimulated by insulin or 2-deoxy-D-glucose (author's transl)]. Nippon Yakurigaku Zasshi 1978;74(4):517-524. view abstract.
- Mizuta, K., Kaneta, H., and Itaya, K. [Effects of gamma-oryzanol on gastric secretions in rats (author's transl)]. Nippon Yakurigaku Zasshi 1978;74(2):285-295. View abstract.
- Most, M. M., Tulley, R., Morales, S., and Lefevre, M. Rice bran oil, not fiber, lowers cholesterol in humans. Am J Clin Nutr 2005;81(1):64-68. view abstract.
- Nakamura, A., Shirai, T., Takahashi, S., Ogawa, K., Hirose, M., and Ito, N. Lack of modification by naturally occurring antioxidants of 3,2'-dimethyl-4-aminobiphenyl-initiated rat prostate carcinogenesis. Cancer Lett. 7-4-1991;58(3):241-246. view abstract.
- Nakayama, S., Manabe, A., Suzuki, J., Sakamoto, K., and Inagaki, T. Comparative effects of two forms of gamma-oryzanol in different sterol compositions on hyperlipidemia induced by cholesterol diet in rats. Jpn.J Pharmacol 1987;44(2):135-143. view abstract.
- Ng, S. S. and Figg, W. D. Antitumor activity of herbal supplements in human prostate cancer xenografts implanted in immunodeficient mice. Anticancer Res 2003;23(5A):3585-3590. view abstract.
- Parrado, J., Miramontes, E., Jover, M., Marquez, J. C., Angeles, Mejias M., Collantes, De Teran, Absi, E., and Bautista, J. Prevention of brain protein and lipid oxidation elicited by a water-soluble oryzanol enzymatic extract derived from rice bran. Eur J Nutr 2003;42(6):307-314. view abstract.
- Rong, N., Ausman, L. M., and Nicolosi, R. J. Oryzanol decreases cholesterol absorption and aortic fatty streaks in hamsters. Lipids 1997;32(3):303-309. view abstract.
- Rosenbloom, C., Millard-Stafford, M., and Lathrop, J. Contemporary ergogenic aids used by strength/power athletes. J Am Diet Assoc 1992;92(10):1264-1266. view abstract.
- Rukmini, C. and Raghuram, T. C. Nutritional and biochemical aspects of the hypolipidemic action of rice bran oil: a review. J Am Coll Nutr 1991;10(6):593-601. view abstract.
- Sakamoto, K., Tabata, T., Shirasaki, K., Inagaki, T., and Nakayama, S. Effects of gamma-oryzanol and cycloartenol ferulic acid ester on cholesterol diet induced hyperlipidemia in rats. Jpn.J Pharmacol 1987;45(4):559-565. view abstract.
- Scavariello, E. M. and Arellano, D. B. [Gamma-oryzanol: an important component in rice brain oil]. Arch Latinoam.Nutr 1998;48(1):7-12. view abstract.
- Seetharamaiah, G. S., Krishnakantha, T. P., and Chandrasekhara, N. Influence of oryzanol on platelet aggregation in rats. J Nutr Sci Vitaminol.(Tokyo) 1990;36(3):291-297. view abstract.
- Shinomiya, M., Morisaki, N., Matsuoka, N., Izumi, S., Saito, Y., Kumagai, A., Mitani, K., and Morita, S. Effects of gamma-oryzanol on lipid metabolism in rats fed high-cholesterol diet. Tohoku J Exp Med 1983;141(2):191-197. view abstract.
- Sierra, S., Lara-Villoslada, F., Olivares, M., Jimenez, J., Boza, J., and Xaus, J. Increased immune response in mice consuming rice bran oil. Eur J Nutr 2005;44(8):509-516. view abstract.
- Stedronsky, E. R. Interaction of bile acids and cholesterol with non-systemic agents having hypocholesterolemic properties. Biochim.Biophys.Acta 1-20-1994;1210(3):255-287. view abstract.
- Sugano, M. and Tsuji, E. Rice bran oil and cholesterol metabolism. J Nutr 1997;127(3):521S-524S. View abstract.
- Suh, M. H., Yoo, S. H., Chang, P. S., and Lee, H. G. Antioxidant activity of microencapsulated gamma-oryzanol on high cholesterol-fed rats. J Agric.Food Chem 12-14-2005;53(25):9747-9750. view abstract.
- Suwa, M., Inoue, H., Adachi, Y., Nagamine, Y., and Yamamoto, T. Treatment of hyperlipidemia with probucol, gamma-oryzanol or their combination. Medical Journal of Kinki University 1988;13(4 Suppl.):83-85.
- Tamagawa, M., Otaki, Y., Takahashi, T., Otaka, T., Kimura, S., and Miwa, T. Carcinogenicity study of gamma-oryzanol in B6C3F1 mice. Food Chem Toxicol. 1992;30(1):49-56. view abstract.
- Tamagawa, M., Shimizu, Y., Takahashi, T., Otaka, T., Kimura, S., Kadowaki, H., Uda, F., and Miwa, T. Carcinogenicity study of gamma-oryzanol in F344 rats. Food Chem Toxicol. 1992;30(1):41-48. view abstract.
- Tezuka, T. The clinical effects of bathquina for dry, scaly skin of atopic dermatitis patients. Skin Research 1992;34(5):624-638.
- Tsushimoto, G., Shibahara, T., Awogi, T., Kaneko, E., Sutou, S., Yamamoto, K., and Shirakawa, H. DNA-damaging, mutagenic, clastogenic and cell-cell communication inhibitory properties of gamma-oryzanol. J Toxicol.Sci 1991;16(4):191-202. view abstract.
- Umehara, K., Shimokawa, Y., and Miyamoto, G. Effect of gamma-oryzanol on cytochrome P450 activities in human liver microsomes. Biol Pharm Bull 2004;27(7):1151-1153. view abstract.
- Xu, Z. and Godber, J. S. Purification and identification of components of gamma-oryzanol in rice bran oil. J Agric.Food Chem 1999;47(7):2724-2728. view abstract.
- Xu, Z., Hua, N., and Godber, J. S. Antioxidant activity of tocopherols, tocotrienols, and gamma-oryzanol components from rice bran against cholesterol oxidation accelerated by 2,2'-azobis(2-methylpropionamidine) dihydrochloride. J Agric.Food Chem 2001;49(4):2077-2081. view abstract.
- Yamauchi, J., Takahara, J., Uneki, T., Yakushiji, W., Nakashima, Y., Miyoshi, M., and Ofuji, T. [The effect of gamma-oryzanol on rat pituitary hormone secretion (author's transl)]. Nippon Naibunpi Gakkai Zasshi 8-20-1980;56(8):1130-1139. view abstract.
- Yasukawa, K., Akihisa, T., Kimura, Y., Tamura, T., and Takido, M. Inhibitory effect of cycloartenol ferulate, a component of rice bran, on tumor promotion in two-stage carcinogenesis in mouse skin. Biol Pharm Bull 1998;21(10):1072-1076. view abstract.
- Yoshino, G., Kazumi, T., Amano, M., Tateiwa, M., Yamasaki, T., Takashima, S., Iwai, M., Hatanaka, H., and Baba, S. Effects of gamma-oryzanol and probucol on hyperlipidemia. Current Therapeutic Research, Clinical & Experimental 1989;45(6):975-982.
- Yoshino, G., Kazumi, T., Amano, M., Tateiwa, M., Yamasaki, T., Takashima, S., Iwai, M., Hatanaka, H., and Baba, S. Effects of gamma-oryzanol on hyperlipidemic subjects. Current Therapeutic Research, Clinical & Experimental 1989;45(4):543-552.
- Fry AC, et al. The effects of gamma-oryzanol supplementation during resistance exercise training. Int J Sport Nutr 1997;7:318-29. view abstract.
- Grunewald KK, Bailey RS. Commercially marketed supplements for bodybuilding athletes. Sports Med 1993;15:90-103. view abstract.
- Ishihara M, Ito Y, Nakakita T, et al [Clinical effect of gamma-oryzanol on climacteric disturbance- on serum lipid peroxides]. Nippon Sanka Fujinka Gakkai Zasshi 1982;34:243-51. view abstract.
- Sasaki J, Takada Y, Handa K, et al. Effects of gamma-oryzanol on serum lipids and apolipoproteins in dyslipidemic schizophrenics receiving major tranquilizers. Clin Ther 1990;12:263-8. view abstract.
- Seetharamaiah GS, Chandrasekhara N. Effect of oryzanol on cholesterol absorption and biliary and fecal bile acids in rats. Indian J Med Res 1990;92:471-5. view abstract.
- Shimomura Y, Kobayashi I, Maruto S, et al. Effect of gamma-oryzanol on serum TSH concentrations in primary hypothyroidism. Endocrinol Jpn 1980;27:83-6. View abstract.
- Sugano M, Koba K, Tsuji E. Health benefits of rice bran oil. Anticancer Res 1999;19:3651-7. view abstract.Sugano M,
- Tsuji E. Rice bran oil and human health. Biomed Environ Sci 1996;9:242-6. view abstract.
- Wheeler KB, Garleb KA. Gamma oryzanol-plant sterol supplementation: metabolic, endocrine, and physiologic effects. Int J Sport Nutr 1991;1:170-7. view abstract.