Citrulline Polyhydrate - GN Laboratories

18,26 €

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/ Content: 200g
0.3 kg
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  • Content: 200g
  • Form : Powder

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We've made one of the most potent natural nitric oxide booster even better!

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Available Now!

18,26 €

91,28 € per Kilo
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0.3 kg
Lieferzeit 1-2 Werktage
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Citrulline Polyhydrate

We've made one of the most potent natural nitric oxide booster even better !

Product highlight

  • significant increases in nitric oxide production
  • extreme skin-bursting pumps
  • based on a natural, non-hazardous amino acid
  • accelerated muscle and strength gains
  • postponed onset of fatigue
  • faster regeneration between sets and workouts
  • improved nutrient, oxygen and hormone supply to the musculature
  • prevents the over-acidification of the trained muscles
  • reduces muscle soreness after workouts
  • increases the use and production of ATP
  • augments protein synthesis
  • superior bioavailability
  • fast and complete absorption
  • innovatively buffered for maximal molecular stability within the digestive tract
  • added probiotics for an increased bioavailability
  • 100% stimulant-free, can be used in the AM and PM
  • no additional fillers or questionable additives

Citrulline malate is one of the most effective nitric oxide boosters on the market. It will provide you with incredible pumps and an increased blood, nutrient and oxygen supply to the muscle. Just like arginine it is a totally benign, naturally occurring compound, albeit with significantly more potent NO boosting effects.
The real innovation is yet not citrulline malate, but the combination of the potent natural nitric oxide booster with our unique Polyhydrate buffering technology. The result is the most bioavailable, uniquely effective citrulline malate supplement your money can buy.

Due to its significantly increased potency Citrulline Polyhydrate will have noticeable effects on skeletal muscle hypertrophy and strength gains. If you train with Citrulline Polyhydrate you will be able to train longer, harder and more efficiently; and due to its beneficial effects on muscle soreness and recovery, you can do so without running the risk of overtraining while experiencing faster and more pronounced gains than ever before.
Citrulline Polyhydrate is completely stimulant free and can thus be taken in the AM and PM and / or be combined with every other pre-workout on the market.

Why is Citrulline Polyhydrate superior to regular citrulline malate products?

Citrulline Polyhdrate uses the same unique Polyhydrate Buffering Technology you know from Creatine Polyhydrate, Glutamine Polyhydrate, Arginine Polyhydrate and DAA Polyhydrate. As different as these products may be, they all have one thing in common: An unrivalled bioavailability which they owe to the unique combination of an acid buffer that protects the active ingredients from being destroyed by the stomach acid and a precisely matched dose of probiotic bacteria which increase the absorption and bioavailability of Citrulline Polyhydrate by an additional 20%.

On a gram to gram basis Citrulline Polyhydrate is thus significantly more potent than regular citrulline malate. With almost 100% of the active compound being actually absorbed, Citrulline Polyhydrate will produce maximal results at minimal dosages.

Citrulline Malate and its effects on nitric oxide production

Citrulline is a naturally occurring amino acid that is involved in a whole host of biological processes in our body. For bodybuilders the most important of these processes probably is the production of nitric oxide. The substance that's responsible for widening the arteries, increasing the oxygen supply to the muscle and increasing the pump you feel while you train.
Usually nitric oxide is produced from arginine via endothelial nitric oxide synthase (eNOS). In this process arginine acts as a trigger and substrate at a time. In practice, an increased availability of arginine will thus increase the production of eNOS and accelerate its own conversion to nitric oxide.

By now, you are probably asking yourselves how the previously discussed process is related to citrulline. It would after all appear more prudent to use arginine instead – wouldn't it? Indeed, it would. In practice, the ingestion of a large bolus of arginine will yet inevitably increase its own breakdown in the liver. The overall impact on the amount of arginine in the blood would be negligible and the corresponding increase in nitric oxide production at best mediocre.
This is where citrulline comes into play. In contrast to arginine it will bypass the liver, arrive at the kidneys, which will then convert it to arginine (1, 2) and release it into systemic circulation. The net result, a significant increase in nitric oxide production has been confirmed in a number of scientific studies (3).

What are the benefits of an increased nitric oxide production?

Nitric oxide is present in the innermost layer of the blood vessels. In those so-called endothelial cells, it acts as a messenger molecule that causes the musculature of the blood vessels to relax. The arteries widen and the blood flow increases. While you train you will feel this effect in form of skin bursting pumps and an increased vascularity. These are yet only the most obvious benefits which will be complemented by an increase in blood, oxygen, nutrient and hormone supply during your workouts.

The citrulline induced increase in oxygen and nutrient supply, will thus allow you train longer and harder than ever. The optimal hormone supply will allow for maximal strength and size gains and the accelerated clearance of metabolic waste will postpone the onset of muscular fatigue, accelerate your recovery and minimize your risk of overtraining.

In addition, increased levels of nitric oxide have been shown to improve the contractile properties of the musculature, increase the uptake of glucose, the recruitment of satellite cells and the production of myotrophic (anabolic) factors.

Even the pump itself or rather the corresponding increase in cell volume will directly contribute to muscle growth. Several scientific studies have been able to show that the cell swelling exerts profound anabolic effect on the muscle tissue. This mechanism is directly related to the anabolic signaling processes that are triggered, when the increase in cell volume stretches the muscle fascia (10). Fascia are a tightly interwoven network of fibrous tissue that is wrapped around the muscle fibers to provide structural integrity.

Additional interesting properties of citrulline malate

Next to the increased pump and vasodilation, the improved oxygenation, nutrient supply and removal of metabolic waste have been shown to reduce muscle soreness and to increase the maximal training volume (4). Due to its direct beneficial effects on skeletal muscle protein synthesis citrulline will directly promote the accrual of lean muscle tissue (5, 6); and with its general ability to improve the production of ATP it will increase both your aerobic and anaerobic training performance, significantly (7).

Furthermore, citrulline is the rate limiting factor for the clearance of ammoniac from the blood (8, 9). Ammoniac is a toxic substance that's produced during intense training sessions. It will have negative effects on your performance, health and regenerative capacity. It's beneficial effects on the urea cycle and the corresponding increase in ammoniac clearance are thus an important mechanism behind Citrulline Polyhydrate's ability to help you recover faster during and after your workouts.

The Unique Polyhydrate Buffering Technology

In spite of the fact that stomach acid plays an extremely important role in the digestive process, it will also reduce the bioavilability of orally consumed amino acids and other agents, which are commonly used in dietary supplements. When these molecules are exposed to the acidic milieu of the stomach, they undergo chemical changes that will reduce or change their biological effects. Our unique Polyhdrate Buffering Technology, which has been used in several other GN Laboratory innovations such as Creatine Polyhydrate, Glutamine Polyhydrate, Beta-Alanine Polyhydrate, Arginine Polyhydrate and DAA Polyhydrate, with huge success, protects the active agents in Citrulline Polyhydrate from the destructive effects of stomach acid. This results in a significant increase in bioavailability and an unparalleled effectiveness.

Why does Citrulline Polyhydrate contain additional probiotics

Our goal is to provide our customers with cutting edge dietary supplements. Therefore we have used the recent insights into the multifaceted health benefits of probiotics to enhance the bioavailability of Citrulline Polyhydrate even further.

The latest experimental evidence suggests that probiotics will increase the bioavailability and absorption of amino acids in the digestive tract by 20%. By adding micro-encapsulated probiotics (Bifidobacterium Bifidum, Lactobacillus Acidophilus und Lactobacillus Casei) to the formula we have thus been able to produce the probably most bioavailable citrulline supplement on the market.

Next to their ability to boost the absorption of amino acids, probiotics have also been shown to have a series of additional health befits. Lactobacilli, for example, regulate the pH of the chime in the small intestine and protect the gastrointestinal tract from foodborne pathogens. The bifido bacteria in Citrulline Polyhydrate, on the other hand, will keep the pathogenic bacteria and fungi in the large intestine in check.

Moreover, the microbial metabolic products of probiotics from the bifido strain supply the coloncytes (the cells in the wall of the intestine) with energy. Without this constant supply of energy, the colonocytes would die. In view of the fact that the immune cells in the gut depend on the same metabolic products as fuel sources, it is thus no wonder that a lack of "good" bacterial will result in various health problems ranging from mild digestive problems, over a reduced systemic immunity to severe diseases of the digestive tract such as Morbus Crohn.

Unfortunately, probiotics are highly susceptible to environmental influences. To protect their integrity, they thus have to be administered in microencapsulated form. It goes without saying that regular probiotics are significantly cheaper. According to our company policy to use only the highest grade ingredients, we did however never even think about using regular probiotics. Without the encapsulation they would not survive the transit through the stomach to their destinations in the small and large intestine tract unharmed and none of the previously mentioned benefits could be realized.

The GN Laboratories Quality Guarantee

We use only the purest, highest grade ingredients the market has to offer. To ensure the constant quality of all our products, we conduct regular laboratory tests to ensure the purity and quality of all ingredients.


  1. Schwedhelm E, Maas R, Freese R, Jung D, Lukacs Z, Jambrecina A, Spickler W, Schulze F, Böger RH. Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism. Br J Clin Pharmacol. 2008 Jan;65(1):51-9. Epub 2007 Jul 27.
  2. Dhanakoti SN, Brosnan JT, Herzberg GR, Brosnan ME. Renal arginine synthesis: studies in vitro and in vivo. Am J Physiol. 1990 Sep;259(3 Pt 1):E437-42.
  3. Schwedhelm E, Maas R, Freese R, Jung D, Lukacs Z, Jambrecina A, Spickler W, Schulze F, Böger RH. Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism. Br J Clin Pharmacol. 2008 Jan;65(1):51-9.
  4. Pérez-Guisado J, Jakeman PM. Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness. J Strength Cond Res. 2010 May;24(5):1215-22.
  5. Osowska S, Duchemann T, Walrand S, Paillard A, Boirie Y, Cynober L, Moinard C. Citrulline modulates muscle protein metabolism in old malnourished rats. Am J Physiol Endocrinol Metab. 2006 Sep;291(3):E582-6. Epub 2006 Apr 11
  6. S Osowska, C Moinard, N Neveux, C Loi, L Cynober. Citrulline increases arginine pools and restores nitrogen balance after massive intestinal resection. Gut 2004;53:1781–1786.
  7. Bendahan D, Mattei JP, Ghattas B, Confort-Gouny S, Le Guern ME, Cozzone PJ. Citrulline/malate promotes aerobic energy production in human exercising muscle. Br J Sports Med. 2002 Aug;36(4):282-9.
  8. Wilkerson JE, Batterton DL, Horvath SM. Exercise-induced changes in blood ammonia levels in humans. Eur J Appl Physiol Occup Physiol. 1977 Dec 22;37(4):255-63.
  9. Brodan V, Kuhn E, Pechar J, Tomková D. Changes of free amino acids in plasma of healthy subjects induced by physical exercise. Eur J Appl Physiol Occup Physiol. 1976 Mar 9;35(1):69-77.
  10. Antonio, J., & Gonyea, W. J. (1993). Progressive stretch overload of skeletal muscle results in hypertrophy before hyperplasia. Journal of Applied Physiology, 75(3), 1263-1271.


  • Titel:Gutes Citrullin
    Wirkt gut, Geschmack ist nur sehr leicht vorhanden, schmeckt viel mehr neutral und ist einfach zu trinken.
  • Titel:angenehmer Pump
    spreche nicht so stark auf Booster an. Aber bei 6gr finde ich ihn angenehm.
    nicht extrem aber deutlich spürbar, Mich hat das Produkt angenehm überrascht, Preislich ist es obere Kategorie, aber für mich ok
  • Titel:Absolute Empfehlung
    durch eigenes Anmischen durch verschiedene Substanzen spart man eine Menge Geld gegenüber fertigen Hardcore Boostern und kann so selbst bestimmen, wie hart es heute knallen soll.
  • Titel:wirkung top, geschmack flop
    Habe auch 6g genommen da ich allgemein auf Citrullin schlecht anspreche. Pump ist super damit. Allerdings ist der Geschmack fürchterlich. Habe Lemon Cola und orange probiert. Beides schmeckt merkwürdig bitter und extrem nach chemie. Pur ist es ungenießbar. Mixe es mit BCAA's, da geht es.
  • Titel:Top
    Man liest über den Wirkstoff nur gutes. Allerdings glaube ich das man lieber 6g nehmen sollte, deshalb nur 4 Sterne. Aber dann wäre es auch zu teuer!
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As a dietary supplement, take 20-30 minutes prior to training with approximately 6 ounces of water or juice, on an empty stomach. On non-training days, take one (1) serving (1 scoop) daily, first thing in the morning, on an empty stomach, or as directed by a qualified healthcare practitioner.

Citrullin Malat

Citrullin wurde zuerst aus der Wassermelone isoliert und gehört nicht zu den Bausteinen von Proteinen. Es ist ein Zwischenprodukt bei der Umwandlung der Aminosäure Ornithin zu Arginin und trägt im Lauf des Harnstoffzyklus dazu bei, Ammoniak zu entgiften. Ammoniak ist ein schädliches Abfallprodukt des Aminosäurenstoffwechsels, das schnell entsorgt werden muss, da es andernfalls zur Muskelerschöpfung führt und die Denkleistung negativ beeinträchtigen kann. Letzteres entsteht bei vielen Prozessen im Stoffwechsel, vor allem beim Abbau von Proteinen. Da Ammoniak als starkes Nervengift wirken kann, muss es so schnell wie möglich neutralisiert werden. Ich wurde zuerst am Citrullin-Malat von ungefähr 5 Jahren aufmerksam, als ich eine Zusammenfassung einer Studie gelesen habe, die an einem Basketballspieler durchgeführt wurde indem es hieß das Citrullin-Malat die aeroben Performance bedeutend verbessert. Ich machte mich sofort auf der suche nach dieser Substanz, weil ich immer nach neue Mittel suche meine athletische Leistung zu erhöhen. Leider waren zu dieser Zeit, die Kosten der Produktion dieses Mittels enorm teuer, aber glücklicherweise wurde dieses Wundernährstoff nach kurze Zeit, durch neue Herstellungstechniken, zum Ersten Mal für uns Athleten hergestellt worden.


Bedarf im Sport

Diese Aminosäure wird im Körper zu Arginin umgewandelt und kann die Stickoxid- (NO) und die Wachstumshormon- Produktion verbessern. Cirtrullin ermöglicht ein längeres Training, indem es das Einsetzen der Erschöpfung verzögert.
Citrullin wird relativ zügig im Körper im Arginin umgewandelt. Auf diese Weise liegt mehr Arginin für die Stickoxid-Produktion und die Auslösung von Wachstumshormon vor. Citrullin-Malat ist die übliche Darreichungsform dieser Aminosäure (Citrullin ist dabei an Malat, oder Apfelsäure, gebunden). Diese Kombination kann auch das beim Training entstandene Lactat (Milchsäure) neutralisiert. Auf diese Weise wird die Erschöpfung beim Training verzögert.
Man kann 3g Citrullin (als Citrullin-Malat) zweimal täglich auf nüchternen Magen nehmen. An Trainingstagen sollte man eine Dosierung 30-60 Minuten vor dem Training zu sich nehmen und die zweite unmittelbar nach dem Ende des Trainings.



  1. Bendahan D, Mattei JP, Ghattas B, et al. 2002. Citrulline/malate promotes aerobic energy production in human exercising muscle. Br J Sports Med; 36(4):282-9.
  2. Briand J, Blehaut H, Calvayrac R, Laval-Martin D. 1992. Use of a microbial model for the determination of drug effects on cell metabolism and energetics: study of citrulline-malate. Biopharm Drug Dispos; 13(1):1-22.
  3. Callis A, Magnan de Bornier B, Serrano JJ, et al. 1991.Activity of citrulline malate on acid-base balance and blood ammonia and amino acid levels. Study in the animal and in man. Arzneimittelforschung; 41(6):660-3.
  4. Fornaris E, Vanuxem J, Duflot P, et al. 1984. [Pharmacological/clinical approach of citrulline malate activity: study of blood lactate levels during standardized muscular exercise]. Gazette Medicale, 91(11):125-128.
  5. Goubel F, Vanhoutte C, Allaf O, et al. 1997. Citrulline malate limits increase in muscle fatigue induced by bacterial endotoxins. Can J Physiol Pharmacol; 75(3):205-7.
  6. Hartman WJ, Torre PM, Prior RL. 1994. Dietary citrulline but not ornithine counteracts dietary arginine deficiency in rats by increasing splanchnic release of citrulline. J Nutr; 124(10):1950-60.
  7. Janeira MA, Santos PJ. 1998. Citrulline malate effects on the aerobic-anaerobic threshold and in post-exercise blood lactate recovery. Med Sci Sports Exerc; 30(5 supp): abstract 881.
  8. Vanuxem D, Duflot JC, Prevot H, et al. 1990. [Influence of an anti-astenia agent, citrulline malate, on serum lactate and ammonia kinetics during a maximum exercise test in sedentary subjects]. Sem Hop Paris; 66(9):477-481.
  9. Waugh WH, Daeschner CW, Files BA, et al. 2001. Oral citrulline as arginine precursor may be beneficial in sickle cell disease: early phase, two results. J Natl Med Assoc; 93(10):363-71.

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