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Cissus Xplode - GN Laboratories

29,90 €

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/ Content: 160 Capsules
0.3 kg
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  • Content: 160 Capsules
  • Form : Capsules

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GN Cissus Xplode Support optimal joint, cartilage, tendon and bone health and repair!

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29,90 €

per Kapsel
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0.3 kg
Lieferzeit 1-2 Werktage
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GN Laboratories Cissus Xplode Support optimal joint, cartilage, tendon and bone health and repair!


Increases fatty acid oxidation and overall well-being, and amplifies skeletal muscle hypertrophy. You can hardly ask for more!

Product highlights:


  • Promotes the regeneration of joints, cartilage, tendons and bone
  • Protects tendon, cartilage and joints during intense workouts
  • Has significant analgesic effects (natural pain killer)
  • Is able to induce significant reductions of the catabolic hormone cortisol
  • Promotes a positive nitrogen balance (increase protein retention = greater muscle gains)
  • Is a potent anti-catabolic agent
  • Accelerates fat loss significantly
  • Protects lean muscle mass on a diet
  • Has positive effects on blood lipids and cholesterol levels
  • Contains powerful antioxidants
  • Uses with the most concentrated Cissus extract currently available
  • 100% natural and safe

GN Laboratories Cissus Xplode is a true innovation. It uses the most potent Cissus Quadrangularis extract your money can buy. It is standardized to contain the maximal amount of the active ingredients. Currently, there is no other Cissus Quadrangularis extract we know of that comes remotely close to the total amount of bioactive substance you get from a single serving of Cissus Xplode.
Cissus is a completely natural and absolutely safe ingredient which is, for a good reason, one of the rising stars on the supplement stage.
Cissus is probably best known for its beneficial effects on tendons, joints, cartilage and bone. It is thus not surprising that countless of Athletes all around the world are taking Cissus Quadrangularis extracts to support the healing process, when they are injured. In fact, there is currently no other natural supplement on the market that does reliably support the regeneration process of joints, bone, cartilage and tendons, and ease the corresponding pain, at the same time.
Still, Cissus Quadrangularis is also worth considering for athletes and gymrats who are less concerned about their joint and cartilage health. What many people don’t know, is that Cissus is also one of the few true body recompositioning agents that has been shown to promote both, gains in lean mass and reductions in body fat at the same time. It can also be used to maintain a maximal amount of muscle mass during a diet by promoting the oxidation of body fat and protecting muscle protein from being abused as a fuel source.
And, quasi as a highly desirable side effect, Cissus will also improve your blood lipids and other health relevant serum markers (8, 9, 10).
Cissus extracts owe their muscle building prowess to a whole host of synergistic mechanism. They act as anti-catabolic agent, promote the blood flow to the musculature and speed up the necessary adaptation process your tendons, joints and bone will undergo, whenever you are increasing your training weights.
I know, this sounds almost too good to be true and there is in fact a string attached. All these statements are valid only if you are using a high quality extract and those are difficult to find and – needless to say – pretty expensive. Thriving for maximal profits, instead of customer satisfaction, most supplement companies do thus resort to the cheapest resources the market has to offer… don’t waste your money for any of these products with ingredients from questionable sources. With Cissus Xplode from GN Laboratories you can get what we believe is the most potent and pure Cissus Quadrangularis extract that’s currently available for a very reasonable price.
It does not matter whether you are suffering from injuries or chronic pain in your tendons, cartilage, joints and bone, if you want to speed up your fat loss and maintain muscle mass on a diet or simply want to make sure to get the most out of your workouts. Cissus Xplode IS going to help you achieve your goals.

What exactly is Cissus Quadrangularis?

Cissus Quadrangularis, the active ingredient in GN Laboratories groundbreaking Cissus Xplode, is derived from a perennial plant of the grape family. It grows naturally in India, Africa and Sri Lanka. Cissus has been used as part of Siddah, i.e. the Indian traditional medicine, for centuries. Usually it is used as a tonic, analgesic and remedy for all sorts of musculoskeletal injuries and ailments. The active ingredients in Cissus Quadrangularis are mostly ketosterones, such as 3-ketosteron, flavonoids, phyosterols, beta-sitosteron, tipenoides, tannins and single compounds such as quercitin, ascorbic acid, carotene and calcium oxalate (1,2,7), all of which occur naturally and in comparably high concentrations in the plant.

GN Laboratories Cissus Xplode supports the health and regeneration of tendons, ligaments, joints, cartilage and bone

As countless athletes all around the world will confirm, there is hardly anything that will hamper your training progress to a similar degree as injuries or chronic pain in your tendons, ligaments and joints. Way too often these athletes will resort to artificial pain killers such as Ibuprofen or Diclofenac, in order to “train through the pain”. Depite being common practice, this strategy has a at least two severe downsides: Firstly, pain killer treat only the symptoms, yet not the cause of the pain – in other words, the injury won’t heal any faster and you are even running the risk of making things worse. And secondly, many of the non-steroidal pain killers have been found to hamper the accrual of lean mass.
Don’t make the same mistake. Throw away your NSAIDs you are taking and switch over to GN Laboratories Cissus Xplode. Contrary to the regular pain killers, Cissus Xplode will not simply numb the symptoms. Cissus Xplode will work by taking care of the root cause of the problem. It will accelerate the healing process and help your body to rebuild cartilage, tendons, joints and bone, while simultaneously reducing the injury related pain. A whole host of studies was able to prove that the active ingredients in Cissus Quadrangularis extracts are so potent that they will even boost the tedious bone healing process (14, 15, 16, 17, 18, 19).
Much contrary to regular pain killers, Cissus Xplode will not hamper lean muscle gains – in fact, quite the contrary is the case. By targeting synergistic anabolic processes, we are going to discuss in detail later, Cissus Xplode will acutally promote the accrual of lean mass and promote a positive nitrogen balance and thus increase the net protein retention in your muscles.
The mere fact that Cissus Xplode is going to help your tendons recover from an injury does yet not restrict its usefulness to athletes who have already received an injury. On the contrary, it is at least as useful for athletes who want to prevent getting injured in the first place. GN Laboratories Cissus Xplode will do that by strengthening your tendons, ligaments, cartilage and bone and ensuring optimal post-workout recovery. This is of utmost importance especially for those athletes who are using performance enhancing products that will yield incredible fast strength and muscle gains. In fact, the gains are coming so rapidly that your tendons, ligaments, joint, cartilage and bone can hardly keep pace with the ever increasing loads, so that the risk of injury increases with every new personal best you are setting. GN Laboratories Cissus Xplode can reduce this risk significantly by supporting the natural adaptation process of your ligaments, tendons, joints, cartilage and bone that is necessary to increase their resilience and ability to cope with the ever-increasing training loads.

GN Laboratories’ Cissus Xplode actively supports your fat loss efforts

A whole host of interesting studies (8, 9, 10) were able to prove that highly standardized Cissus Quadrangularis Extracts, like the one we use in Cissus Xplode, will exert highly beneficial and clearly noticeable fat loss effects, while simultaneously improving all of the import markers of lipid metabolism. In one of these studies (9) the subjects received either two servings of 150mg Cissus Quadrangularis extract or placebo for 10 weeks. The study outcome was astonishing: The participants, who had been specifically advised to adhere to their regular diet for the duration of the study lost a highly significant amount of body fat.
The subjects in the Cissus group lost on average 8.73kg, which is equivalent to 8.82% of their initial body weight. The volunteers who had been randomized to the placebo group, on the other hand showed only a non-significant weight reduction of 2.06kg. Now, remember: These 4x higher weight loss in the Cissus group was achieved in the absence of any dietary changes and/or caloric reduction! And what’s even more important, the same outstanding difference was observed for the body fat levels as well. With 3.97%, the subjects in the placebo trial lost significantly less body fat than their peers who consumed the Cissus Quadrangularis extract who got rid of 14.63% of their body fat within the 10-week study period.
Additional studies suggest that Cissus can also increase the amount of the “happy hormone” serotonin in your blood and will thus yield an effective reduction in appetite which could come particularly handy, when you are dieting.
Apropos dieting: We all know that each and every decrease in caloric intake puts you at risk of losing precious muscle. With its scientifically proven anticatabolic effects, GN Laboratories Cissus Xplode will minimize or totally blunt these losses by reducing the total amount of the catabolic hormone cortisol your body produces and / or reducing its detrimental effects on your skeletal muscle tissue (4, 5, 6). Cissus Xplode will thus take care of the two most important determinants of successful dieting: It accelerates fat loss and protects your hard-earned muscle mass from being burned as fuel – you can hardly expect more from a supplement that’s designed to promote fat reduction, can you?

GN Laboratories Cissus Xplode supports skeletal muscle anabolism

We are not going to pick up on the hilarious statements you may have seen in some of the adverts about how Cissus Quandrangularis would significantly boost your testosterone levels. While there is scientific evidence that this may be the case. However, the evidence is far from being conclusive and further research is clearly necessary.
At least as interesting as its potential testosterone boosting effects and in fact well-established, are the effects Cissus Quadrangularis extracts exert on the synthesis of the catabolic hormone cortisol. By keeping the cortisol levels well within the normal range (4, 5, 6), Cissus will exert highly significant anti-catabolic effects, of which some studies even suggest that they are on par with certain anabolic steroids.
Most of you will probably be aware of the fact that cortisol is a hormone that can – among other things – induce the breakdown of muscle tissue. So, if you are able to keep the cortisol level within a narrow margin and minimize muscle catabolism, this will obviously increase the net muscle gains (identical protein synthesis, lower breakdown = increased muscle mass). In that, it is interesting to note that the efficacy of many anabolic steroids depends to the same, if not even a greater extend on their anti-catabolic vs. their anabolic effects
Furthermore, most users report a significant increase in muscle pump after 10-15 days of using the product. This pump is a direct consequence of Cissus’ ability to increase the blood supply to the musculature. Even if these effects have as of yet not been adequately studied, similar effects have been documented for other plants from the grape family and is most likely brought about by the high flavonoid contents of these plants (3). The increase in vasodilation goes hand in hand with an improved oxygenation and nutrient supply to the muscle, which will further promote muscle growth.

Are there any positive effects on general health users will experience?

The list of general health benefits that have been associated with the use of Cissus Quadrangularis extract in both, traditional medicine and scientific studies, is in fact so long that it would take a whole book to cover them all. Therefore, we decided to stick to a couple of keywords to give you a general idea of what you can expect. Cissus ha antibacterial and antimicrobial effects (1), it can prevent osteoporosis (20), it eases digestive disorders (21, 22), it has anti-inflammatory and analgesic effects (11, 12, 13, 23), it will improve your blood lipids and decrease your cholesterol levels (9) and is a very effective anti-oxidant (24) that will protect your body from free radical damage.


The GN Laboratories Quality Guarantee

We use only the purest, highest grade ingredients the market has to offer. To ensure the constant quality of all our products, we conduct regular laboratory tests to ensure the purity and quality of all ingredients.




  1. Chidambara Murthy KN, Vanitha A, Mahadeva Swamy M, Ravishankar GA. Antioxidant and antimicrobial activity of Cissus quadrangularis L. J Med Food. 2003 Summer;6(2):99-105.
  2. Singh G, Rawat P, and Maurya R. Constituents of Cissus quadrangularis. Nat Prod Res 21: 522-528, 2007
  3. Fitzpatrick DF, Hirschfield SL, and Coffey RG. Endothelium-dependent vasorelaxing activity of wine and other grape products. Am J Physiol 265: H774-778, 1993.
  4. Chopra SS, Patel MR, Awadhiya RP. Studies of Cissus quadrangularis in experimental fracture repair : a histopathological study Indian J Med Res. 1976 Sep;64(9):1365-8
  5. Chopra SS, Patel MR, Gupta LP, Datta IC. Studies on Cissus quadrangularis in experimental fracture repair: effect on chemical parameters in blood Indian J Med Res. 1975 Jun;63(6):824-8.
  6. Prasad GC and Udupa KN. Effect of Cissus Quadrangularis on the Healing of Cortisone Treated Fractures. Indian J Med Res 51: 667-676, 1963.
  7. Mishra, G., et al. (2010). Pharmacological and Therapeutic Activity of Cissus quadrangularis: An Overview. International Journal of PharmTech Research CODEN (USA): April-June, Vol.2, No.2, 1298-1310.
  8. Oben, Julius and Kuate, Dieudonne and Agbor, Gabriel and Momo, Claudia and Talla, Xavio and others. The use of a Cissus quadrangularis formulation in the management of weight loss and metabolic syndrome. Lipids Health Dis, 2006, Ausgabe 5 Seite 24f
  9. Oben, Julius E and Ngondi, Judith L and Momo, Claudia N and Agbor, Gabriel A and Sobgui, CS and others. The use of a Cissus quadrangularis/Irvingia gabonensis combination in the management of weight loss: a double-blind placebo-controlled study. Lipids Health Dis, 2008, Ausgabe 7, Seite 12f
  10. Oben, Julius E and Enyegue, Damaris Mandob and Fomekong, Gilles I and Soukontoua, Yves B and Agbor, Gabriel A and others. The effect of Cissus quadrangularis (CQR-300) and a Cissus formulation (CORE) on obesity and obesity-induced oxidative stress. Lipids Health Dis, 2007, Ausgabe 6, Nummer 4
  11. Ferrandiz M.L., Alcaraz M.J. (1991). Anti-inflammatory activity and inhibition of arachidonic acid metabolism by flavonoids, Agents and Actions. 32 (3–4), 283–288.
  12. Mallika J., Shyamala Devi CS. (2006). Gastroprotective action of Cissus quadrangularis extract against NSAID induced gastric ulcer: role of proinflammatory cytokines and oxidative damage. Biol Interact, 161, 262–70.
  13. Lin, J., et al. (1999). “Preliminary screening of some traditional Zulu medicinal plant for Anti-inflammatory and Anti-microbial activity”, Journal of Ethnopharmacology, 68, 267-274.
  14. Udupa K. N., and Prasad G. C. (1964). Further studies on the effect of Cissus quadrangularis in accelerating fracture healing, Indian J. Med. Res., 52, 26–35.
  15. Sen S.P., et al (1966). Studies on the active constituents. 10 Further studies on the effect of Cissus quadrangularis in accelerating fracture healing, Indian Journal of Medical Research, 52, 26.
  16. Chopra S.S., et al (1976). Studies of Cissus quadrangularis in experimental fracture repair: a histopathological study, Indian Journal of Medical Research, 64(9), 1365–1368.
  17. Canalis H., et al. (1998). Growth factors and the regulation on bone remodeling, Journal of Clinical Investigation, 81, 277– 281.
  18. Prasad G.C., Udupa K.N. (1972). Pathways and site of action of a phytogenic steroid from Cissus quadrangularis, Journal of Research in Indian Medicine, 4, 132.
  19. Udupa K.N., et al (1965). The effect of phytogenic steroid in the accleration of fracture repair, Life Science, 4, 317.
  20. Shirwaikar A, Khan S, Malini S. Antiosteoporotic effect of ethanol extract of Cissus quadrangularis Linn. on ovariectomized rat. J Ethnopharmacol. 2003 Dec;89(2-3):245-50.
  21. Jainu M and Devi CS. Gastroprotective action of Cissus quadrangularis extract against NSAID induced gastric ulcer: role of proinflammatory cytokines and oxidative damage. Chem Biol Interact 161: 262-270, 2006.
  22. Jainu M and Shyamala Devi CS. Attenuation of neutrophil infiltration and proinflammatory cytokines by Cissus quadrangularis: a possible prevention against gastric ulcerogenesis. J Herb Pharmacother 5: 33-42, 2005.
  23. Panthong A, Supraditaporn W, Kanjanapothi D, Taesotikul T, and Reutrakul V. Analgesic, anti-inflammatory and venotonic effects of Cissus quadrangularis Linn. J Ethnopharmacol 110: 264-270, 2007.
  24. Jainu and C.S. Devi. (2005). In vitro and In vivo evaluation of free radical scavenging potential of Cissus quadrangularis, African Journal of Biomedical Research, 8(2), 95-99.


  • Titel:Top Top Top
    Hatte nach 14 Tagen eine eindeutige Besserung meiner Schmerzen in meinem rechten Knie nach Woche 3 schmerzfrei !!!
    Desweiteren habe ich an Gewicht verloren da nur die Einnahme Cissus sich geändert/hinzu geführt wurde schreibe ich Cissus diesen Positiven Effekt zu. Cissus ist ab sofort mein neues dauer Supplement.
  • Titel:Gut, aber irreführender Veggy Aufdruck
    Das Produkt wirkt, nicht schlagartig, sondern eher langfristig. Gelenkschmerzen lassen beständig nach, die Flexibilität verbessert sich. Einen Stern Abzug kostet der Aufdruck Veggy Caps , da die Kapselhülle aus GELATINE besteht.
  • Titel:Ganz gut!
    Nachdem ich mich nach einem Knorpelschaden 4.Grades im Knie einer Mikrofraktur unterziehen musste litt ich monatelang unter starken Schmerzen, die seit der Einnahme von Cissus Explode (bereits nach einer Woche) fast verschwunden sind. Auch der Zustand meiner Arthrose hat sich verbessert sich zunehmend und ich hoffe bald wieder trainieren zu koennen. Ich kann dieses Produkt mit bestem Gewissen weiterempfehlen.
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Directions for GN Cissus Xplode

As a dietary supplement, take 1 capsule 10 minutes prior to breakfast and 1 capsule 10 minutes prior to the last meal of the day. Cissus Xplode™ supports healthy tendons, ligaments, cartilage and joints.

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