Reduced price! GN Saw Palmetto 600mg

Saw Palmetto - GN Laboratories

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GN Saw Palmetto 600mg - Ameliorates the negative side effects of high DHT (dihydrotestosterone), estrogen and progesterone levels – equally suited for using and non-using athletes!

: GN Laboratories

: 8026

: 120 Capsules

: Prostate Support

91 G-Points
  • 24,90 €

    17,91 €

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    Ameliorates the negative side effects of high DHT (dihydrotestosterone), estrogen and progesterone levels – equally suited for using and non-using athletes!

     

    Product highlights:

    • 600mg Saw Palmetto extract per cap
    • Reduces the conversion of testosterone to DHT
    • Increases the amount of testosterone in the blood
    • Ameliorates androgen-related alopecia in men
    • Helps with oily skin and acne
    • Promotes prostate health and alleviates the symptoms of benign prostate hyperplasia
    • Minimizes potential estrogenic side effects of anabolic steroids and prohormones
    • Acts directly on the 5-alpha-reductase enzyme that is responsible for the conversion of testosterone to estrogen
    • Reduces the sensitivity to estrogen and progesterone directly at the receptor level

     

    GN Laboratories’ Saw Palmetto Extract is a totally natural and non-hazardous dietary supplement. Contrary to common believe, its usefulness is not restricted to users of anabolic steroids and prohomones, but can be used by anyone who suffers from increased levels of serum DHT.
    Oily skin, acne, androgen-related allopecia or benign prostate hyperplasia? If you suffer from any, or all of these conditions or simply want to make sure to avoid them in the future, GN Laboratories‘ Saw Palmetto Extract can help.
    In fact, Saw Palmetto can do even more: It can increase your testosterone levels and thus promote skeletal muscle hypertrophy. In combination with its ability to keep estrogen and progesterone levels at bay, this will allow for lean mass gains without water retention or fat gain, a bloated look, elevated blood pressure or even gynecomastia (aka “bitch tits”). And above all, it works equally well for using and non-using athletes, i.e. irrespective if your estrogen and progesterone levels got out of whack due to the influence of exogenous or endogenous steroids.
    Many naturopaths use Saw Palmetto as a libido enhancer with their clients. Pertinent studies may be rare, but the sheer number of users who swear by the extract of the fruits of Serenoa repens speaks for itself. Sounds interesting? Well, there is more, just keep on reading and learn what GN Laboratories’ high potency Saw Palmetto Extract can do for you.

     

    What is Saw Palmetto Extract

    Saw Palmetto is extracted from the fruit of Serenoa repens, a small plant from the palm family that is native to Florida and climatically similar regions. Serenoa repens has large leaves and carries dark red fruits that have about half the size of an olive. They are the raw material the product is made of.
    Saw Palmetto extracts are particularly rich in phytosterols. These fatty acids are pretty rare and occur only in certain types of fruits. They are the actual active ingredients of GN Laboratories’ Saw Palmetto Extract and the reason why respective extracts have been used for medical purposes ever since Mayan times.
    The Maya used Saw Palmetto as a tonic and the Seminoles appreciated its mucolytic and antiseptic effects. The native Americans also used the extract to tread gonadal atrophy, impotence, inflammatory prostate conditions, loss of libido, stunted growth of the female breast, lactation problems, menstrual disturbances, to stimulate metabolism and increase appetite.
    For over 200 years, saw Palmetto has also been one of the staple supplements in modern alternative medicine. Many of these traditional uses have meanwhile been extensively researched and the corresponding beneficial effects have been linked directly to the effects the extracts have on the human endocrine system (hormonal control).
    Both, the treatment of benign prostate hyperplasia, as well as the treatment of androgen-related alopecia, for example, belong to these canonical areas of application; and as far as the former, i.e. the treatment of benign prostate hyperplasia is concerned, Saw Palmetto extract is by far the herbal medicine with the most popular remedy with scientific evidence to back up it’s efficacy and safety (1,2).

     

    How exactly does GN Laboratories’ Saw Palmetto Extract Work?

    The primary mechanism behind the previously cited health benefits is Saw Palmetto’s well-established ability to block the conversion of testosterone to DHT by an enzyme called 5-alpha reductase (5, 6, 7, 9). What is particularly interesting about Saw Palmetto compared to other 5-ar inhibitors, is the fact that our Saw Palmetto Extract will inhibit both isoforms of this enzyme – Type I and Type II. This is something even pharmacological 5-alpha reductase inhibitors such as Finasterid (the active ingredient in medications such as Proscar and Propecia) is not capable of.
    The 5-alpha reductase enzyme will attach to the testosterone molecules in your body and catalyze their conversion to DHT. Compared to testosterone, dihydrotestosterone (DHT) has a 3x-5x higher androgen activity. DHT is thus responsible for the majority of the potentially detrimental effects of androgens on your body. Hereditary androgen-related alopecia, prostate hyperplasia, oily skin and acne, are probably the most common of these side effects.
    Users of anabolic steroids will be familiar with these side effects. However, the very same effects can also occur in individuals who do not abuse exogenous steroids. If you are genetically susceptible to its effects, even minor increases in DHT will have negative impacts on the physiology of your sebaceous glands, the hair follicles on your scalp, or the prostate.
    By directly inhibiting the enzymatic conversion of testosterone to DHT, GN Laboratories’ Saw Palmetto Extract can reduce if not completely abolish any unwanted side effects of high DHT. Interestingly, its effects are not restricted to testosterone, only. Saw Palmetto will rather inhibit the conversion of all anabolic steroids that can be converted to DHT.
    Its ability to reduce the binding affinity of DHT to its receptors, adds another layer to the androgen protective effects of GN Laboratories’ Saw Palmetto Extract. This is particularly interesting for people who use performance enhancing agents that may not be converted to DHT, but do actually have a pretty high affinity to directly bind to the androgen receptor. In these cases, a classic 5-alpha reductase inhibitor such as Finasterid or Dutasterid would not be useful, because the effect Saw Palmetto exerts on the binding capacity of the androgen receptors is not directly related to the inhibition of the enzymatic reaction and thus not present with Proscar, Propecia & Co.
    A common question we get is whether it is not possible that the reduced androgen activity would lead to a reduction in skeletal muscle anabolism. In view of the fact that testosterone does work its anabolic magic by interacting with the androgen receptors this is unquestionably a reasonable concern. With DHT being 3-5x more androgenic it would after all stand to reason that it was a 3-5x more potent muscle builder, as well. In practice, it is however the exact other way around.
    The reason why DHT is not as good of a muscle builder is testosterone is the presence of another enzyme that goes by the cryptic name 3-alpha-hydroxysteroid dehydrogenase in the muscle tissue. This enzyme will facilitate the immediate conversion of DHT to one out of several hormonally inactive metabolites. Since the latter cannot bind to and activate the androgen receptors, they are also unable to promote lean mass gains.
    The decreased conversion of testosterone to DHT in response to the consumption of GN Laboratories’ Saw Palmetto Extract, on the other hand, will increase the levels of testosterone at the expense of DHT and will thus effectively boost skeletal muscle anabolism.
    Next to its effects on 5-alpha reductase and DHT, GN Laboratories‘ Saw Palmetto Extract has a couple of additional interesting properties. In clinical trials, scientists observed that Saw Palmetto will also block the progesterone and estrogen receptors. In that it works like a SERM - a selective estrogen receptor modulator such as Tamoxifen (Nolvadex) or Clomifen (Chlomid). While these drugs have originally been developed to treat breast cancer, both are used by steroid users to ameliorate estrogen related side effects. In that, the mechanism of action is actually pretty straight forward: GN Laboratories’ Saw Palmetto extract will simply bind to the estrogen or progesterone receptor, but instead of activating it, it blocks other molecules, namely estrogen and progesterone from binding.
    Its SERM-like effects make GN Laboratories’ the perfect choice for using and non-using athletes to minimize their risk of developing estrogen related side effects such as the growth of male breast tissue (gynecomastia), water retention that will make your muscle look soft, blood pressure issues and an increase in body fat. Even more so than for DHT, side effects of high estrogen levels can occur even if you are not (ab-)using performance enhancing drugs. Pubertal gynecomastia, for example, is one of the most common, yet often transient side effects of naturally high estrogen levels.
    Selective estrogen receptor modulators are also used after the cessation of an androgen or prohormone cycle. In these situations they will promote the re-establishment of normal natural testosterone levels by inhibiting the negative feedback estrogen exerts on the luteinizing hormone production in the brain and the corresponding reduction in testicular teststosterone production.
    In this context, it is however important to note that GN Laboratories’ Saw Palmetto extract will – just like any other synthetic 5-alpha reductase inhibitor, not work from one day to the next. It will take 2-3 months of continuous usage before the side effects of previously elevated DHT levels are going to disappear – and that despite the fact that the effects on the alpha-reductase levels are immediate. Against that background it would be counterproductive to stop taking the product after only four weeks simply because your hair isn’t regrowing yet and your skin still looks oily. You know the good old saying “Haste Makes Waste”, don’t you?

     

    Who is going to benefit from GN Laboratories’ Saw Palmetto Extract

    Despite the fact that anabolic steroid users are supposedly the group that will see the greatest benefits, Saw Palmetto can be used by anyone suffering from androgen-related health issues ranging from Acne, to the loss of scalp, benign prostate hyperplasia and related problems from high estrogen and/or progesterone levels (gynecomastia, high blood pressure, water retention, increased body fat).
    GN Laboratories’ Saw Palmetto can also be used during post-cycle therapy to block the estrogenic negative feedback and restore a normal testisticular testosterone production. .
    Even people with a genetic precipitation for alopecia and / or severe acne can benefit, as long as these symptoms are brought about by an overproduction of or increased sensitivity to DHT.
    In view of the association between age and the occurrence of benign prostate hyperplasia, every man in his early forties (or older) will benefit from the ingestion of Saw Palmetto. In this regard it’s also worth mentioning that GN Laboratories’ Saw Palmetto extract does not mess with the PSA (prostate specific antigen) values your Dr. will use as a diagnostic tool to assess your risk of developing prostate cancer.

     

    The GN Laboratories Quality Guarantee

    We use only the purest, highest grade ingredients the market has to offer. To ensure the constant quality of all our products, we conduct regular laboratory tests to ensure the purity and quality of all ingredients.

     

    Warnings:

    Since GN Laboratories’ Saw Palmetto Extract exerts both direct, as well as indirect effects on the endocrine system, it must not be used by pregnant and nursing women. GN Laboratories’ Saw Palmetto decreases clotting times. Supplementation with Saw Palmetto must therefore be seized at least 2 weeks before surgery. It is of paramount importance to discuss the usage and potential interactions with other medications - esp. anti-coagulants, but also common medications such as Aspirin, Diclofenac, Ibuprofen and Naproxen - with your medical practitioner before you start using the product. Since GN Laboratories Saw Palmetto Extract may reduce the effects of estrogen and progesterone in your body, it will hamper the effect of hormonal contraceptives and estrogen preparations that are prescribed to ameliorate the symptoms of menopause. Women who use oral contraceptives are thus strongly advised to resort to alternative means of contraception, whenever they are using GN Laboratories’ Saw Palmetto extract.

     

    References

    1. Markowitz JS, Donovan JL, Devane CL, et al. (December 2003). "Multiple doses of saw palmetto (Serenoa repens) did not alter cytochrome P450 2D6 and 3A4 activity in normal volunteers". Clin. Pharmacol. Ther. 74 (6): 536–42.
    2. Wilt T, Ishani A, Mac Donald R (2002). "Serenoa repens for benign prostatic hyperplasia". In Tacklind, James. Cochrane Database Syst Rev (3)
    3. Wadsworth TL, Worstell TR, Greenberg NM, Roselli CE (May 2007). "Effects of dietary saw palmetto on the prostate of transgenic adenocarcinoma of the mouse prostate model (TRAMP)". The Prostate 67 (6): 661–73.
    4. Scholtysek C, Krukiewicz AA, Alonso JL, Sharma KP, Sharma PC, Goldmann WH (February 2009). "Characterizing components of the Saw Palmetto Berry Extract (SPBE) on prostate cancer cell growth and traction". Biochemical and Biophysical Research Communications 379 (3): 795–8.
    5. Anderson ML (2005). "A preliminary investigation of the enzymatic inhibition of 5alpha-reduction and growth of prostatic carcinoma cell line LNCap-FGC by natural astaxanthin and Saw Palmetto lipid extract in vitro". Journal of Herbal Pharmacotherapy 5 (1): 17–26
    6. Habib FK, Ross M, Ho CK, et al. Serenoa repens (Permixon) inhibits the 5alpha-reductase activity of human prostate cancer cell lines without interfering with PSA expression. Int J Cancer 2005;114:190-4.
    7. Scaglione F, Lucini V, Pannacci M, Caronno A, Leone C (2008). "Comparison of the potency of different brands of Serenoa repens extract on 5alpha-reductase types I and II in prostatic co-cultured epithelial and fibroblast cells". Pharmacology 82 (4): 270–5
    8. Abe M, Ito Y, Oyunzul L, Oki-Fujino T, Yamada S (April 2009). "Pharmacologically relevant receptor binding characteristics and 5alpha-reductase inhibitory activity of free Fatty acids contained in saw palmetto extract". Biological & Pharmaceutical Bulletin 32 (4): 646–50.

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