B-Complex Biotech

B-Complex Biotech

Rating
0/5

MULTIVITAMIN- UND MINERALIEN-KOMPLEX MIT SCHWERPUNKT AUF VITAMIN B UND ZUSÄTZLICHEN KRÄUTER-EXTRAKTEN!

: Biotech USA

: 4199

: 60 Tableten

: Vitamine & Mineralstoffe

25 G-Points
  • 12,90 €

    9,90 €

    inkl. MwSt.

    Einzelpreis 0,10 € pro Tablette

    Menge :

    MULTIVITAMIN- UND MINERALIEN-KOMPLEX MIT SCHWERPUNKT AUF VITAMIN B UND ZUSÄTZLICHEN KRÄUTER-EXTRAKTEN!

    IN 1 TABLETTE:

    • 12 Vitamine
    • 4 Mineralien
    • 7 Kräuter- und natürliche Pflanzen-Extrakte

    Ein ausgewogener Vitamin-B-Komplex, der mit 8 lebenswichtigen B-Vitaminen versorgt sowie mit weiteren Vitaminen, Mineralien, Antioxidantien und Kräutern. B-Vitamine unterstützen den Kohlenhydratstoffwechsel und die Energieproduktion. Angereichert mit wertvollen Inhaltsstoffen wie Guarana, Ginseng, Bienenpollen und Bioflavonoiden.
    Vitamin B2 ist wichtig für die Energieproduktion und trägt zum Erhalt gesunder Schleimhäute, Haut und Sehkraft bei.
    Niacin unterstützt eine gesunde psychologische Funktion und reduziert zudem Abgespanntheit und Müdigkeit.
    Vitamin B6 spielt eine Rolle in der Aufrechterhaltung eines normalen Homocysteinspiegels, reguliert die Hormonaktivität und unterstützt einen gesunden Protein- und Glykogenstoffwechsel.
    Folat trägt ebenfalls zu einer normalen Aminosäurensynthese und Blutbildung bei und unterstützt die gesunde Funktion des Immunsystems.
    Vitamin B12 ist notwendig für die Energieproduktion, eine normale psychologische Funktion und die Produktion der roten Blutkörperchen.
    Biotin arbeitet als Coenzym und trägt zum normalen Makronährstoff-Stoffwechsel bei. Es ist eine Nahrungsunterstützung für gesunde Haut und Haare.
    Vitamin-B-Komplex enthält ebenfalls wichtige Mineralien wie Eisen, das an der Energieverwertung beteiligt ist.
    Nahrungsergänzungsmittel ersetzen nicht eine ausgewogene, vielseitige Ernährung und einen gesunden Lebensstil.

    Biotin

    Vitamin B7 / Biotin

    Überblick

    Biotin ist ein Vitamin, das in geringen Mengen in zahlreichen Nahrungsmitteln vorkommt.

    Biotin wird zur Verhinderung und Behandlung eines mit der Schwangerschaft, einer langfristigen künstlichen Ernährung, einer Fehlernährung oder einem rapiden Gewichtsabbau in Verbindung stehenden Biotinmangels eingesetzt. Es wird außerdem oral bei Haarausfall, brüchigen Nägeln, Hautausschlag bei Kindern (seborrhoische Dermatitis), Diabetes und leichten Depressionen verwendet.

     

    Wie wirkt Biotin?

    Biotin ist eine wichtige Komponente von Enzymen des menschlichen Körpers, die bestimmte Substanzen wie Fette, Kohlenhydrate und andere aufbrechen.

    Es gibt keinen wirklich guten Labortest, um einen Biotinmangel feststellen zu können, weshalb ein solcher Mangel für gewöhnlich anhand seiner Symptome identifiziert wird. Diese Symptome umfassen dünner werdendes Haar, was häufig von einem Verlust der Haarfarbe begleitet wird, sowie einen roten, schuppigen Hautausschlag um Augen, Nase und Mund. Weitere, das Nervensystem betreffende Symptome umfassen Depressionen, Erschöpfung, Halluzinationen und ein kribbelndes Gefühl in Armen und Beinen. Es gibt Hinweise darauf, dass Diabetes zu einem Biotinmangel führen könnte.BIOTIN Uses & Effectiveness

    Likely Effective for:

    • ·Treating and preventing biotin deficiency. Symptoms of deficiency include thinning of the hair (often with loss of hair color), and red scaly rash around the eyes, nose, and mouth. Other symptoms include depression, listlessness, hallucinations, and tingling in the arms and legs. There is some evidence that cigarette smoking may cause mild biotin deficiency.

    Possibly Ineffective for:

    • ·Skin rash in infants (seborrheic dermatitis).

    Insufficient Evidence for:

    • ·Hair loss. There is some preliminary evidence that hair loss can be reduced when biotin is taken by mouth in combination with zinc while a cream containing the chemical compound clobetasol propionate (Olux, Temovate) is applied to the skin.
    • ·Diabetes. Biotin alone doesn’t seem to affect blood sugar levels in people with type 2 diabetes. However, there is some evidence that a combination of biotin and chromium (Diachrome, Nutrition 21) might lower blood sugar in people with diabetes, whose diabetes is poorly controlled by prescription medicines. Other early evidence shows that the same combination reduces ratios of total cholesterol levels to “good” high-density lipoprotein (HDL) cholesterol, “bad” low-density lipoprotein (LDL) cholesterol to HDL cholesterol, and non-HDL to HDL cholesterol in people with type 2 diabetes.
    • ·Diabetic nerve pain. There is some evidence that biotin can reduce nerve pain in people with diabetes.
    • ·Brittle fingernails and toenails. Biotin might increase the thickness of fingernails and toenails in people with brittle nails.
    • ·Other conditions.

    More evidence is needed to rate biotin for these uses.

     

    BIOTIN Side Effects & Safety

    Biotin is LIKELY SAFE for most people when taken appropriately and by mouth. Biotin is well tolerated when used at recommended dosages. It is POSSIBLY SAFE when injected into the muscles and used appropriately.

    Special Precautions & Warnings:

    Pregnancy and breast-feeding: Biotin is POSSIBLY SAFE when used in recommended amounts during pregnancy and breast-feeding.

    Kidney dialysis: People receiving kidney dialysis may need extra biotin. Check with your health care provider.

    BIOTIN Interactions 

    We currently have no information for BIOTIN Interactions

    BIOTIN Dosing

    The appropriate dose of biotin depends on several factors such as the user’s age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for biotin. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

    There is no recommended dietary allowance (RDA) established for biotin. The adequate intakes (AI) for biotin are 7 mcg for infants 0-12 months, 8 mcg for children 1-3 years, 12 mcg for children 4-8 years, 20 mcg for children 9-13 years, 25 mcg for adolescents 14-18 years, 30 mcg for adults over 18 years and pregnant women, and 35 mcg for breast-feeding women.

     

    Wie effektiv ist Biotin?

    Biotin ist effektiv, wenn es zur Vorbeugung und Behandlung eines Biotinmangels verwendet wird. Symptome eines Biotinmangels umfassen dünner werdendes Haar (häufig begleitet von einem Verlust der Haarfarbe) und einen roten, schuppigen Hautausschlag um Augen, Nase und Mund. Weitere Symptome umfassen Depressionen, Lethargie, Halluzinationen und ein kribbelndes Gefühl in Armen und Beinen. Es gibt Hinweise darauf, dass Rauchen einen milden Biotinmangel hervorrufen könnte.

    Biotin ist zur Behandlung eines Hautausschlages bei Kindern (seborrhoische Dermatitis) wahrscheinlich ineffektiv.

    Es gibt nicht genügend wissenschaftliche Daten, um eine Aussage bezüglich der Effektivität von Biotin bei folgenden Anwendungsbereichen treffen zu können:

    • Haarausfall: Es gibt vorläufige Studienergebnisse, die darauf hindeuten, dass Haarausfall reduziert werden kann, wenn Biotin in Kombination mit Zink oral eingenommen wird, während gleichzeitig eine Creme, die die chemische Verbindung Clostebasol Propionat enthält (Olux, Temovate), auf die Haut aufgetragen wird.
    • Diabetes: Biotin alleine scheint die Blutzuckerspiegel bei Menschen, die unter Diabetes vom Typ 2 leiden, nicht zu beeinflussen. Es gibt jedoch Hinweise darauf, dass eine Kombination von Biotin und Chrom den Blutzucker bei Diabetikern, deren Diabetes nur schlecht mit Hilfe von Medikamenten kontrolliert wird, senken könnte. Andere Studienergebnisse zeigen, dass dieselbe Kombination das Verhältnis der Gesamtcholesterinspiegel zu den Spiegeln des guten HDL Cholesterins, das Verhältnis der Spiegel des schlechten LDL Cholesterins zu den Spiegeln des guten HDL Cholesterins und das Verhältnis der nicht HDL Cholesterinspiegel zu den HDL Cholesterinspiegeln bei Menschen mit Diabetes vom Typ 2 reduziert.
    • Nervenschmerzen bei Diabetikern: Es gibt Hinweise darauf, dass Biotin Nervenschmerzen bei Diabetikern reduzieren kann. 
    • Brüchige Finger- und Zehennägel: Biotin könnte die Dicke von Finger- und Zehennägeln bei Menschen mit brüchigen Nägeln erhöhen.

    Es bedarf weiterer wissenschaftlicher Untersuchungen, um die Effektivität von Biotin bei diesen Anwendungen bewerten zu können.

     

    Sicherheit und Nebenwirkungen

    Biotin ist für die meisten Menschen bei einer oralen Einnahme in angemessenen Mengen wahrscheinlich sicher und unbedenklich. Biotin ist bei einer Einnahme in den empfohlenen Mengen gut verträglich. Biotin ist bei einer intramuskulösen Injektion möglicherweise sicher und unbedenklich.

     

    Vorsichtsmaßnahmen und Warnungen

    Schwangerschaft und Stillzeit: Biotin bei einer Verwendung in den empfohlenen Mengen während Schwangerschaft und Stillzeit möglicherweise sicher und unbedenklich.

    Nierendialyse: Menschen, die sich einer Nierendialyse unterziehen müssen, könnten zusätzliches Biotin benötigen.

     

    Wechselwirkungen

    Zum augenblicklichen Zeitpunkt liegen keine Informationen über Wechselwirkungen von Biotin mit Medikamenten oder Supplements vor.

     

    Dosierung

    Für Biotin ist kein festgelegter täglicher Bedarf definiert. Eine adäquate Zufuhr liegt für Kinder bis 12 Monaten bei 7 mcg, für Kinder von 1 bis 3 Jahren bei 8 mcg, bei Kindern von 4 bis 8 Jahren bei 12 mcg, bei Kindern von 9 bis 13 Jahren bei 20 mcg, bei Jugendlichen von 14 bis 18 Jahren bei 25 mcg, bei Erwachsenen über 18 Jahren und schwangeren Frauen bei 30 mcg und bei stillenden Frauen bei 35 mcg.

     

    Referenzen:

    1. Barry, M. A., Campos, S. K., Ghosh, D., Adams, K. E., Mok, H., Mercier, G. T., and Parrott, M. B. Biotinylated gene therapy vectors. Expert.Opin.Biol.Ther. 2003;3(6):925-940. View abstract.
    2. Baumgartner, M. R. Molecular mechanism of dominant expression in 3-methylcrotonyl-CoA carboxylase deficiency. J Inherit.Metab Dis. 2005;28(3):301-309. View abstract.
    3. Becker, L. C., Bergfeld, W. F., Belsito, D. V., Klaassen, C. D., Marks, J. G., Jr., Shank, R. C., Slaga, T. J., Snyder, P. W., and Alan, Andersen F. Final report of the safety assessment of allantoin and its related complexes. Int J Toxicol. 2010;29(3 Suppl):84S-97S. View abstract.
    4. Biotin and fatty acid requirements for lymphocyte response. Nutr.Rev. 1980;38(3):126-127. View abstract.
    5. Bliss, D. Z., McLaughlin, J., Jung, H. J., Lowry, A., Savik, K., and Jensen, L. Comparison of the nutritional composition of diets of persons with fecal incontinence and that of age- and gender-matched controls. J Wound.Ostomy.Continence.Nurs. 2000;27(2):90-97. View abstract.
    6. Boas, M. A. The Effect of Desiccation upon the Nutritive Properties of Egg-white. Biochem.J 1927;21(3):712-724. View abstract.
    7. Bohrer, D., do Nascimento, P. C., Binotto, R., Becker, E., and Pomblum, S. Contribution of the raw material to the aluminum contamination in parenterals. JPEN J Parenter.Enteral Nutr. 2002;26(6):382-388. View abstract.
    8. Bolander, F. F. Vitamins: not just for enzymes. Curr.Opin.Investig.Drugs 2006;7(10):912-915. View abstract.
    9. Bowman, B. B., Selhub, J., and Rosenberg, I. H. Intestinal absorption of biotin in the rat. J Nutr. 1986;116(7):1266-1271. View abstract.
    10. Brenner, S. and Horwitz, C. Possible nutrient mediators in psoriasis and seborrheic dermatitis. II. Nutrient mediators: essential fatty acids; vitamins A, E and D; vitamins B1, B2, B6, niacin and biotin; vitamin C selenium; zinc; iron. World Rev.Nutr.Diet. 1988;55:165-182. View abstract.
    11. Burnett, R., Guichard, Y., and Barale, E. Immunohistochemistry for light microscopy in safety evaluation of therapeutic agents: an overview. Toxicology 4-11-1997;119(1):83-93. View abstract.
    12. Campistol, J. [Convulsions and epileptic syndromes of the newborn infant. Forms of presentation, study and treatment protocols]. Rev.Neurol. 10-1-2000;31(7):624-631. View abstract.
    13. Carey, P. R., Sonnichsen, F. D., and Yee, V. C. Transcarboxylase: one of nature's early nanomachines. IUBMB.Life 2004;56(10):575-583. View abstract.
    14. Colombo, V. E., Gerber, F., Bronhofer, M., and Floersheim, G. L. Treatment of brittle fingernails and onychoschizia with biotin: scanning electron microscopy. J Am.Acad.Dermatol. 1990;23(6 Pt 1):1127-1132. View abstract.
    15. Crisp, S. E., Griffin, J. B., White, B. R., Toombs, C. F., Camporeale, G., Said, H. M., and Zempleni, J. Biotin supply affects rates of cell proliferation, biotinylation of carboxylases and histones, and expression of the gene encoding the sodium-dependent multivitamin transporter in JAr choriocarcinoma cells. Eur.J Nutr. 2004;43(1):23-31. View abstract.
    16. Dakshinamurti, K. Biotin--a regulator of gene expression. J Nutr.Biochem. 2005;16(7):419-423. View abstract.
    17. Daniells, S. and Hardy, G. Hair loss in long-term or home parenteral nutrition: are micronutrient deficiencies to blame? Curr.Opin.Clin.Nutr.Metab Care 2010;13(6):690-697. View abstract.
    18. Dashwood, R. H. and Ho, E. Dietary histone deacetylase inhibitors: from cells to mice to man. Semin.Cancer Biol. 2007;17(5):363-369. View abstract.
    19. de Wolf, F. A. and Brett, G. M. Ligand-binding proteins: their potential for application in systems for controlled delivery and uptake of ligands. Pharmacol.Rev. 2000;52(2):207-236. View abstract.
    20. Dreizen, S. Nutrition and the immune response -- a review. Int J Vitam.Nutr.Res. 1979;49(2):220-228. View abstract.
    21. Dror, Y., Stern, F., Berner, Y. N., Kaufmann, N. A., Berry, E., Maaravi, Y., Altman, H., Cohen, A., Leventhal, A., and Kaluski, D. N. [Micronutrient (vitamins and minerals) supplementation for the elderly, suggested by a special committee nominated by Ministry of Health]. Harefuah 2001;140(11):1062-7, 1117. View abstract.
    22. du, Vigneaud, V, Melville, D. B., Folkers, K., Wolf, D. E., Mozingo, D. E., Keresztesy, J. C., and Harris, S. A. The structure of biotin: a study of desthiobiotin. J.Biol.Chem 1942;(146):475-485.
    23. du, Vigneaud, V. THE STRUCTURE OF BIOTIN. Science 11-20-1942;96(2499):455-461. View abstract.
    24. Eakin, R. E., Snell, E. E., and Williams, R. J. Concentrationand assay of avidin, injury-producing agents in raw egg white. J Biol Chem. 1941;(40):535-43.
    25. Esposito, S. Immune system and surgical site infection. J Chemother. 2001;13 Spec No 1(1):12-16. View abstract.
    26. Fernandez-Mejia, C. Pharmacological effects of biotin. J Nutr.Biochem. 2005;16(7):424-427. View abstract.
    27. Furukawa, Y. [Enhancement of glucose-induced insulin secretion and modification of glucose metabolism by biotin]. Nippon Rinsho 1999;57(10):2261-2269. View abstract.
    28. Gralla, M., Camporeale, G., and Zempleni, J. Holocarboxylase synthetase regulates expression of biotin transporters by chromatin remodeling events at the SMVT locus. J Nutr.Biochem. 2008;19(6):400-408. View abstract.
    29. Grammatikopoulou, M. G., Daskalou, E., and Tsigga, M. Diet, feeding practices, and anthropometry of children and adolescents with cerebral palsy and their siblings. Nutrition 2009;25(6):620-626. View abstract.
    30. Hassan, Y. I. and Zempleni, J. Epigenetic regulation of chromatin structure and gene function by biotin. J Nutr. 2006;136(7):1763-1765. View abstract.
    31. Hymes, J. and Wolf, B. Biotinidase and its roles in biotin metabolism. Clin.Chim.Acta 11-15-1996;255(1):1-11. View abstract.
    32. Hymes, J. and Wolf, B. Human biotinidase isn't just for recycling biotin. J Nutr. 1999;129(2S Suppl):485S-489S. View abstract.
    33. Jaffrey, S. R. and Snyder, S. H. The biotin switch method for the detection of S-nitrosylated proteins. Sci STKE. 6-12-2001;2001(86):l1. View abstract.
    34. Kogl, F. and Tonnis, B. Ober das Bios-Problem. Darstellung von krystallisiertem Biotin aus Eigelb. Z.Physiol.Chem 1932;(242):43-73.
    35. Kothapalli, N., Camporeale, G., Kueh, A., Chew, Y. C., Oommen, A. M., Griffin, J. B., and Zempleni, J. Biological functions of biotinylated histones. J Nutr.Biochem. 2005;16(7):446-448. View abstract.
    36. Leon-Del-Rio, A. Biotin-dependent regulation of gene expression in human cells. J Nutr.Biochem. 2005;16(7):432-434. View abstract.
    37. Lesch, H. P., Kaikkonen, M. U., Pikkarainen, J. T., and Yla-Herttuala, S. Avidin-biotin technology in targeted therapy. Expert.Opin.Drug Deliv. 2010;7(5):551-564. View abstract.
    38. Livaniou, E., Costopoulou, D., Vassiliadou, I., Leondiadis, L., Nyalala, J. O., Ithakissios, D. S., and Evangelatos, G. P. Analytical techniques for determining biotin. J Chromatogr.A 6-9-2000;881(1-2):331-343. View abstract.
    39. Magnuson, N. S. and Perryman, L. E. Metabolic defects in severe combined immunodeficiency in man and animals. Comp Biochem.Physiol B 1986;83(4):701-710. View abstract.
    40. Malaguzzi, Valeri C. [Vitamins in metabolic diseases]. Acta Vitaminol.Enzymol. 1981;3(1):43-56. View abstract.
    41. Mall, G. K., Chew, Y. C., and Zempleni, J. Biotin requirements are lower in human Jurkat lymphoid cells but homeostatic mechanisms are similar to those of HepG2 liver cells. J Nutr. 2010;140(6):1086-1092. View abstract.
    42. McMurray, D. N. Cell-mediated immunity in nutritional deficiency. Prog.Food Nutr.Sci 1984;8(3-4):193-228. View abstract.
    43. Michalski, A. J., Berry, G. T., and Segal, S. Holocarboxylase synthetase deficiency: 9-year follow-up of a patient on chronic biotin therapy and a review of the literature. J Inherit.Metab Dis. 1989;12(3):312-316. View abstract.
    44. Miller, S. J. Nutritional deficiency and the skin. J Am.Acad.Dermatol. 1989;21(1):1-30. View abstract.
    45. Mock, D. M. Marginal biotin deficiency is teratogenic in mice and perhaps humans: a review of biotin deficiency during human pregnancy and effects of biotin deficiency on gene expression and enzyme activities in mouse dam and fetus. J Nutr.Biochem. 2005;16(7):435-437. View abstract.
    46. Mock, D. M. Skin manifestations of biotin deficiency. Semin.Dermatol. 1991;10(4):296-302. View abstract.
    47. Narisawa, K. [Molecular basis of vitamin-responsive inborn errors of metabolism]. Nippon Rinsho 1999;57(10):2301-2306. View abstract.
    48. Nikiforova, V., Kempa, S., Zeh, M., Maimann, S., Kreft, O., Casazza, A. P., Riedel, K., Tauberger, E., Hoefgen, R., and Hesse, H. Engineering of cysteine and methionine biosynthesis in potato. Amino.Acids 2002;22(3):259-278. View abstract.
    49. Nyhan, W. L. Inborn errors of biotin metabolism. Arch.Dermatol. 1987;123(12):1696-1698a. View abstract.
    50. Nyhan, W. L. Multiple carboxylase deficiency. Int J Biochem. 1988;20(4):363-370. View abstract.
    51. O'Keefe, S. J., Ou, J., Aufreiter, S., O'Connor, D., Sharma, S., Sepulveda, J., Fukuwatari, T., Shibata, K., and Mawhinney, T. Products of the colonic microbiota mediate the effects of diet on colon cancer risk. J Nutr. 2009;139(11):2044-2048. View abstract.
    52. Ozand, P. T., Gascon, G. G., Al Essa, M., Joshi, S., Al Jishi, E., Bakheet, S., Al Watban, J., Al Kawi, M. Z., and Dabbagh, O. Biotin-responsive basal ganglia disease: a novel entity. Brain 1998;121 ( Pt 7):1267-1279. View abstract.
    53. Pacheco-Alvarez, D., Solorzano-Vargas, R. S., Gravel, R. A., Cervantes-Roldan, R., Velazquez, A., and Leon-Del-Rio, A. Paradoxical regulation of biotin utilization in brain and liver and implications for inherited multiple carboxylase deficiency. J Biol Chem. 12-10-2004;279(50):52312-52318. View abstract.
    54. Petrelli, F., Moretti, P., and Paparelli, M. Intracellular distribution of biotin-14COOH in rat liver. Mol.Biol.Rep. 2-15-1979;4(4):247-252. View abstract.
    55. Petronzelli, F., Pelliccia, A., Anastasi, A. M., Lindstedt, R., Manganello, S., Ferrari, L. E., Albertoni, C., Leoni, B., Rosi, A., D'Alessio, V., Deiana, K., Paganelli, G., and De, Santis R. Therapeutic use of avidin is not hampered by antiavidin antibodies in humans. Cancer Biother.Radiopharm. 2010;25(5):563-570. View abstract.
    56. Pletsityi, K. D. [Vitamins and immunity. Biotin, pantothenic acid and riboflavin]. Vopr.Pitan. 1990;(4):18-22. View abstract.
    57. POTH, E. J. Intestinal antisepsis in surgery. J Am.Med Assoc. 12-26-1953;153(17):1516-1521. View abstract.
    58. Prasad, A. N. and Seshia, S. S. Status epilepticus in pediatric practice: neonate to adolescent. Adv.Neurol. 2006;97:229-243. View abstract.
    59. Prasad, P. D. and Ganapathy, V. Structure and function of mammalian sodium-dependent multivitamin transporter. Curr.Opin.Clin.Nutr.Metab Care 2000;3(4):263-266. View abstract.
    60. Rodriguez, Melendez R. [Importance of biotin metabolism]. Rev.Invest Clin. 2000;52(2):194-199. View abstract.
    61. Rodriguez-Melendez, R. and Zempleni, J. Nitric oxide signaling depends on biotin in Jurkat human lymphoma cells. J Nutr. 2009;139(3):429-433. View abstract.
    62. Rodriguez-Melendez, R. and Zempleni, J. Regulation of gene expression by biotin (review). J Nutr.Biochem. 2003;14(12):680-690. View abstract.
    63. Rodriguez-Melendez, R., Griffin, J. B., Sarath, G., and Zempleni, J. High-Throughput Immunoblotting Identifies Biotin-Dependent Signaling Proteins in HepG2 Hepatocarcinoma Cells. J Nutr. 2005;135(7):1659-1666. View abstract.
    64. Rogovik, A. L., Vohra, S., and Goldman, R. D. Safety considerations and potential interactions of vitamins: should vitamins be considered drugs? Ann.Pharmacother. 2010;44(2):311-324. View abstract.
    65. Roje, S. Vitamin B biosynthesis in plants. Phytochemistry 2007;68(14):1904-1921. View abstract.
    66. Said, H. M. and Mohammed, Z. M. Intestinal absorption of water-soluble vitamins: an update. Curr.Opin.Gastroenterol. 2006;22(2):140-146. View abstract.
    67. Said, H. M. Cellular uptake of biotin: mechanisms and regulation. J Nutr. 1999;129(2S Suppl):490S-493S. View abstract.
    68. Said, H. M. Recent advances in carrier-mediated intestinal absorption of water-soluble vitamins. Annu.Rev.Physiol 2004;66:419-446. View abstract.
    69. Said, H. M., Mock, D. M., and Collins, J. C. Regulation of intestinal biotin transport in the rat: effect of biotin deficiency and supplementation. Am.J Physiol 1989;256(2 Pt 1):G306-G311. View abstract.
    70. Scheinfeld, N., Dahdah, M. J., and Scher, R. Vitamins and minerals: their role in nail health and disease. J Drugs Dermatol. 2007;6(8):782-787. View abstract.
    71. Sedel, F., Lyon-Caen, O., and Saudubray, J. M. [Treatable hereditary neuro-metabolic diseases]. Rev.Neurol.(Paris) 2007;163(10):884-896. View abstract.
    72. Shriver, B. J., Roman-Shriver, C., and Allred, J. B. Depletion and repletion of biotinyl enzymes in liver of biotin-deficient rats: evidence of a biotin storage system. J Nutr. 1993;123(6):1140-1149. View abstract.
    73. Snodgrass, S. R. Vitamin neurotoxicity. Mol.Neurobiol. 1992;6(1):41-73. View abstract.
    74. Spector, R. and Johanson, C. E. Vitamin transport and homeostasis in mammalian brain: focus on Vitamins B and E. J Neurochem. 2007;103(2):425-438. View abstract.
    75. Suzuki, Y., Yang, X., Aoki, Y., Kure, S., and Matsubara, Y. Mutations in the holocarboxylase synthetase gene HLCS. Hum.Mutat. 2005;26(4):285-290. View abstract.
    76. Sweetman, L. and Nyhan, W. L. Inheritable biotin-treatable disorders and associated phenomena. Annu.Rev.Nutr. 1986;6:317-343. View abstract.
    77. Sydenstricker, V. P., Singal, S. A., Briggs, A. P., Devaughn, N. M., and Isbell, H. Observations on the "egg white injury" in man and its cure with biotin concentrate. J Am Med Assn 1942;(8):199-200.
    78. Sydenstricker, V. P., Singal, S. A., Briggs, A. P., Devaughn, N. M., and Isbell, H. PRELIMINARY OBSERVATIONS ON "EGG WHITE INJURY" IN MAN AND ITS CURE WITH A BIOTIN CONCENTRATE. Science 2-13-1942;95(2459):176-177. View abstract.
    79. Tarmina, M. S. Self-selected diet of adult women with families. 1992;257.
    80. Tong, L. Acetyl-coenzyme A carboxylase: crucial metabolic enzyme and attractive target for drug discovery. Cell Mol.Life Sci 2005;62(16):1784-1803. View abstract.
    81. Tsao, C. Y. Current trends in the treatment of infantile spasms. Neuropsychiatr.Dis.Treat. 2009;5:289-299. View abstract.
    82. van der Knaap, M. S., Jakobs, C., and Valk, J. Magnetic resonance imaging in lactic acidosis. J Inherit.Metab Dis. 1996;19(4):535-547. View abstract.
    83. Vilches-Flores, A. and Fernandez-Mejia, C. [Effect of biotin upon gene expression and metabolism]. Rev.Invest Clin. 2005;57(5):716-724. View abstract.
    84. Vlaming, M. L., Lagas, J. S., and Schinkel, A. H. Physiological and pharmacological roles of ABCG2 (BCRP): recent findings in Abcg2 knockout mice. Adv.Drug Deliv.Rev. 1-31-2009;61(1):14-25. View abstract.
    85. Wallace, J. C., Jitrapakdee, S., and Chapman-Smith, A. Pyruvate carboxylase. Int J Biochem.Cell Biol. 1998;30(1):1-5. View abstract.
    86. Wilson, C. J., Myer, M., Darlow, B. A., Stanley, T., Thomson, G., Baumgartner, E. R., Kirby, D. M., and Thorburn, D. R. Severe holocarboxylase synthetase deficiency with incomplete biotin responsiveness resulting in antenatal insult in samoan neonates. J Pediatr. 2005;147(1):115-118. View abstract.
    87. Wolf, B. Clinical issues and frequent questions about biotinidase deficiency. Mol.Genet.Metab 2010;100(1):6-13. View abstract.
    88. Yoshikawa, K. [Vitamin and dermatology]. Nippon Rinsho 1999;57(10):2385-2389. View abstract.
    89. Zempleni, J. and Mock, D. M. Advanced analysis of biotin metabolites in body fluids allows a more accurate measurement of biotin bioavailability and metabolism in humans. J Nutr. 1999;129(2S Suppl):494S-497S. View abstract.
    90. Zempleni, J. and Mock, D. M. Utilization of biotin in proliferating human lymphocytes. J Nutr. 2000;130(2S Suppl):335S-337S. View abstract.
    91. Zempleni, J. Uptake, localization, and noncarboxylase roles of biotin *. Annu.Rev Nutr. 2005;25:175-196. View abstract.
    92. Zempleni, J., Green, G. M., Spannagel, A. W., and Mock, D. M. Biliary excretion of biotin and biotin metabolites is quantitatively minor in rats and pigs. J Nutr. 1997;127(8):1496-1500. View abstract.
    93. Zempleni, J., Hassan, Y. I., and Wijeratne, S. S. Biotin and biotinidase deficiency. Expert.Rev.Endocrinol.Metab 11-1-2008;3(6):715-724. View abstract.
    94. Zempleni, J., McCormick, D. B., and Mock, D. M. Identification of biotin sulfone, bisnorbiotin methyl ketone, and tetranorbiotin-l-sulfoxide in human urine. Am.J Clin.Nutr. 1997;65(2):508-511. View abstract.
    95. Zeng, W. Q., Al Yamani, E., Acierno, J. S., Jr., Slaugenhaupt, S., Gillis, T., MacDonald, M. E., Ozand, P. T., and Gusella, J. F. Biotin-responsive basal ganglia disease maps to 2q36.3 and is due to mutations in SLC19A3. Am.J Hum.Genet. 2005;77(1):16-26. View abstract.
    96. Zlotkin, S. H., Stallings, V. A., and Pencharz, P. B. Total parenteral nutrition in children. Pediatr.Clin.North Am. 1985;32(2):381-400. View abstract.
    97. Albarracin C, Fuqua B, Evans JL, Goldfine ID. Chromium picolinate and biotin combination improves glucose metabolism in treated, uncontrolled overweight to obese patients with type 2 diabetes. Diabetes Metab Res Rev 2008;24:41-51. View abstract.
    98. Baez-Saldana A, Zendejas-Ruiz I, Revilla-Monsalve C, et al. Effects of biotin on pyruvate carboxylase, acetyl-CoA carboxylase, propionyl-CoA carboxylase, and markers for glucose and lipid homeostasis in type 2 diabetic patients and nondiabetic subjects. Am J Clin Nutr 2004;79:238-43. View abstract.
    99. Bonjour JP. Biotin in human nutrition. Ann N Y Acad Sci 1985;447:97-104. View abstract.
    100. Brewster MA, Schedewie H. Trimethylaminuria. Ann Clin Lab Sci 1983;13:20-4. View abstract.
    101. Camacho FM, Garcia-Hernandez MJ. Zinc aspartate, biotin, and clobetasol propionate in the treatment of alopecia areata in childhood. Pediatr Dermatol 1999;16:336-8. View abstract.
    102. Coggeshall JC, Heggers JP, Robson MC, et al. Biotin status and plasma glucose in diabetics. Ann N Y Acad Sci 1985;447:389-92.
    103. Debourdeau PM, Djezzar S, Estival JL, et al. Life-threatening eosinophilic pleuropericardial effusion related to vitamins B5 and H. Ann Pharmacother 2001;35:424-6. View abstract.
    104. Eakin RE, Snell EE, and Williams RJ. Concentrationand assay of avidin, injury-producing agents in raw egg white. J Biol Chem. 1941;(40):535-43.
    105. Ebek, Inc. issues voluntary nationwide recall of Liviro3, a product marketed as a dietary supplement. Ebek Press Release, January 19, 2007. Available at: http://www.fda.gov/oc/po/firmrecalls/ebek01_07.html.
    106. Fiume MZ. Cosmetic Ingredient Review Expert Panel. Final report on the safety assessment of biotin. Int J Toxicol. 2001;20 Suppl 4:1-12. View abstract.
    107. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://books.nap.edu/books/0309065542/html/.
    108. Geohas J, Daly A, Juturu V, et al. Chromium picolinate and biotin combination reduces atherogenic index of plasma in patients with type 2 diabetes mellitus: a placebo-controlled, double-blinded, randomized clinical trial. Am J Med Sci. 2007 Mar;333:145-53. View abstract.
    109. Geohas J, Finch M, Juturu V, et al. Improvement in Fasting Blood Glucose with the Combination of Chromium Picolinate and Biotin in Type 2 Diabetes Mellitus. American Diabetes Association 64th Annual Meeting, June 2004, Orlando, Florida, abstract 191-OR.
    110. Green NM. Avidin. 1. The use of (14-C)biotin for kinetic studies and for assay. Biochem. J. 1963;89:585-591. View abstract.
    111. Grundy WE, Freed M, Johnson H.C., et al. The effect of phthalylsulfathiazole (sulfathalidine) on the excretion of B-vitamins by normal adults. Arch Biochem. 1947 Nov;15:187-94. View abstract.
    112. Henry JG, Sobki S, Afafat N. Interference by biotin therapy on measurement of TSH and FT4 by enzyme immunoassay on Boehringer Mannheim ES 700 analyzer. Ann Clin Biochem 1996;33:162-3. View abstract.
    113. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. View abstract.
    114. Hochman LG, Scher RK, Meyerson MS. Brittle nails: response to daily biotin supplementation. Cutis 1993;51:303-5. View abstract.
    115. Keipert JA. Oral use of biotin in seborrhoeic dermatitis of infancy: a controlled trial. Med J Aust 1976;1:584-5. View abstract.
    116. Koutsikos D, Agroyannis B, Tzanatos-Exarchou H. Biotin for diabetic peripheral neuropathy. Biomed Pharmacother 1990;44:511-4. View abstract.
    117. Krause KH, Berlit P, Bonjour JP. Vitamin status in patients on chronic anticonvulsant therapy. Int J Vitam Nutr Res 1982;52:375-85. View abstract.
    118. Krause KH, Bonjour JP, Berlit P, Kochen W. Biotin status of epileptics. Ann N Y Acad Sci 1985;447:297-313. View abstract.
    119. Krause KH, Kochen W, Berlit P, Bonjour JP. Excretion of organic acids associated with biotin deficiency in chronic anticonvulsant therapy. Int J Vitam Nutr Res 1984;54:217-22. View abstract.
    120. Lininger SW. The Natural Pharmacy. 1st ed. Rocklin, CA: Prima Publishing; 1998.
    121. Mock DM, Dyken ME. Biotin catabolism is accelerated in adults receiving long-term therapy with anticonvulsants. Neurology 1997;49:1444-7. View abstract.
    122. Mock DM, Dyken ME. Biotin deficiency results from long-term therapy with anticonvulsants (abstract). Gastroenterology 1995;108:A740.
    123. Mock DM, Mock NI, Nelson RP, Lombard KA. Disturbances in biotin metabolism in children undergoing long-term anticonvulsant therapy. J Pediatr Gastroentereol Nutr 1998;26:245-50. View abstract.
    124. Mock DM, Quirk JG, Mock NI. Marginal biotin deficiency during normal pregnancy. Am J Clin Nutr 2002;75:295-9. View abstract.
    125. Mock NI, Malik MI, Stumbo PJ, et al. Increased urinary excretion of 3-hydroxyisovaleric acid and decreased urinary excretion of biotin are sensitive early indicators of decreased status in experimental biotin deficiency. Am J Clin Nutr 1997;65:951-8. View abstract.
    126. Rathman SC, Eisenschenk S, McMahon RJ. The abundance and function of biotin-dependent enzymes are reduced in rats chronically administered carbamazepine. J Nutr 2002;132:3405-10. View abstract.
    127. Rivera JA, González-Cossío T, Flores M, et al. Multiple micronutrient supplementation increases the growth of Mexican infants. Am J Clin Nutr. 2001 Nov;74:657-63. View abstract.
    128. Rodriguez-Melendez R, Griffin JB, Zempleni J. Biotin supplementation increases expression of the cytochrome P450 1B1 gene in Jurkat cells, increasing the occurrence of single-stranded DNA breaks. J Nutr. 2004 Sep;134:2222-8. View abstract.
    129. Roth K.S. Biotin in clinical medicine--a review. Am J Clin Nutr. 1981 Sep;34:1967-74. View abstract.
    130. Said HM, Redha R, Nylander W. Biotin transport in the human intestine: inhibition by anticonvulsant drugs. Am J Clin Nutr 1989;49:127-31. View abstract.
    131. Said HM. Biotin: the forgotten vitamin. Am J Clin Nutr. 2002;75:179-80. View abstract.
    132. Schulpis KH, Georgala S, Papakonstantinou ED, et al. The effect of isotretinoin on biotinidase activity. Skin Pharmacol Appl Skin Physiol. 1999 Jan-Apr;12:28-33. View abstract.
    133. Sealey WM, Teague AM, Stratton SL, Mock DM. Smoking accelerates biotin catabolism in women. Am J Clin Nutr 2004;80:932-5. View abstract.
    134. Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999.
    135. Singer GM, Geohas J. The effect of chromium picolinate and biotin supplementation on glycemic control in poorly controlled patients with type 2 diabetes mellitus: a placebo-controlled, double-blinded, randomized trial. Diabetes Technol Ther 2006;8:636-43. View abstract.
    136. Spencer RP and Brody KR. Biotin transport by small intestine of rat, hamster, and other species. Am J Physiol. 1964 Mar;206:653-7. View abstract.
    137. Zempleni J, Helm RM, Mock DM. In vivo biotin supplementation at a pharmacologic dose decreases proliferation rates of human peripheral blood mononuclear cells and cytokine release. J Nutr 2001;131:1479-84. View abstract.
    138. Zempleni J, Mock DM. Bioavailability of biotin given orally to humans in pharmacologic doses. Am J Clin Nutr 1999;69:504-8. View abstract.
    139. Zempleni J, Mock DM. Biotin biochemistry and human requirements. J Nutr Biochem. 1999 Mar;10:128-38. View abstract.
    140. Zempleni J, Wijeratne SS, Hassan YI. Biotin. Biofactors. 2009 Jan-Feb;35:36-46. View abstract.

     

    Als Nahrungsergänzungsmittel nimm täglich zwei Tabletten ein.


    Nur registrierte Benutzer kann Bewertung.

    60 tablets
    Supplement Facts
    Serving Size2tablets()
    Servings Per Container30
    Amount Per Serving
    Calories
    Calories From Fat
    % Daily Value*
    Vitamin A (as retinyl acetate)3000µg375%
    Vitamin C (as ascorbic acid)500mg625%
    Vitamin D (as cholecalciferol)10µgmg5%
    Vitamin E (as DL-alpha-tocopheryl acetate)100mg833%
    Thiamin (as thiamin monoitrate)75mg6818%
    Riboflavin40mg2857%
    Niacin (as niacinamide)75mg468%
    Vitamin B6 (as Pyridoxine HCl)25mg1785%
    Folic Acid400µg200%
    Vitamin B12 (as cyanocobalamin)250µg10000%
    Biotin75µg150%
    Pantothenic Acid ( as-dcalcium pantothenate)100mg1666%
    Iron (as iron fumarate)17mg121%
    Selenium (sodium selenite)50µg62%
    Copper (as copper sulphate)2mg200%
    Chromium (as chromium chloride)25µg62%
    CitrusBioflavonids (from citrus aurantium)100mg**
    Bee pollen50mg**
    Panax ginseng root extract50mg**
    Guarana seed extract (Paullinia cupana)25mg**
    Valerian root powder (Valeriana officinalis)25mg**
    Licorice root powder (Glycyrrhiza glabra)25mg**
    *RDA - Recommended Dietary Allowance
    ***No RDA has been established
    Ingredients
    Füllstoffe (mikrokristalline Cellulose, Hydroxypropylmethylcellulose), L-Ascorbinsäure, DL-α-Tocopherylacetat, Calcium-D-Pantothenat, Citrus aurantium Extrakt, Thiaminmononitrat, Überzugsmittel [Stabilisator (Hydroxypropylmethylcellulose), Farbstoffe (Eisenoxide), Nicotinamid, Trennmittel (Magnesiumsalze von Fettsäuren), Eisenfumarat Bienenpollen, Panax ginseng Wurzelextrakt, Guaranasamen Extrakt, Riboflavin, Pyridoxinhydrochlorid, Baldrianwurzel Pulver, Süßholzwurzel Pulver, Kupfersulfat, Cholecalciferol, Retinylacetat, Folsäure, Cyanocobalamin, Chrom-III-Chlorid, Natrium-Selenit, Biotin.


    Kunden, die dieses Produkt gekauft haben, kauften auch ...