Verbena
Vervain, also known as pigeon herb, cat's blood herb, legend herb and wishing herb, as well as by its Latin name Verbena officinalis, is a plant whose parts growing above the ground are used to make medicine. Verbena is used to treat sore throats and respiratory diseases such as asthma and whooping cough, as well as heart conditions such as chest pain (angina) and water retention due to heart failure. Vervain is also used for depression, hysteria, seizures, pain in the gallbladder area, gout, metabolic disorders, anemia and fever, as well as for recovery after a fever. Other uses include the treatment of pain, cramps, exhaustion, nervous disorders, digestive disorders, liver and gallbladder disorders, jaundice and disorders of the kidneys and urinary tract. Women use vervain to treat symptoms of menopause, irregular menstruation and to increase milk flow during breastfeeding. Some people apply vervain directly to the skin to treat poorly healing wounds, abscesses and burns, as well as arthritis, rheumatic joint pain, sprains, bruises and itching. Verbena is also used as a gargle solution for cold symptoms and other ailments in the mouth and throat. In combination with sorrel, cowslip, gentian root and elderflower, verbena is used to maintain the health of the sinuses and to treat sinusitis.
In industrial production, verbena flowers are used as a flavoring agent in alcoholic beverages.
How does verbena work?
Vervain contains chemicals that may reduce inflammation.
How effective is vervain?
Vervain may be effective when used in the form of a combination product containing elderflower, gentian root, sorrel and primrose (Sinupretp) to treat sinusitis. The use of this combination product appears to be effective in the treatment of acute or chronic sinusitis.
There is not enough scientific data to make a statement about the effectiveness of vervain for sore throats, asthma, whooping cough, chest pain, abscesses, burns, colds, arthritis and itching. Further scientific research is needed to evaluate the effectiveness of vervain in these applications.
Safety and side effects
Vervain appears to be safe for most people when used in small amounts as part of a combination product containing sorrel, cowslip, gentian root and elderflower (Sinupret). However, there is not enough information on whether verbena is safe and harmless when used in medicinal quantities in a form other than the combination product mentioned. The combination product mentioned may cause indigestion and occasionally allergic skin rash.
Precautions and warnings
Pregnancy and lactation: Not enough is known about the use of vervain during pregnancy and lactation. For this reason, pregnant and breastfeeding women should avoid verbena.
Interactions
At the present time there is no information on interactions of vervain with medications or supplements.
Dosage
The following dosages have been investigated in scientific studies:
Oral:
- For infections of the paranasal sinuses: A specific combination product (Sinupret) containing 36 mg elderflower, 12 mg gentian root and 36 mg each of sorrel, cowslip and vervain, three times daily.
References
- Carnat, A., Carnat, A. P., Chavignon, O., Heitz, A., Wylde, R., and Lamaison, J. L. Luteolin 7-diglucuronide, the major flavonoid compound from Aloysia triphylla and Verbena officinalis. Planta Med 1995;61(5):490. view abstract.
- Castro-Gamboa, I. and Castro, O. Iridoids from the aerial parts of Verbena littoralis (Verbenaceae). Phytochemistry 2004;65(16):2369-2372. view abstract.
- De Oliveira, A. C., Ribeiro-Pinto, L. F., and Paumgartten, J. R. In vitro inhibition of CYP2B1 monooxygenase by beta-myrcene and other monoterpenoid compounds. Toxicol Lett 6-16-1997;92(1):39-46. view abstract.
- De Oliveira, A. C., Ribeiro-Pinto, L. F., Otto, S. S., Goncalves, A., and Paumgartten, F. J. Induction of liver monooxygenases by beta-myrcene. Toxicology 12-26-1997;124(2):135-140. view abstract.
- el Hela, A. A., Sowinski, P., and Krauze-Baranowska, M. Iridoids and phenylethanoids of Verbena bipinnatifida nutt. Acta Pol.Pharm. 2000;57(1):65-68. View abstract.
- Grases, F., Melero, G., Costa-Bauza, A., Prieto, R., and March, J. G. Urolithiasis and phytotherapy. Int Urol Nephrol 1994;26(5):507-511. view abstract.
- Guarrera, P. M., Forti, G., and Marignoli, S. Ethnobotanical and ethnomedicinal uses of plants in the district of Acquapendente (Latium, Central Italy). J Ethnopharmacol. 1-15-2005;96(3):429-444. view abstract.
- Kawashty, S. A. and El Garf, I. A. The flavonoid chemosystematics of Egyptian Verbena species. Biochem.Syst.Ecol. 11-1-2000;28(9):919-921. view abstract.
- KING, N. M., CHATTERJEE, A., and PARKS, L. M. A note on the isolation of ursolic acid from Verbena stricta, Vent. J Am.Pharm.Assoc.Am.Pharm.Assoc. 1950;39(10):595. view abstract.
- Li, Y. and Ohizumi, Y. Search for constituents with neurotrophic factor-potentiating activity from the medicinal plants of paraguay and Thailand. Yakugaku Zasshi 2004;124(7):417-424. view abstract.
- Li, Y. S., Matsunaga, K., Ishibashi, M., and Ohizumi, Y. Littoralisone, a novel neuritogenic iridolactone having an unprecedented heptacyclic skeleton including four- and nine-membered rings consisting of glucose from Verbena littoralis. J Org.Chem. 3-23-2001;66(6):2165-2167. view abstract.
- Li, Y. S., Matsunaga, K., Kato, R., and Ohizumi, Y. Potentiation of nerve growth factor-induced elongation of neurites by gelsemiol and 9-hydroxysemperoside aglucone in PC12D cells. J Pharm Pharmacol 2001;53(6):915-919. view abstract.
- Li, Y. S., Matsunaga, K., Kato, R., and Ohizumi, Y. Verbenachalcone, a novel dimeric dihydrochalcone with potentiating activity on nerve growth factor-action from Verbena littoralis. J Nat Prod 2001;64(6):806-808. view abstract.
- Li, Y., Ishibashi, M., Chen, X., and Ohizumi, Y. Littorachalcone, a new enhancer of NGF-mediated neurite outgrowth, from Verbena littoralis. Chem.Pharm.Bull.(Tokyo) 2003;51(7):872-874. view abstract.
- Li, Y., Ishibashi, M., Satake, M., Chen, X., Oshima, Y., and Ohizumi, Y. Sterol and triterpenoid constituents of Verbena littoralis with NGF-potentiating activity. J Nat Prod 2003;66(5):696-698. view abstract.
- Li, Y., Ishibashi, M., Satake, M., Oshima, Y., and Ohizumi, Y. A new iridoid glycoside with nerve growth factor-potentiating activity, gelsemiol 6'-trans-caffeoyl-1-glucoside, from Verbena littoralis. Chem.Pharm.Bull.(Tokyo) 2003;51(9):1103-1105. view abstract.
- Liu, C. H. and Liu, Y. [Determination of ursolic acid in herba of Verbena officinalis by HPLC]. Zhongguo Zhong.Yao Za Zhi. 2002;27(12):916-918. View abstract.
- Mangion, I. K. and MacMillan, D. W. Total synthesis of brasoside and littoralisone. J Am Chem Soc 3-23-2005;127(11):3696-3697. view abstract.
- Michael, H. N., Salib, J. Y., and Ishak, M. S. New methoxyflavone glycosides from Verbena bipinnatifida Nutt. Pharmacy 2001;56(4):348-349. view abstract.
- Miyazawa, M., Sugie, A., and Shimada, T. Roles of human CYP2A6 and 2B6 and rat CYP2C11 and 2B1 in the 10-hydroxylation of (-)-verbenone by liver microsomes. Drug Metab Dispos. 2003;31(8):1049-1053. view abstract.
- Paumgartten, F. J., De Carvalho, R. R., Souza, C. A., Madi, K., and Chahoud, I. Study of the effects of beta-myrcene on rat fertility and general reproductive performance. Braz.J Med Biol Res 1998;31(7):955-965. view abstract.
- Potter, P. C., Mather, S., Lockey, P., and Knottenbelt, J. D. IgE-mediated contact hypersensitivity to a 62-kilodalton allergen in Verbena hybrida. S.Afr.Med J 1992;82(6):482. view abstract.
- Potter, P. C., Mather, S., Lockey, P., Knottenbelt, J. D., Paulsen, E., Skov, P. S., and Andersen, K. E. Immediate and delayed contact hypersensitivity to verbena plants. Contact Dermatitis 1995;33(5):343-346. view abstract.
- Prakash, A. O. [Biological evaluation of some medicinal plant extracts for contraceptive efficacy in females]. Contracept.Fertil.Sex (Paris) 1985;13(4):649-655. View abstract.
- Tian, J., Zhao, Y. M., and Luan, X. H. [Studies on the chemical constitutents in herb of Verbena officinalis]. Zhongguo Zhong.Yao Za Zhi. 2005;30(4):268-269. View abstract.
- WINDE, E., ECHAUST, I., and HAENSEL, R. [Verbena officinalis: occurrence of adenosine and beta-carotene. On the problem of "verbenin" described by Kuwajima]. Arch Pharm. 1961;294/66:220-229. View abstract.
- Zhang, T., Ruan, J. L., and Lu, Z. M. [Studies on chemical constituents of aerial parts of Verbena officinalis L.]. Zhongguo Zhong.Yao Za Zhi. 2000;25(11):676-678. View abstract.
- Argento A, Tiraferri E, Marzaloni M. [Oral anticoagulants and medicinal plants. An emerging interaction]. Ann Ital Med Int. 2000;15:139-43. view abstract.
- Auf'mkolk M, Ingbar JC, Amir SM, et al. Inhibition by certain plant extracts of the binding and adenylate cyclase stimulatory effect of bovine thyrotropin in human thyroid membranes. Endocrinology. 1984 Aug;115:527-34. view abstract.
- Chiou WF, Lin LC, Chen CF. Acteoside protects endothelial cells against free radical-induced oxidative stress. J Pharm Pharmacol 2004;56:743-8. view abstract.
- Deepak M, Handa SS. Anti-inflammatory activity and chemical composition of extracts of Verbena officinalis. Phytother Res 2000;14:463-5. View abstract.
- Del Pozo MD, Gastaminza G, Navarro JA, et al. Allergic contact dermatitis from Verbena officinalis L. Contact Dermatitis 1994;31:200-1. View abstract.
- Dudai N, Weinstein Y, Krup M, et al. Citral is a new inducer of caspase-3 in tumor cell lines. Planta Med 2005;71:484-8. View abstract.
- Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: http://ecfr.gpoaccess.gov/cgi/t/text/text-idx?c=ecfr&sid= 786bafc6f6343634fbf79fcdca7061e1&rgn=div5&view= text&node=21:3.0.1.1.13&idno=21
- Hernandez NE, Tereschuk ML, Abdala LR. Antimicrobial activity of flavonoids in medicinal plants from Tafi del Valle (Tucuman, Argentina). J Ethnopharmacol 2000;73:317-22. view abstract.
- Hurrell RF, Reddy M, Cook JD. Inhibition of non-haem iron absorption in man by polyphenolic-containing beverages. Br J Nutr 1999;81:289-95. view abstract.
- Lee KJ, Woo ER, Choi CY, et al. Protective effect of acteoside on carbon tetrachloride-induced hepatotoxicity. Life Sci 2004;74:1051-64. view abstract.
- Marz RW, Ismail C, Popp MA. Action profile and efficacy of a herbal combination preparation for the treatment of sinusitis. Wien Med Wochenschr 1999;149:202-8. View abstract.
- Nakamura T, Okuyama E, Tsukada A, et al. Acteoside as the analgesic principle of Cedron (Lippia triphylla), a Peruvian medicinal plant. Chem Pharm Bull 1997;45:499-504.
- Neubauer N, Marz RW. Placebo-controlled, randomized, double-blind, clincal trial with Sinupret sugar coated tablets on the basis of a therapy with antibiotics and decongestant nasal drops in acute sinusitis. Phytomedicine 1994;1:177-81.
- Zava DT, Dollbaum CM, Blen M. Estrogen and progestin bioactivity of foods, herbs, and spices. Proc Soc Exp Biol Med 1998;217:369-78. view abstract.