Health

Can vitamin D reduce the risk of COVID-19?
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Experts are investigating whether vitamin D deficiency is linked to severe Covid-19 symptoms. Here is a brief overview:

  • Several studies have linked vitamin D deficiency to both coronavirus infections and more severe disease progression in codid-19 disease

  • Scientists are investigating whether vitamin D supplementation could help protect against severe Covid-19 symptoms

  • Even before these studies are completed, there are good reasons to consider using a vitamin D supplement

With no coronavirus vaccine yet available, many people are turning to vitamins and other supplements to protect their immune system and help it keep Covid-19 at bay.

Even though many social media posts tout these supplements as a personal shield, experts like American virologist and director of the National Institute of Allergy and Infectious Diseases Dr. Fauci say that most of these immune-boosting supplements won't do much.

However, there is one supplement that can be beneficial to our immune system - vitamin D, also known as the sunshine vitamin. If you suffer from a vitamin D deficiency, this will affect your susceptibility to infections. For this reason, experts such as Dr. Fauci also recommend taking vitamin D supplements.

Even if these statements are often not made directly in connection with Covid-19, the general role of vitamin D in supporting the immune system and especially its benefits for people suffering from a vitamin D deficiency should not be underestimated.

Although the US Food and Drug Administration says there is no clear evidence yet that vitamin D can protect against Covid-19, there is so much evidence that scientists are intensively investigating the potential benefits of vitamin D and other supplements in relation to coronavirus.

Vitamin D deficiency is associated with COVID-19

Early research has shown that vitamin D can reduce the risk of respiratory infections (which include COVID-19) (1). The benefits varied between these studies, but vitamin D supplementation appeared to be more helpful for those suffering from vitamin D deficiency.

More recent research suggests that vitamin D deficiency may increase the risk of coronavirus infection and worsen the severity of COVID-19 disease.

Dr. Luigi Gennari, a professor in the Department of Medicine and Neuroscience at the University of Sienna in Italy, recently presented data at a meeting of the American Society for Bone and Mineral Research showing a possible relationship between low vitamin D levels and an increased risk of more severe COVID-19 courses.

The American scientist said that people who came to the intensive care unit at Santa Luca Hospital in Milan with severe COVID-19 symptoms had lower 25-hydroxyvitamin D levels and higher interleukin 6 levels (a protein produced in the body in connection with inflammation) than patients who had milder symptoms and did not come to the intensive care unit.

People who died of COVID-19 in this hospital had lower vitamin D levels on average than patients who survived.

Some studies have found, for example, that the number of COVID-19 deaths is higher in countries further away from the equator (2), where many people suffer from a vitamin deficiency due to reduced sun exposure, especially in winter (3).

Our body produces its own vitamin D when the skin is exposed to sunlight and many people can easily develop a deficiency in winter with reduced sun exposure.

While it is possible that other factors may also contribute to the higher COVID-19 case numbers in northern countries, a recent study published in JAMA Network supports the importance of vitamin D for a healthy immune system (4).

"In our study, patients with lower vitamin D levels had a higher risk of testing positive for COVID-19," said study author Dr. David Meltzer of the University of Chicago Medicine.

This trend continued even when the researchers tried to control for other factors such as age, obesity or other medical conditions that can exacerbate COVID-19 disease and are associated with low vitamin D levels.

Other studies show that patients with lower vitamin D levels who have been diagnosed with COVID-19 tend to have a poorer prognosis for disease progression.

One of these studies was recently published in the journal PLoS ONE (5). Researchers found that people who had been hospitalized for COVID-19 and were vitamin D deficient were more likely to develop severe COVID-19 symptoms or die.

However, not all research supports this link between vitamin D and COVID-19. For example, a recent study published in Diabetes & Metabolic Syndrome: Clinical Research & Reviews found no association between vitamin D levels and coronavirus disease (6).

However, Meltzer and his colleagues emphasized in their publication that the authors of the study had carried out the vitamin D levels up to 14 years before the COVID-19 tests and had not asked whether the subjects had been treated with vitamin D in the meantime. This could weaken the observations regarding the undetectable link between vitamin D and COVID-19.

Scientists are also investigating other nutrients as potential treatments for COVID-19, including zinc and vitamin C, which are known for their beneficial properties against the common cold.

In a study from Spain, scientists reported that patients with low zinc blood levels were at higher risk of death from Covid-19 (7).

Studies investigate the benefits of vitamin D

These studies are observational, meaning that scientists collected data from people over time rather than dividing subjects into different treatment groups. This makes it impossible to show a direct cause-and-effect relationship between vitamin D and COVID-19.

The latter requires randomized controlled trials, the "gold standard" of clinical trials, some of which are already being planned or conducted.

In a Spanish study, researchers administered calcifediol - an active form of vitamin D - to 50 patients hospitalized with COVID-19 (8). Another group of 26 patients received no vitamin D.

All patients were treated equally with hydroxychloroquine and azithromycin. Only one of the vitamin D-treated patients ended up in intensive care, while half of the untreated patients ended up in intensive care.

One of the authors of the study concluded: "Our pilot study has shown that the administration of high doses of vitamin D in the form of calcifediol or 25-hydroxyvitamin D can significantly reduce the need for ICU treatment for COVID-19 patients."

While this study has a few limitations - it's not particularly large and there was a slight imbalance between the groups - it's still quite impressive.

While this study used vitamin D to treat people who already had COVID-19, scientists believe that vitamin D could work just as well when it comes to preventing people from being hospitalized in the first place.

One possibility could be that while vitamin D does not prevent COVID-19, it means that people who are infected show such minimal symptoms that they are never tested and the disease goes undiagnosed.

However, further scientific research is needed to find out whether this is actually the case.

Two randomized controlled trials being conducted at the University of Chicago should provide some answers. In both studies, patients are treated with vitamin D and then observed to see if they contract COVID-19 and how severe their symptoms are.

One study focuses on healthcare workers, while the other focuses on "regular citizens" with an emphasis on people of African-American and Hispanic descent who are at increased risk for both vitamin D deficiency and COVID-19.

Scientists at the Cleveland Clinic are looking for volunteers for a study to investigate whether vitamin C or zinc - or a combination of both - can reduce the duration of COVID-19 symptoms. Patients in this study will receive the supplements after testing positive for COVID-19.

Should you use vitamin D supplements?

Even before these studies are completed, there are good reasons to consider taking a vitamin D supplement.

The vast majority of people in our latitudes are vitamin D deficient and could therefore benefit from adequate vitamin D supplementation. In America, for example, an estimated 41% of all adults are vitamin D deficient and in Central Europe the figures are no better (9).

People of darker skin color are at even higher risk, as reflected in the fact that 63% of Hispanics and 82% of African-Americans in America have low vitamin D levels.

Other factors for increased risk of vitamin D deficiency include age, limited sun exposure, obesity and certain medical conditions.

In addition, it is difficult to get vitamin D from food, as even the richest food sources only contain trace amounts of this vitamin.

Zinc can also be helpful if you are experiencing symptoms of an impending cold. In this case, some doctors recommend taking between 12 and 25 mg of zinc every two hours for as long as you experience cold symptoms, but no longer than two weeks.

As with vitamin D, it is not yet 100% known whether zinc can reduce COVID-19 symptoms.

While most people get enough zinc from food, some groups of people such as vegetarians, people with digestive tract conditions and people who abuse alcohol are at higher risk of zinc deficiency and should therefore consider taking a zinc supplement.

A recent meta-analysis of 40 scientific studies concluded that daily, long-term doses of vitamin D protect against acute respiratory infections (10).

How vitamin D helps

Vitamin D plays an important role in keeping us healthy and fighting disease in the least destructive way by regulating the immune response without provoking an immune system overreaction such as a cytokine storm, which is often associated with severe COVID-19 disease.

Vitamin D steers the immune system away from highly inflammatory pathways towards pathways that are more regulated.

Although it is best to get vitamin D from natural sources, supplements can also be effective in supporting the immune system.

Health experts also recommend having your body's vitamin D levels tested by a doctor. In times like these, it's more important than ever to know what's going on in your body. Vitamin D could help prevent COVID-19 from harming you or other people.

References:

  1. https://www.bmj.com/content/356/bmj.i6583
  2. https://nutrition.bmj.com/content/early/2020/06/14/bmjnph-2020-000110
  3. https://www.tandfonline.com/doi/abs/10.3402/ijch.v67i2-3.18258
  4. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2770157
  5. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0239799
  6. https://www.sciencedirect.com/science/article/pii/S1871402120301156
  7. https://www.eurekalert.org/pub_releases/2020-09/esoc-lzl092220.php
  8. https://www.sciencedirect.com/science/article/pii/S0960076020302764
  9. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075634/
  10. https://www.medrxiv.org/content/10.1101/2020.07.14.20152728v1

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Supplements to support immunity to respiratory diseases such as COVID-19
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We have noticed a lot of misinformation being spread recently about immune function and respiratory diseases such as COVID-19 and feel it is time to set the record straight. Respiratory diseases affect the nasal mucosa, airways or lungs and encompass a wide range of conditions from the common cold to pneumonia. The immune system is a complex network of cells, body tissues and organs that work together to protect your body on a daily basis from infections such as those mentioned above.

Scientific research shows that certain supplements can reduce the risk of infection and the severity of symptoms. In this article, we will discuss supplements that have been scientifically proven to safely support your immune system.

As always, it is recommended that you consult a doctor before starting any supplement program if you have a medical condition, suspect you have a medical condition or are taking any medications.

Fermented foods, probiotics and prebiotics can have anti-inflammatory and anti-pathogenic effects

Your digestive tract contains a rich community of healthy microbes that fight off outside invading pathogens and act as the body's first line of defense against infection. In addition, through a process called fermentation, they digest nutrients like fiber and other carbohydrates that you otherwise could not, resulting in the production of byproducts that play many important roles in the human body, ranging from protecting the gut to improving insulin sensitivity.

Recent research has found that your gut flora is a key component of a healthy immune system and your body's ability to fight viral and bacterial infections. Both probiotic supplements and fermented foods, which are a source of live bacteria, can significantly reduce your risk of infection by fighting pathogens in the gut and contributing to anti-inflammatory pathways throughout the body.

Certain strands of bacteria have stronger infection-protective and anti-inflammatory effects than others. Lactobacillus plantarum, Bifidobacterium lactis, Lactobacillus casei and Lactobacillus rhamnosus (also known as Lactobasciullus GG) are among the best "fighters" against viral infections in general and upper respiratory tract infections in particular (1, 2, 3, 4).

If you are considering using a probiotic supplement, then you should look for a product that contains at least one or two or more of the above-mentioned strands of probiotic bacteria.

Your diet can also be an important tool for supporting healthy gut flora. Fermented foods such as kimchi, sauerkraut, miso and tempeh, as well as yogurt and kefir can directly add healthy bacteria to your gut, while prebiotic supplements and foods such as beans and cruciferous vegetables can help these bacteria to thrive better in your gut.

Zinc can help make infections less severe

Zinc plays an important role in immune function as it is involved in the cell-mediated and humoral immune response - two types of immunity in which an immune response specific to a particular pathogen is generated. Low zinc levels or a zinc deficiency can therefore reduce the number of your immune cells available to fight pathogens that invade the body.

After a review of 13 randomized, placebo-controlled trials on zinc and the common cold, researchers concluded that taking zinc within the first 24 hours of the first cold symptoms can reduce the duration of the cold and alleviate the symptoms of the illness (5).

Men need about 11 mg and women about 8 mg of zinc per day. Zinc is primarily found in red meat and seafood - especially oysters and molluscs. Zinc is also found in plant sources such as whole grains and pulses - albeit in smaller quantities. In addition, zinc from plant sources is less easily absorbed by the body than zinc from animal sources. Vegetarians and older people are at a higher risk of inadequate dietary zinc intake.

Although it is important to meet your daily zinc requirements, it is equally important not to overdo it with your zinc intake. The maximum amount of zinc you should consume per day is 40 mg. A higher intake can lead to copper deficiency and neurological problems (6, 20).

If you are struggling to meet your daily zinc requirements or are experiencing the first signs of a cold, it may be useful to take 25 mg of zinc per day. Zinc supplements are best taken on an empty stomach.

Vitamin C can support the immune system

You can't talk about immune function without mentioning vitamin C. Just like zinc, vitamin C is an essential micronutrient that must be obtained from the diet. Vitamin C plays an important role in immune function by acting as an antioxidant, improving immune cell function and supporting anti-inflammatory pathways in the body.

Vitamin C deficiency can lead to impaired immune function and increased susceptibility to infections. A study review (19) looked at hundreds of studies examining the role of vitamin C in immune function. The researchers concluded that supplementation with 100 to 200 mg of vitamin C per day can prevent respiratory infections.

Many supplements contain 1,000 mg of vitamin C per tablet or capsule. The bad news is that the absorption of vitamin C decreases with increasing intake. For example, at a high intake (around 1,200 mg) only 16% is absorbed, whereas at a low intake (< 20 mg) 98% is absorbed. As soon as you reach 1,000 mg, less than 50% of the vitamin C intake is excreted in the urine (20). For this reason, vitamin C is best taken in two to three smaller doses with meals.

Toxicity does not usually occur with vitamin C, but undesirable side effects can occur if the upper tolerated amount (2,000 mg per day) is exceeded over the long term (7).

Vitamin C is most abundant in fresh, whole foods such as pineapple, kiwi and broccoli. For this reason, it is not surprising that a lack of consumption of fresh foods, among other causes, has contributed to vitamin C deficiency being one of the leading nutrient deficiencies in the Western world (19).

As a water-soluble vitamin, vitamin C cannot be stored in the body. For this reason, it is important to consume foods rich in vitamin C every day to meet daily requirements.

Adequate vitamin C intake is essential for the proper functioning of the immune system. If you are concerned about not getting the necessary amount of vitamin C, you should consider taking two to three smaller servings (200 mg) of vitamin C daily.

Vitamin D supplementation can protect the upper respiratory tract

Studies show that people with optimal vitamin D levels are less susceptible to colds and other respiratory infections than those with low vitamin D levels. In a systemic randomized review (the gold standard of scientific research), vitamin D supplementation appeared to protect against acute respiratory infections such as the common cold. This was particularly true for people who were previously vitamin D deficient (8).

In addition, it was observed that the likelihood of developing upper respiratory tract infections was inversely proportional to the serum (blood) levels of vitamin D. In other words, this means that the likelihood of respiratory tract infection increases as your vitamin D levels decrease (9). Serum vitamin D levels should be above 32 ng/ml for optimal health.

The bottom line is that optimal vitamin D levels could protect you from respiratory infections. You should therefore aim for an intake of at least 1,000 IU of vitamin D per day, with many experts recommending significantly higher amounts in the range of 2,000 to 4,000 IU per day.

Natural food sources of vitamin D include cod liver oil, oily fish, mushrooms and egg yolks. However, apart from cod liver oil and natural sun exposure, the low levels of natural vitamin D in the diet mean that supplementation with vitamin D is the only way to achieve optimal levels.

Ginseng can relieve symptoms of upper respiratory tract infections in the elderly

Ginseng is a root with strong antioxidant effects that contribute to reduced inflammation, immune function support and other health benefits. Several studies have shown positive effects of ginseng on colds and respiratory infections.

In a systemic review that looked at several studies, researchers concluded that ginseng extract can reduce the duration of a cold (10). The same results were replicated in a randomized double-blind control study in which subjects were given ginseng extract for four months (11). Of particular relevance is that ginseng was able to reduce both the risk and duration of respiratory symptoms in older people by 48% and 55% respectively (12).

Ginseng could therefore be particularly helpful for older people. It works best when taken within a two-hour window around a meal. An optimal dosage is 2,000 mg of ginseng extract per day.

Garlic can activate genes associated with immune function and reduce the likelihood of disease

Garlic has been used by many different cultures in the past to fight infectious diseases due to its antimicrobial, antifungal and antiviral properties (13). Modern studies have shown that garlic can activate immune system genes and reduce both the severity and risk of colds.

In a randomized double-blind study, subjects were given a garlic supplement or a placebo over a 12-week period from November to February - the flu and cold season. The group that received garlic had fewer cases of illness and also recovered more quickly from colds than the placebo group (14).

In a similar study design, after 45 days of garlic supplementation, subjects showed significantly improved function of NK and T cells, both of which are involved in immune function, compared to the placebo group. After 90 days, the garlic group also had fewer cold symptoms, sick days and number of colds than the placebo group (15). Finally, another study found that adding garlic to meals activated genes associated with immune function (16).

You can either add garlic to your diet in its natural form, or use supplements that contain garlic extracts in concentrated form and also do not cause garlic odor. A good dosage is 500mg of garlic extract twice a day with breakfast and dinner.

The facts about elderberry and echinacea are not yet clear

Elderberry syrup has recently appeared in the spotlight as a natural way to support the immune system. The flowers and berries of the Sambucus nigra species have been most commonly studied and used in tea or syrup.

However, only a handful of small studies (about four) have been conducted to date. Although the results were positive - elderberry supplementation can reduce the duration and severity of upper respiratory symptoms - the amounts used varied from study to study (17).

In one study, for example, 300 mg of elderberry extract was used, while in another study 60 ml of elderberry syrup was used for five consecutive days. Sambucol, one of the most popular commercially available elderberry syrup products, contains just 3.8 mg of elderberry per 10 ml serving - and a full 8 grams of sugar. Even if taken several times a day, this would not be enough to reach the levels used in clinical trials.

And now something about echinacea. In a meta-analysis that looked at 24 randomized controlled trials, scientists concluded that echinacea could not be shown to have benefits in the treatment of the common cold.

Furthermore, in 2003, a study made headlines when scientists looked at 59 different echinacea supplements available on the market. They found that only 52% of the products tested contained the amounts of echinacea stated on the label and 19% contained no echinacea at all (18).

Due to the lack of studies on elderberry and the inconclusive results on echinacea, these two plant extracts cannot be recommended for treating colds or supporting the immune system at this time.

So which supplements can support the immune system?

Scientists who have studied the effectiveness of different supplements for fighting colds, flu, respiratory infections and other related symptoms are largely in agreement: taken daily, the following supplements are associated with a reduced risk of infection, reduced duration and reduced severity of symptoms, with each of these supplements having different unique properties that can support the immune system:

  • Probiotics
  • Zinc
  • Vitamin C
  • Vitamin D
  • ginseng
  • Garlic

We hope this summary will help you choose wisely and put you in the best position to protect yourself from contracting COVID-19 or other respiratory illnesses.

References:

  1. 19747410 Consumption of a fermented dairy product containing the probiotic Lactobacillus casei DN-114001 reduces the duration of respiratory infections in the elderly in a randomized controlled trial. https://www.ncbi.nlm.nih.gov/pubmed/19747410
  2. 20803023 Randomised, double-blind and placebo-controlled study using new probiotic lactobacilli for strengthening the body immune defence against viral infections.https://www.ncbi.nlm.nih.gov/pubmed/20803023
  3. 23020819 Effect of Lactobacillus rhamnosus LGG® and Bifidobacterium animalis ssp. lactis BB-12® on health-related quality of life in college students affected by upper respiratory infections. https://www.ncbi.nlm.nih.gov/pubmed/23020819
  4. 25927096 Probiotics for preventing acute upper respiratory tract infections. https://www.ncbi.nlm.nih.gov/pubmed/25927096
  5. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3273967/
  6. https://ods.od.nih.gov/factsheets/Zinc-HealthProfessional/
  7. https://ods.od.nih.gov/factsheets/VitaminC-HealthProfessional/
  8. https://pubmed.ncbi.nlm.nih.gov/28202713
  9. https://pubmed.ncbi.nlm.nih.gov/19237723
  10. https://www.ncbi.nlm.nih.gov/pubmed/19592479
  11. https://www.ncbi.nlm.nih.gov/pubmed/16247099
  12. https://pubmed.ncbi.nlm.nih.gov/16566675/
  13. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103721/
  14. https://www.ncbi.nlm.nih.gov/pubmed/11697022
  15. https://www.ncbi.nlm.nih.gov/pubmed/22280901
  16. https://www.ncbi.nlm.nih.gov/pubmed/26423732
  17. https://www.ncbi.nlm.nih.gov/pubmed/30670267
  18. https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/215276
  19. https://www.ncbi.nlm.nih.gov/pubmed/29099763
  20. Groff. Advanced Nutrition and Human Metabolism. Australia: Wadsworth/Cengage Learning, 2009. print.

Source: https://blog.insidetracker.com/supplements-support-immunity-against-respiratory-infection

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Here's what happens after your body is infected with the coronavirus
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  • Coronaviruses cause respiratory diseases, which is why the lungs are usually affected first
  • Early symptoms include fever, cough and shortness of breath. These symptoms can appear as early as 2 days or as late as 14 days after exposure to the virus
  • However, damage can also occur in other areas of the body, especially during severe courses of the disease

There are still a lot of things we don't know about the novel coronavirus, which has already infected over 500,000 people worldwide and killed thousands.

But one thing is clear - in severe cases, the virus can have devastating effects on the body, affecting far more than just the lungs. Here's what we know so far about how COVID-19 can affect different systems of the body.

COVID-19 affects the lungs

Like other coronavirus diseases including SARS and MERS, COVID-19 is a respiratory disease, which is why the lungs are usually affected first.

Early symptoms include fever, cough and shortness of breath. These symptoms can appear as early as 2 days after the initial infection or as late as 14 days later (1).

The severity of COVID-19 disease ranges from mild or no symptoms to severe and sometimes fatal disease progression. Initial data from China found that around 81 of those infected had a mild course of the disease, while the remaining cases had a severe or critical course (2).

Older people or people suffering from chronic diseases have a higher risk of a serious course of the disease (3).

This variability is also reflected in how COVID-19 affects the lungs. Some people have only mild respiratory symptoms, while others develop non-life-threatening pneumonia (4). However, there is also a subgroup of patients who develop severe lung damage.

"What we regularly see in patients who are seriously ill with COVID-19 is a condition called acute respiratory distress syndrome - ARDS for short," says Dr. Laura E. Evens, a member of the Society of Critical Care Medicine Leadership Council at the University of Washington Medical Center in Seattle.

However, ARDS is not unique to COVID-19. A whole range of events including infections, trauma and sepsis can trigger this syndrome (5).

ARDS causes lung damage, which results in fluid leaking from the small blood vessels in the lungs. This fluid accumulates in the air sacs of the lungs, making it difficult for the lungs to transfer oxygen from the air into the blood.

Although there is not yet enough information about the type of lung damage that occurs in the lungs during COVID-19 disease, a recent report suggests that this damage is similar to that observed in SARS and MERS (6).

A recent source that looked at 138 patients hospitalized for COVID-19 concluded that patients began to experience respiratory distress on average 5 days after the first symptoms (7). ARDS developed on average 8 days after the onset of symptoms.

Treatment for ARDS includes oxygen supplementation and mechanical ventilation with the aim of getting more oxygen into the blood (8).

There is no specific treatment for ARDS. They simply try to support the patient through the process as best they can and allow the body to heal while the immune system fights the underlying cause.

Other organs attacked by COVID-19

The lungs are the primary organ attacked by COVID-19, but in serious cases of illness the rest of the body can also be affected. Of the patients who become seriously ill, a good proportion also develop dysfunction in other organ systems. However, this can be the case with any serious infection.

The damage to these organs is not always caused directly by the infection, but can also result from the body's reaction to the infection.

Stomach and intestines

Some people with COVID-19 report digestive symptoms such as nausea or diarrhea, although these symptoms are less common than problems with the lungs (9).

Although coronaviruses seem to find it much easier to enter the body via the lungs, the digestive tract is not out of reach for these viruses either.

Previous reports have identified the viruses that cause SARS and MERS in intestinal biopsy samples and stool samples (11, 12).

Two recent studies report that stool samples from some people with COVID-19 have tested positive for the virus (11, 12).

However, scientists do not yet know whether transmission of COVID-19 via feces is possible.

Heart and blood vessels

COVID-19 can also attack the heart and blood vessels. This can manifest itself in symptoms such as cardiac arrhythmia, insufficient blood flow to the body tissue or very low blood pressure, which requires treatment.

So far, however, there is no evidence that the virus can directly damage the heart (14).

Liver and kidneys

When liver cells are inflamed or damaged, they can release higher than normal levels of enzymes into the bloodstream. Elevated liver enzyme levels are not always a sign of a serious problem, but these lab results have also been observed in people with SARS or MERS (15).

A recent report found signs of liver damage in a person with COVID-19 (16). However, doctors say it is not clear whether it was the virus or the drugs used to treat it that caused this damage.

Some patients hospitalized with COVID-19 also showed acute kidney damage that was so severe that in some cases a kidney transplant was necessary (17). This also occurred in SARS and MERS (18, 19).

During the SARS outbreak, scientists even found the virus that causes this disease in the kidney ducts.

However, according to the World Health Organization (WHO), there is little evidence to show that the virus directly caused kidney damage (20).

Dr. James Cherry, a professor of pediatrics at the David Geffen School of Medicine at UCLA, says the kidney damage could be due to other changes that occur during a coronavirus infection. For example, less oxygen circulates in the body when you have pneumonia and this can damage the kidneys.

Immune system

With every infection, the body's immune system reacts by attacking the foreign virus or bacteria. However, even though the immune system can rid the body of infections, it can sometimes cause collateral damage to the body.

This can take the form of an intense inflammatory response, sometimes referred to as a "cytokine storm". The immune cells produce cytokines to fight the infection, but if too many cytokines are released, this can cause problems in the body.

A lot of the damage that occurs in the body during COVID-19 disease is due to complex immune responses. The infection itself can cause an intense inflammatory response in the body, which can affect the function of multiple organ systems in the body.

Another interesting thing about the immune system is that there are currently almost no cases of COVID-19 in children under the age of 9 (21). Scientists are not sure if children cannot become infected or if their symptoms are so mild that no one notices them.

It is known that children also suffer less severe courses of other types of infections, including measles and pneumococcal disease, than adults. This could be because children have a more straightforward immune response, whereas older people can sometimes overreact. It is this excessive immune response that causes some of the damage that occurs during an infection.

There is evidence that this was the case with SARS and scientists suspect it may also be the case with COVID-19.

What you can do to avoid getting sick in the first place....

Better than any treatment or cure is of course always to avoid getting sick in the first place - which is particularly important with a disease like COVID-19, for which there is no real treatment yet.

In the case of viral diseases, the promotion of optimal immune system function should be the top priority, which is influenced by a variety of factors. Important factors for optimal immune system function include sufficient sleep, as little stress as possible and, of course, exercise. The right "dosage" is important when exercising, as training that is too extreme, which puts a lot of strain on the body and pushes its ability to regenerate to its limits, can reduce immune function for several hours after training.

Another important factor is a balanced and healthy diet that includes as much fresh fruit and vegetables as possible. In addition, there are a number of supplements that have been proven to promote and improve immune function. Here is a brief overview:

Probiotics

Intestinal flora plays an important role in immune system function. Probiotic supplements provide the body with healthy gut bacteria and studies have shown that they can reduce the risk of respiratory diseases, including COVID-19 (22, 23, 24, 25). To promote the growth of the healthy bacteria supplied, it is recommended to use a pebiotic product that serves as food for these bacteria and promotes their multiplication.

Curcumin

Curcumin, the active ingredient in turmeric, is another natural substance that can improve the function of the immune system due to its antioxidant and anti-inflammatory effects, in addition to many other positive effects on health.

Antioxidants

Antioxidants, which include vitamin C, support the function of the immune system via various mechanisms. This is also the reason why fresh fruit and vegetables, which are rich in antioxidants, strengthen the immune system and reduce susceptibility to disease.

Vitamin D

Although vitamin D is primarily associated by most people with healthier bones, it also plays an important role in optimal immune system function. Studies show that the risk of respiratory tract infections increases with a vitamin D deficiency or an insufficient supply of vitamin D, which conversely means that an optimal vitamin D supply makes you less susceptible to these diseases (28, 29).

Zinc

Zinc also plays an important role in many aspects of immune function, which means that a zinc deficiency can impair the function of the immune system. Furthermore, zinc has been shown to reduce the duration and severity of respiratory illnesses when taken at the onset (26)

Ginseng

Ginseng not only supports optimal functioning of the immune system, but can also reduce both the duration and severity of existing respiratory infections (30, 31, 32). This applies to both Panax ginseng and Siberian ginseng, which is traditionally used in Eastern European countries to prevent colds.

Vitamin C

Vitamin C is not without reason the classic supplement for supporting immune function, based in part on its antioxidant and anti-inflammatory effects. In fact, a study review that looked at over a hundred individual studies came to the conclusion that supplementation with 100 to 200 mg of the vitamin can prevent respiratory infections (27).

Garlic extracts (garlicin)

Garlic has antimicrobial and antiviral properties and can activate certain genes of the immune system, resulting in a significant improvement in the function of NK and T cells of the immune system (33, 36). Several studies have shown that garlic supplementation can both reduce the risk of respiratory disease and reduce the duration of illness (34, 35). In order to benefit from these advantages without the annoying smell of garlic, supplements that contain the active ingredient of garlic - garlicin - in concentrated form are recommended.

Green tea extract

Green tea is rich in flavonoids - in particular epigallocatechin gallate, or EGCG for short. EGCG has pronounced antioxidant effects and studies have shown that it can improve immune function. In addition, the theanine contained in green tea supports the production of germ-killing compounds in the T-cells of the immune system.

References:

  1. https://www.cdc.gov/coronavirus/2019-ncov/about/symptoms.html
  2. http://weekly.chinacdc.cn/en/article/id/e53946e2-c6c4-41e9-9a9b-fea8db1a8f51
  3. https://jamanetwork.com/journals/jama/fullarticle/2761044
  4. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30374-3/fulltext
  5. https://www.lung.org/lung-health-and-diseases/lung-disease-lookup/ards/learn-about-ards.html
  6. https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(20)30076-X/fulltext
  7. https://jamanetwork.com/journals/jama/fullarticle/2761044
  8. https://www.mayoclinic.org/diseases-conditions/ards/diagnosis-treatment/drc-20355581
  9. https://www.cdc.gov/coronavirus/2019-ncov/hcp/clinical-guidance-management-patients.html
  10. https://www.sciencedirect.com/science/article/pii/S0016508503012150
  11. https://advances.sciencemag.org/content/3/11/eaao4966
  12. https://www.nejm.org/doi/full/10.1056/NEJMoa2001191
  13. https://www.medrxiv.org/content/10.1101/2020.02.06.20020974v1
  14. https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(20)30076-X/fulltex
  15. https://annals.org/aim/fullarticle/1817260/clinical-course-outcomes-critically-ill-patients-middle-east-respiratory-syndrome
  16. https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(20)30076-X/fulltext
  17. https://jamanetwork.com/journals/jama/fullarticle/2761044
  18. https://www.kidney-international.org/article/S0085-2538(15)50506-1/fulltext
  19. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4689825/
  20. https://apps.who.int/iris/bitstream/handle/10665/207501/9290612134_eng.pdf?sequence=1&isAllowed=y
  21. http://weekly.chinacdc.cn/en/article/id/e53946e2-c6c4-41e9-9a9b-fea8db1a8f51
  22. https://www.ncbi.nlm.nih.gov/pubmed/19747410
  23. https://www.ncbi.nlm.nih.gov/pubmed/20803023
  24. https://www.ncbi.nlm.nih.gov/pubmed/23020819
  25. https://www.ncbi.nlm.nih.gov/pubmed/25927096
  26. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3273967/
  27. https://www.ncbi.nlm.nih.gov/pubmed/29099763
  28. https://pubmed.ncbi.nlm.nih.gov/28202713
  29. https://pubmed.ncbi.nlm.nih.gov/19237723
  30. https://www.ncbi.nlm.nih.gov/pubmed/19592479
  31. https://www.ncbi.nlm.nih.gov/pubmed/16247099
  32. https://pubmed.ncbi.nlm.nih.gov/16566675/
  33. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103721/
  34. https://www.ncbi.nlm.nih.gov/pubmed/11697022
  35. https://www.ncbi.nlm.nih.gov/pubmed/22280901
  36. https://www.ncbi.nlm.nih.gov/pubmed/26423732
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Can CBD oil relieve pain?
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The popularity of CBD is booming. Most people use this oil to relieve pain caused by arthritis, multiple sclerosis, migraines and irritable bowel syndrome. But are these uses supported by science? And what type of supplement provides the fastest and most effective pain relief? This article will give you answers to these questions.

What is CBD oil?

CBD oil is a therapeutic oil made from the cannabis-derived compound cannabidiol, or CBD. Unlike THC, CBD is not intoxicating.

People commonly use medical cannabis containing CBD and THC for pain relief. In two surveys of over 3,500 people using these medications, over 50% reported suffering from various types of disease-related pain. The conditions most commonly treated with CBD - and other cannabis products - include

  • Arthritis (rheumatoid arthritis and osteoarthritis)
  • multiple sclerosis
  • Headaches (migraines, cluster headaches and drug-induced headaches)
  • Lower back pain
  • Cancer pain
  • Fibromyalgia
  • Nerve pain
  • Irritable bowel syndrome pain

Hemp-derived CBD oil is legal in many countries, while marijuana-derived oil can contain higher THC levels and is therefore more strictly regulated.

CBD oil for pain relief

How does it work?

Interactions with the endocrine system

The endocannabinoid system consists of two receptors: CB1 and VB2. The cannabinoids that the body produces itself - including anandamide - bind to these receptors. CB1 receptors are primarily found in brain cells, while CB2 receptors are most abundant in immune cells.

Cannabinoids in general - including anandamide and THC - reduce pain by activating these receptors. In fact, anandamide deficiency has been linked to painful conditions such as migraines, fibromyalgia and irritable bowel syndrome (1).

CBD is less likely to bind to CB receptors, blocking them rather than activating them. However, CBD indirectly increases the amount of cannabinoids in the body: it stops the breakdown and excretion of anandamide. This probably explains why it enhances the pain-relieving effects of THC (2, 3).

However, CBD and cannabis products are not the only way to increase your cannabinoid levels. There are at least 49 other pathways that we know of.

Anti-inflammatory mechanisms

CBD oil is a powerful anti-inflammatory, which probably explains why it can prevent and relieve pain. Looking at its effects on a cellular level, we see that it affects over a dozen anti-inflammatory mechanisms and molecules. Firstly, CBD activates receptors that reduce sensitivity to inflammation (TRPV1 and TRPA1) and nerve pain (5HT1A and glycine receptors) (4, 5, 6).

It also blocks the primary pain node NF-kB, activates anti-inflammatory PPAR-gamma and prevents the degradation of anti-inflammatory adenosine. In turn, CBD reduces the production of many pro-inflammatory messengers (IL-1beta, IL-6, TNF-alpha, IFN-gamma and prostaglandins (7, 8, 9).

In addition, CBD increases the levels of the anti-inflammatory cytokines IL-4 and IL-19 (10). Last but not least, CBD enhances the analgesic effects of opioids such as morphine (11).

Next, we'll look at whether CBD oil works for a range of pain conditions.

When does CBD work?

1) Multiple sclerosis

In multiple sclerosis, pain is caused by involuntary muscle contractions and damage to nerves, muscles and joints. THC, CBD and a combination of both were similarly effective in reducing involuntary muscle contractions and pain in a small study of 24 subjects with multiple sclerosis (12).

In mice with multiple sclerosis, CBD reduced inflammation and nerve damage, which slowed the progression of the disease. Its effects may vary when CBD is combined with other hemp-derived cannabinoids. THC provides additional relief while another compound (palmitoylethanolamide) blocked the positive effects of CBD (13, 14).

However, an oral spray containing similar amounts of THC and CBD called nabiximol is commonly used for this condition.

Summary: Extracts containing THC and CBD relieve pain caused by multiple sclerosis, while there is some evidence that CBD alone may also be effective.

2) Nerve pain (neuropathy)

CBD reduced nerve pain caused by brain injury, repeated nerve stimulation, cancer drugs and diabetes in rats and mice. It activated three receptors that reduce pain sensitivity (TRPV1, 5-HT1A and glycine receptors), lowered levels of pro-inflammatory cytokines and prevented T cells from attacking the nerves (15, 16, 17). In addition, CBD enhanced the analgesic effects of THC in mice (18).

As with multiple sclerosis, clinical trials for difficult-to-treat nerve pain often successfully tested a spray containing THC and CBD.

Summary: Extracts with CBD and THC reduce difficult-to-treat nerve pain. CBD alone may also help, but clinical trials are needed to confirm this.

3) Arthritis

Arthritis refers to damage to joint cartilage caused by wear and tear (osteoarthritis) or autoimmune reactions (rheumatoid arthritis). In a survey of nearly 3,500 people who used medical cannabis, 21% reported using it to treat arthritis and often reported good results.

Although the only clinical trial conducted to date examined a spray containing THC and CBD, a follow-up study is underway to examine the effect of CBD alone on joint pain in people with rheumatoid arthritis (19).

Both orally ingested and skin-applied CBD relieved pain and inflammation in dogs and rats with osteoarthritis. It was also effective in mice and rats with rheumatoid arthritis (20, 21).

Summary: CBD in combination with THC relieves joint pain. Studies to test the pain-relieving effects of CBD alone on arthritis pain are underway.

4) Fibromyalgia

Fibromyalgia can cause widespread pain, possibly due to the brain being more sensitive to pain signals (22).

In a clinical trial, a vape containing equal amounts of THC and CBD slightly reduced fibromyalgia pain. Vapes containing more of one or the other compound, however, were found to be ineffective (23).

CBD injected directly into the muscles may be more effective in treating fibromyalgia, as it relieved pain in rats with a similar disorder (myofascial pain) (24).

5) Irritable bowel syndrome and inflammatory bowel disease

Irritable bowel syndrome and inflammatory bowel disease cause pain, cramping and diarrhea or constipation. Although both conditions are similar, inflammatory bowel disease causes more inflammation and damage to the intestinal lining.

One survey showed that almost 4% of all medical cannabis users used it to treat irritable bowel syndrome and inflammatory bowel disease, and another survey of people with inflammatory bowel disease showed that 22% treated this condition with cannabis oil.

CBD has not yet been tested in people with irritable bowel syndrome. This disease is thought to cause pain by increasing the production of TRPV1 receptors in the gut. TRPV1 triggers inflammatory pain and stimulating these receptors with CBD (or other compounds such as chili pepper or capsaicin) reduces the sensation of pain, which could explain why CBD may provide pain relief in IBS (25, 4).

Inflammation of the intestine increases the permeability of the intestinal barrier, which aggravates irritable bowel syndrome. In a clinical study of 30 healthy men, CBD reduced the permeability of the intestinal barrier and prevented pro-inflammatory cytokines from entering the cells of the intestinal mucosa (26).

Alternatively, CB1 activation by anandamide and other cannabinoids reduced inflammation of the cells of the intestinal wall. Although CBD primarily binds to other receptors, it could indirectly activate the CB1 receptors and thus reduce intestinal inflammation by increasing anandamide levels (27).

Nevertheless, CBD showed little or no effect on symptoms of irritable bowel syndrome in 2 studies involving 80 subjects (28, 29).

However, CBD was more effective in rats and mice with irritable bowel syndrome. CBD relieved inflammation and tissue damage, reduced pain and enhanced the anti-inflammatory effects of THC (30).

Summary: CBD oil could increase natural cannabinoid levels and reduce inflammation associated with IBS. However, clinical studies are still lacking.

6. back pain

In a clinical study of 11 subjects suffering from back pain despite surgery, a cannabis oil containing CBD and THC as an adjunctive therapy reduced pain and improved quality of life. However, the oil contained more THC than CBD (31).

In another study of 200 people with chronic pain, 19% of whom suffered from lower back pain, medicinal cannabis (with THC and CBD) reduced pain and opioid use (32).

Summary: Only products with CBD and THC appear to relieve back pain. There are no studies to date with CBD alone, although there are reports of successful use.

7 Headaches and migraines

Cannabis is commonly used to treat all types of headaches. In a study of 100 migraine patients using medicinal cannabis, 85% reported reduced pain and reduced migraine frequency (33).

Although activation of the CB1 receptor by THC may be responsible for most of this effect, CBD may help prevent migraine attacks by stimulating the release of serotonin, which reduces migraine pain (34).

On the other hand, CBD may also trigger migraine attacks by activating the TRPV1 receptor and releasing CGRP (a protein that dilates blood vessels in the brain) (35).

Summary: CBD alone is unlikely to reduce migraines and headaches, whereas THC is more likely to help.

8. pain after medical procedures

HPV vaccination can cause a number of adverse side effects, including severe pain, fatigue and sleep disturbances. In a small study of 12 subjects who developed these symptoms after vaccination, a CBD-enriched hemp oil helped to relieve pain and increase vitality and well-being (35).

Chronic pain is a side effect of kidney transplants, which is usually treated with painkillers that can damage the kidneys. In a small study of 7 transplant patients, CBD reduced this pain in all but one patient (36).

Injected CBD reduced post-operative pain in rats. An oral cannabis product that contained more THC than CBD also reduced postoperative pain in a clinical trial (75).

Summary: CBD appears to reduce pain after medical procedures.

9 Other types of pain

Some case studies report successful pain relief with CBD (often in combination with THC) in people with

  • Endometriosis
  • Benign tumors in the nerves
  • Two types of rare inflammatory diseases of the skin (epidermolysis bullosa and pyoderma gangrenosum)

Limitations

Many of the human studies used CBD in combination with varying amounts of THC. However, animal studies suggest that CBD alone can also relieve pain.

CBD oil dosages for pain relief

The only clinical trial of CBD for pain relief after kidney transplantation used quite high dosages: starting with 100 mg per day and increasing the dosage to 300 mg per day over 3 weeks (38).

  • Unofficial doses are lower and are based on recommendations from manufacturers and users. The optimal dosage depends on the following factors:
  • Body weight: heavier people require a higher dosage to experience pain relief.
  • Type of pain: severe and chronic pain usually requires higher dosages than mild pain.
  • Habituation: people who use CBD regularly may develop a habituation effect over time, requiring higher dosages. With this information in mind, the recommended CBD dosages (taken one to three times a day) are as follows:
  • Light people (under 60 kilos): 10 to 17 mg
  • Medium people (60 kilos to 90 kilos): 15 to 25 mg
  • Heavy people (over 90 kilos): 22 to 45 mg

Start with the lowest dosage and observe your reaction. If you tolerate CBD oil well, you can gradually increase the dose until you achieve the desired effect.

How to take it

CBD oil is available in different dosage forms:

  • Oil tinctures
  • Capsules and tablets
  • teas
  • Oral sprays
  • Liquids for e-cigarettes
  • Lotions, ointments and creams for application to the skin
  • plasters

The choice of dosage form may depend on the type of pain:

  • Capsules and teas release CBD more slowly, but their effects also last longer. These dosage forms are well suited for chronic pain.
  • Liquids for e-cigarettes, mouth sprays and oil tinctures are absorbed more quickly and are therefore well suited for acute pain.
  • Dosage forms applied to the skin are mainly used for muscle and joint pain.

How long does it take for the effect to kick in?

The length of time it takes for you to feel pain-relieving effects depends on the method of delivery, which determines the rate at which CBD is released into your bloodstream (39, 40):

  • Liquid for e-cigarettes: 5-15 min
  • Oral sprays and oral tinctures that are absorbed through the mucous membranes: 15-30 min
  • Oral capsules and teas: 30-180 min
  • Forms applied to the skin: 30-120 min

Testimonials

Most people use CBD oil for painful conditions such as multiple sclerosis, arthritis, nerve pain, fibromyalgia, irritable bowel syndrome and back pain. Users are usually satisfied and most of them report pain relief.

In some cases, users have complained that the oil did not work for them. Depending on the type of product and the method of administration, some users have also complained about the bad taste.

Possible side effects of CBD oil:

CBD oil is generally well tolerated and has few, usually mild, side effects. The most common side effects reported by people using CBD for pain relief included (41):

  • Dry mouth
  • euphoria
  • hunger
  • dizziness
  • Drowsiness and fatigue
  • Nausea

Conclusion:

CBD oil can cause pain by increasing anandamide levels - the human body's natural cannabinoid molecule. Unlike THC, it does not act directly via the cannabinoid receptors and has no intoxicating effect.

CBD oil can help with mild multiple sclerosis pain, nerve pain, arthritis and irritable bowel syndrome. Its side effects are mild and most people tolerate CBD oil well.

If you need quick pain relief, use a liquid for e-cigarettes. For longer-lasting pain relief, capsules are better. For localized pain such as back pain or knee pain, you may benefit from creams or other CBD formulas to apply to the skin.

References:

1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2219532/
2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189767/
3. https://www.ncbi.nlm.nih.gov/pubmed/8874830
4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1573017/
5. https://www.ncbi.nlm.nih.gov/pubmed/18354058/
6. https://www.ncbi.nlm.nih.gov/pubmed/29407767
7. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2804319/
8. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC16904/
9. https://www.ncbi.nlm.nih.gov/pubmed/14963641
10. https://www.ncbi.nlm.nih.gov/pubmed/27215129/
11. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142691/
12. https://www.ncbi.nlm.nih.gov/pubmed/12617376
13. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165959/
14. https://www.ncbi.nlm.nih.gov/pubmed/25637488
15. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447028/
16. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6476923/
17. https://www.ncbi.nlm.nih.gov/pubmed/30898678
18. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554313/
19. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561449/
20. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6065210/
21. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5690292/
22. https://www.ncbi.nlm.nih.gov/pubmed/24737367
23. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430597/
24. https://www.ncbi.nlm.nih.gov/pubmed/31158702
25. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2564830/
26. https://www.ncbi.nlm.nih.gov/pubmed/31054246
27. https://www.ncbi.nlm.nih.gov/pubmed/28404744
28. https://www.ncbi.nlm.nih.gov/pubmed/28349233
29. https://www.ncbi.nlm.nih.gov/pubmed/29538683
30. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047908/
31. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134407/
32. https://www.ncbi.nlm.nih.gov/pubmed/26889611
33. https://www.ncbi.nlm.nih.gov/pubmed/26749285
34. https://www.ncbi.nlm.nih.gov/pubmed/28025094
35. https://www.ncbi.nlm.nih.gov/pubmed/28457055
36. https://www.ncbi.nlm.nih.gov/pubmed/29579828
37. https://www.ncbi.nlm.nih.gov/pubmed/16645457
38. https://www.ncbi.nlm.nih.gov/pubmed/29579828
39. https://www.ncbi.nlm.nih.gov/pubmed/29307505
40. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275223/
41. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043845/

Source: https://selfhacked.com/blog/can-cbd-oil-relieve-pain/

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13 simple ways to lower your triglyceride levels
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Triglycerides are a type of fat that is found in your blood. After you eat, your body converts the calories you don't need into triglycerides and stores them in your fat cells for later use.

Even though you need triglycerides to provide your body with energy, too many triglycerides in your blood can increase the risk of heart disease.

About 25% of all people in the Western world have elevated triglyceride levels above 200 mg/dL (2.26 mmol/L). Obesity, uncontrolled diabetes, regular alcohol consumption and a high-calorie diet can all contribute to high blood triglyceride levels.

This article shows you 13 ways to lower your blood triglyceride levels naturally.

1. lose some weight

Whenever you eat more calories than you need, your body converts the excess calories into triglycerides and stores them in fat cells. For this reason, losing weight is an effective way to lower your blood triglyceride levels. Scientific research has shown that losing just 5 to 10% of your body weight can lower your blood triglyceride levels by up to 40 mg/dL (0.45 mmol/L) (1).

Although long-term sustained weight loss should be the goal, studies have found that weight loss can have a lasting effect on blood triglyceride levels even if you gain back some of the lost weight. One study focused on subjects who had dropped out of a weight management program. Although they had regained some of the weight they had lost, their blood triglyceride levels remained 24 to 26% lower than before the weight loss (2).

2 Limit your sugar intake

Added sugar is one of the main problems in many people's diets. The American Heart Association recommends consuming no more than 6 to 9 tablespoons of added sugar per day, but the average consumption is just under 20 teaspoons. Hidden sugar is found in sweets, soft drinks and fruit juices.

Excess sugar in the diet is converted into triglycerides, which can increase blood triglyceride levels along with other risk factors for heart disease.

A 15-year-old study showed that those who consumed at least 25% of their calories in the form of sugar had twice the risk of dying from a heart attack compared to those who consumed less than 10% of their calories in the form of sugar (3).

Another study found that consumption of added sugar in children led to higher blood triglyceride levels (4).

Fortunately, several studies have shown that diets low in carbohydrates and added sugars can lead to lower blood triglyceride levels (5, 6). Even replacing sugar-sweetened beverages with water could lower blood triglyceride levels by almost 29 mg/dL (0.33 mmol/L) (7).

3. follow a low-carb diet

Similar to added sugars, added carbohydrates can also be converted into triglycerides and stored in fat cells. It is therefore not surprising that low-carbohydrate diets are associated with lower blood triglyceride levels.

A 2006 study looked at how different amounts of carbohydrates can affect triglyceride levels. Those who ate a low-carbohydrate diet and consumed about 26% of their calories in the form of carbohydrates showed a greater drop in blood triglyceride levels than those who ate a higher-carbohydrate diet and consumed up to 54% of their calories in the form of carbohydrates (6).

Another study looked at the effects of a low-carbohydrate and a high-carbohydrate diet over the course of a year. The low-carbohydrate diet group not only lost more weight, but also experienced a greater reduction in blood triglyceride levels (5).

Finally, a study from the same year compared low-fat and low-carbohydrate diets. After 6 months, the researchers found that triglyceride levels had fallen by 38 mg/dL (0.43 mmol/L) in the low-carbohydrate group, while the low-fat group only saw a reduction of 7 mg/dL (0.08 mmol/L) (8).

4 Eat more fiber

Fiber is found in fruits, vegetables and whole grains. Other good sources include nuts and legumes. Incorporating more fiber into your diet can reduce the absorption of fat in the small intestine, which helps lower the amount of triglycerides in the blood (9).

In one study, researchers showed that supplementing with rice bran lowered blood triglycerides by 7 to 8% in diabetics (10).

Another study looked at how high-fiber and low-fiber diets affect blood triglyceride levels. The low-fiber diet increased triglyceride levels by 45% within 6 days, but during the high-fiber phase, triglyceride levels dropped below baseline (11).

5 Exercise regularly

Good HDL cholesterol is inversely related to triglyceride levels, which means that high HDL cholesterol levels can help lower triglyceride levels. Aerobic exercise can increase HDL cholesterol levels in the blood, which can then lower triglyceride levels. Studies show that aerobic exercise combined with weight loss is particularly effective in lowering triglyceride levels (12). Examples of aerobic exercise include walking, jogging, cycling and swimming.

As for the amount of aerobic exercise, health experts recommend at least 30 minutes 5 days a week.

The benefits of exercise on triglyceride levels are most evident in long-term exercise programs. One study showed that 2 hours of jogging per week over a 4-month period led to a significant reduction in blood triglyceride levels (13).

Other studies have found that higher intensity exercise over a shorter period of time is more effective than longer moderate intensity exercise (14).

6 Avoid trans fats

Artificial trans fats are the type of fat that is added to processed foods to extend their shelf life. Trans fats are commonly found in fried and baked foods made with partially hydrogenated fats.

Due to their pro-inflammatory properties, trans fats have been linked to many health problems including elevated LDL cholesterol levels and heart disease. The consumption of trans fats can also increase blood triglyceride levels.

One study showed that triglyceride levels were significantly higher when subjects followed a diet high or moderate in trans fats compared to a diet rich in unsaturated oleic acid (15).

Another study came to similar conclusions. Following a three-week diet rich in trans fats resulted in higher triglyceride levels than a diet rich in unsaturated fats (16).

7 Eat oily fish twice a week

Fatty fish is known for its heart health benefits and its ability to lower blood triglyceride levels. This is largely due to its high content of omega-3 fatty acids - a type of polyunsaturated fatty acid that is considered essential, meaning it must be consumed in the diet.

The American Heart Association guidelines recommend two portions of oily fish per week. According to studies, this can reduce the risk of heart disease by up to 36% (17).

One study also showed that eating salmon twice a week can significantly reduce blood triglyceride levels (18).

Salmon, herring, sardines, tuna and mackerel are some types of fish that are particularly rich in omega-3 fatty acids.

8. increase your consumption of unsaturated fats

Studies show that monounsaturated and polyunsaturated fats can lower blood triglyceride levels, especially when they replace other types of fat in the diet. Monounsaturated fats are found in foods such as olive oil, avocados and nuts. Polyunsaturated fats are found in vegetable oils and oily fish.

One study analyzed what 452 adults had eaten over the previous 24 hours, focusing on different types of saturated and polyunsaturated fats. The researchers found that consumption of saturated fats was associated with increased triglyceride levels, while consumption of polyunsaturated fats was associated with lower blood triglyceride levels (19).

In another study, elderly subjects were given 4 tablespoons of extra virgin olive oil per day for 6 weeks. For the duration of the study, this was the only source of added fat in the diet. The results showed a significant decrease in triglyceride levels and LDL cholesterol levels compared to the control group (20).

To maximize the triglyceride-lowering benefits of polyunsaturated fats, you should choose a healthy fat like olive oil and use it to replace other types of fats like trans fats or highly processed vegetable oils in your diet (16).

9. stick to a regular meal pattern

Insulin resistance is another factor that can cause high blood triglyceride levels. After you eat a meal, the cells in your pancreas receive a signal to release insulin into the bloodstream. Insulin is responsible for transporting glucose into your cells for energy.

If you have too much insulin in your blood, you can become resistant to insulin, which makes it more difficult to use insulin effectively. This can lead to a buildup of both glucose and triglycerides in the blood.

Fortunately, following a regular meal pattern can prevent insulin resistance and high triglyceride levels in the blood. A growing body of research shows that irregular meal patterns can lead to reduced insulin sensitivity and an increase in risk factors for heart disease such as high LDL and total cholesterol levels (21, 22).

However, study results are mixed when it comes to meal frequency. A 2013 study showed that eating 3 meals a day significantly lowered triglyceride levels compared to eating 6 meals a day (23). In contrast, another study showed that eating 6 meals a day led to a greater increase in insulin sensitivity than eating 3 meals a day (24).

Regardless of how many meals you eat per day, eating regular meals can improve your insulin sensitivity and lower your blood triglyceride levels.

10. limit your alcohol consumption

Alcohol is high in calories and very often also high in sugar. If these calories are left unused, they can be converted into triglycerides and stored in fat cells. Although a variety of factors come into play here, some studies show that moderate alcohol consumption can increase triglyceride levels by up to 53% even when triglyceride levels were normal to begin with (25).

However, other studies have linked light to moderate alcohol consumption with a reduced risk of heart disease, while high alcohol consumption increased this risk (26, 27).

11 Add soy protein to your diet

Soy is rich in isoflavones - plant components with numerous health benefits. The latter is especially true when it comes to lowering cholesterol levels (28, 29).

Soy protein in particular has been shown to lower blood triglycerides. A 2004 study compared how soy protein and animal proteins affected triglyceride levels. After 6 weeks, it was observed that soy protein lowered triglyceride levels by 12.4% more than animal protein (30).

An analysis of 23 studies also concluded that soy protein was associated with a 7.3% reduction in triglyceride levels (31).

Soy protein is found in foods such as soybeans, tofu, edamame and soy milk.

12. eat more nuts

Nuts provide a concentrated dose of fiber, omega-3 fatty acids and unsaturated fatty acids, all of which work together to lower blood triglyceride levels.

An analysis of 61 studies showed that each serving of nuts lowered triglyceride levels by 2.2 mg/dL (0.02 mmol/L) (32). Another study of 2226 subjects came to similar conclusions, showing that nut consumption was associated with a small reduction in blood triglyceride levels (33).

Nuts attributed with these benefits include:

  • Almonds
  • pecans
  • walnuts
  • cashews
  • pistachios
  • Macadamia nuts
  • Brazil nuts

However, keep in mind that nuts are high in calories. One serving of almonds, or 23 almonds, provides 163 kcal, which means moderation is key.

Most studies have observed the greatest health benefits in people who consumed 3 to 7 servings of nuts per week (34, 35).

13. use a natural supplement

A number of supplements may have the potential to lower blood triglyceride levels. The following list contains the most important supplements that have been scientifically studied:

  • Fish oil: fish oil is known for its powerful positive effects on heart health, and one study also showed that fish oil supplements lowered triglyceride levels by 48% (36).
  • Fenugreek: Although traditionally used for other purposes, fenugreek has been shown to be effective in lowering blood triglyceride levels (37).
  • Garlic extract: Several studies conducted on animals have shown that garlic extract can lower triglyceride levels thanks to its anti-inflammatory properties (38).
  • Guggul: This herbal supplement has shown promise in lowering triglyceride levels when used in dietary therapy for patients with high cholesterol levels (39).
  • Curcumin: A 2012 study found that supplementation with low doses of curcumin can lead to a significant drop in blood triglyceride levels (40).

Conclusion

Diet and lifestyle factors have a major impact on your cholesterol levels. Choosing healthy, unsaturated fats instead of trans fats, reducing your carbohydrate intake and exercising regularly can help lower your blood triglyceride levels quickly.

With a few simple lifestyle changes, you can lower your triglyceride levels and improve your overall health at the same time.

References:

  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3120182/
  2. https://www.ncbi.nlm.nih.gov/pubmed/7712338
  3. https://www.ncbi.nlm.nih.gov/pubmed/24493081
  4. https://www.ncbi.nlm.nih.gov/pubmed/24717340
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  35. https://www.ncbi.nlm.nih.gov/pubmed/2425637
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Source: https://www.healthline.com/nutrition/13-ways-to-lower-triglycerides

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