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Citrulline malate is one of the most effective nitric oxide boosters on the market. It will provide you with incredible pumps and an increased blood, nutrient and oxygen supply to the muscle. Just like arginine it is a totally benign, naturally occurring compound, albeit with significantly more potent NO boosting effects.
The real innovation is yet not citrulline malate, but the combination of the potent natural nitric oxide booster with our unique Polyhydrate buffering technology. The result is the most bioavailable, uniquely effective citrulline malate supplement your money can buy.
Due to its significantly increased potency Citrulline Polyhydrate will have noticeable effects on skeletal muscle hypertrophy and strength gains. If you train with Citrulline Polyhydrate you will be able to train longer, harder and more efficiently; and due to its beneficial effects on muscle soreness and recovery, you can do so without running the risk of overtraining while experiencing faster and more pronounced gains than ever before.
Citrulline Polyhydrate is completely stimulant free and can thus be taken in the AM and PM and / or be combined with every other pre-workout on the market.
Citrulline Polyhdrate uses the same unique Polyhydrate Buffering Technology you know from Creatine Polyhydrate, Glutamine Polyhydrate, Arginine Polyhydrate and DAA Polyhydrate. As different as these products may be, they all have one thing in common: An unrivalled bioavailability which they owe to the unique combination of an acid buffer that protects the active ingredients from being destroyed by the stomach acid and a precisely matched dose of probiotic bacteria which increase the absorption and bioavailability of Citrulline Polyhydrate by an additional 20%.
On a gram to gram basis Citrulline Polyhydrate is thus significantly more potent than regular citrulline malate. With almost 100% of the active compound being actually absorbed, Citrulline Polyhydrate will produce maximal results at minimal dosages.
Citrulline is a naturally occurring amino acid that is involved in a whole host of biological processes in our body. For bodybuilders the most important of these processes probably is the production of nitric oxide. The substance that's responsible for widening the arteries, increasing the oxygen supply to the muscle and increasing the pump you feel while you train.
Usually nitric oxide is produced from arginine via endothelial nitric oxide synthase (eNOS). In this process arginine acts as a trigger and substrate at a time. In practice, an increased availability of arginine will thus increase the production of eNOS and accelerate its own conversion to nitric oxide.
By now, you are probably asking yourselves how the previously discussed process is related to citrulline. It would after all appear more prudent to use arginine instead – wouldn't it? Indeed, it would. In practice, the ingestion of a large bolus of arginine will yet inevitably increase its own breakdown in the liver. The overall impact on the amount of arginine in the blood would be negligible and the corresponding increase in nitric oxide production at best mediocre.
This is where citrulline comes into play. In contrast to arginine it will bypass the liver, arrive at the kidneys, which will then convert it to arginine (1, 2) and release it into systemic circulation. The net result, a significant increase in nitric oxide production has been confirmed in a number of scientific studies (3).
Nitric oxide is present in the innermost layer of the blood vessels. In those so-called endothelial cells, it acts as a messenger molecule that causes the musculature of the blood vessels to relax. The arteries widen and the blood flow increases. While you train you will feel this effect in form of skin bursting pumps and an increased vascularity. These are yet only the most obvious benefits which will be complemented by an increase in blood, oxygen, nutrient and hormone supply during your workouts.
The citrulline induced increase in oxygen and nutrient supply, will thus allow you train longer and harder than ever. The optimal hormone supply will allow for maximal strength and size gains and the accelerated clearance of metabolic waste will postpone the onset of muscular fatigue, accelerate your recovery and minimize your risk of overtraining.
In addition, increased levels of nitric oxide have been shown to improve the contractile properties of the musculature, increase the uptake of glucose, the recruitment of satellite cells and the production of myotrophic (anabolic) factors.
Even the pump itself or rather the corresponding increase in cell volume will directly contribute to muscle growth. Several scientific studies have been able to show that the cell swelling exerts profound anabolic effect on the muscle tissue. This mechanism is directly related to the anabolic signaling processes that are triggered, when the increase in cell volume stretches the muscle fascia (10). Fascia are a tightly interwoven network of fibrous tissue that is wrapped around the muscle fibers to provide structural integrity.
Next to the increased pump and vasodilation, the improved oxygenation, nutrient supply and removal of metabolic waste have been shown to reduce muscle soreness and to increase the maximal training volume (4). Due to its direct beneficial effects on skeletal muscle protein synthesis citrulline will directly promote the accrual of lean muscle tissue (5, 6); and with its general ability to improve the production of ATP it will increase both your aerobic and anaerobic training performance, significantly (7).
Furthermore, citrulline is the rate limiting factor for the clearance of ammoniac from the blood (8, 9). Ammoniac is a toxic substance that's produced during intense training sessions. It will have negative effects on your performance, health and regenerative capacity. It's beneficial effects on the urea cycle and the corresponding increase in ammoniac clearance are thus an important mechanism behind Citrulline Polyhydrate's ability to help you recover faster during and after your workouts.
In spite of the fact that stomach acid plays an extremely important role in the digestive process, it will also reduce the bioavilability of orally consumed amino acids and other agents, which are commonly used in dietary supplements. When these molecules are exposed to the acidic milieu of the stomach, they undergo chemical changes that will reduce or change their biological effects. Our unique Polyhdrate Buffering Technology, which has been used in several other GN Laboratory innovations such as Creatine Polyhydrate, Glutamine Polyhydrate, Beta-Alanine Polyhydrate, Arginine Polyhydrate and DAA Polyhydrate, with huge success, protects the active agents in Citrulline Polyhydrate from the destructive effects of stomach acid. This results in a significant increase in bioavailability and an unparalleled effectiveness.
Our goal is to provide our customers with cutting edge dietary supplements. Therefore we have used the recent insights into the multifaceted health benefits of probiotics to enhance the bioavailability of Citrulline Polyhydrate even further.
The latest experimental evidence suggests that probiotics will increase the bioavailability and absorption of amino acids in the digestive tract by 20%. By adding micro-encapsulated probiotics (Bifidobacterium Bifidum, Lactobacillus Acidophilus und Lactobacillus Casei) to the formula we have thus been able to produce the probably most bioavailable citrulline supplement on the market.
Next to their ability to boost the absorption of amino acids, probiotics have also been shown to have a series of additional health befits. Lactobacilli, for example, regulate the pH of the chime in the small intestine and protect the gastrointestinal tract from foodborne pathogens. The bifido bacteria in Citrulline Polyhydrate, on the other hand, will keep the pathogenic bacteria and fungi in the large intestine in check.
Moreover, the microbial metabolic products of probiotics from the bifido strain supply the coloncytes (the cells in the wall of the intestine) with energy. Without this constant supply of energy, the colonocytes would die. In view of the fact that the immune cells in the gut depend on the same metabolic products as fuel sources, it is thus no wonder that a lack of "good" bacterial will result in various health problems ranging from mild digestive problems, over a reduced systemic immunity to severe diseases of the digestive tract such as Morbus Crohn.
Unfortunately, probiotics are highly susceptible to environmental influences. To protect their integrity, they thus have to be administered in microencapsulated form. It goes without saying that regular probiotics are significantly cheaper. According to our company policy to use only the highest grade ingredients, we did however never even think about using regular probiotics. Without the encapsulation they would not survive the transit through the stomach to their destinations in the small and large intestine tract unharmed and none of the previously mentioned benefits could be realized.
We use only the purest, highest grade ingredients the market has to offer. To ensure the constant quality of all our products, we conduct regular laboratory tests to ensure the purity and quality of all ingredients.
As a dietary supplement, take 20-30 minutes prior to training with approximately 6 ounces of water or juice, on an empty stomach. On non-training days, take one (1) serving (1 scoop) daily, first thing in the morning, on an empty stomach, or as directed by a qualified healthcare practitioner.
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